DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012 imex curation Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250696X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012 imex curation Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250694X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012 imex curation Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250692X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012 imex curation Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250691X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012 imex curation Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250695X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012 imex curation Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250693X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012 imex curation Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. Only protein-protein interactions in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Barber MF., Michishita-Kioi E., Xi Y., Tasselli L., Kioi M., Moqtaderi Z., Tennen RI., Paredes S., Young NL., Chen K., Struhl K., Garcia BA., Gozani O., Li W., Chua KF. DIP original experiment: DIP-250697X Nature 2012 IMEx SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. elk4_human ETS domain-containing protein Elk-4 ELK4 SAP1 Serum response factor accessory protein 1 protein protein human Homo sapiens Human MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQTPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPSTPGPFSPDLQKT DIP protein P28324 original sequence version: 153 DIP protein P28324 original sequence version: 121 80EE3E69995C7A7D sir7_human NAD-dependent protein deacetylase sirtuin-7 NAD-dependent protein deacylase sirtuin-7 SIR2-like protein 7 SIRT7 SIR2L7 Regulatory protein SIR2 homolog 7 protein protein human Homo sapiens Human MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRGCTKRTKRKKVT DIP protein Q9NRC8 original sequence version: 127 DIP protein Q9NRC8 original sequence version: 101 55D7736A864AFE6F h3k9ac H3K9Ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ARTKQTARKSTGGKAPRKQLAK sir1_human NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacylase sirtuin-1 SIRT1 SIR2L1 SIR2-like protein 1 Regulatory protein SIR2 homolog 1 protein protein human Homo sapiens Human MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS DIP protein Q96EB6 original sequence version: 140 DIP protein Q96EB6 original sequence version: 71 DIP protein Q96EB6 original sequence version: 125 DIP protein Q96EB6 original sequence version: 115 DIP protein Q96EB6 original sequence version: 63 DIP protein Q96EB6-1 original sequence version: 102 DIP protein Q96EB6 original sequence version: 102 DIP protein Q96EB6 original sequence version: 98 DIP protein Q96EB6 original sequence version: 144 DIP protein Q96EB6 original sequence version: 120 DIP protein Q96EB6-1 original sequence version: 120 DIP protein Q96EB6 original sequence version: 113 DIP protein Q96EB6-1 original sequence version: 117 2D3BEA6D73DA229F h4-2 Histone 4 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) SGRGKGGKGLGKGGAKRHRKVLR h2b-2 Histone 2B peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) PEPAKSAPAPKKGSKKAVTKAQK elk4-sirt7-1 4 8 unspecified role unspecified role bait bait human Homo sapiens Human 9 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association h2b-sirt1-1 1 13 enzyme target enzyme target substrate substrate unspecified role unspecified role K12Ac K12Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain K15Ac K15Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain K20Ac K20Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain in vitro In vitro 11 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper deacetylation deacetylation reaction deacetylation h3-sirt7-1 2 10 enzyme target enzyme target substrate substrate unspecified role unspecified role K18Ac K18Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain in vitro In vitro 9 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper deacetylation deacetylation reaction deacetylation elk4-sirt7-2 3 8 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 9 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association h4-sirt1-1 7 12 enzyme target enzyme target substrate substrate unspecified role unspecified role K5Ac K5Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain K8Ac K8Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain K12Ac K12Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain in vitro In vitro 11 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper deacetylation deacetylation reaction deacetylation h3-sirt1-1 5 11 enzyme enzyme unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper 10 enzyme target enzyme target substrate substrate unspecified role unspecified role K18Ac K18Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain K9Ac K9Ac naclys N-acetylated L-lysine NAcLys certain certain sequence position certain certain certain sequence position certain in vitro In vitro deacetylation deacetylation reaction deacetylation sirt7-elk4-1 6 8 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 9 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association