DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. DIP original experiment: DIP-251636X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. DIP original experiment: DIP-251638X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. DIP original experiment: DIP-251635X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. DIP original experiment: DIP-251637X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Bezerra GA., Dobrovetsky E., Viertlmayr R., Dong A., Binter A., Abramic M., Macheroux P., Dhe-Paganon S., Gruber K. DIP original experiment: DIP-251634X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III. ivypw IVYPW peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) IVYPW q9ny33-1 Dipeptidyl peptidase 3 DPP3 Dipeptidyl aminopeptidase III Dipeptidyl arylamidase III Dipeptidyl peptidase III Enkephalinase B protein protein human Homo sapiens Human MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADARFWKGPSEAPSGQA DIP protein Q9NY33-1 original sequence version: 126 endomorphin1 Opioid peptide endomorphin-1 peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) YPWF tynorphin Opioid peptide tynorphin peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) VVYPW leuenkephalin Opioid peptide Leu-enkephalin peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) YGGFL dpp3-endomorphin1-1 1 8 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role Region 1-726 Region 1-726 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9NY33-1:p.Glu451Ala E451A mutation mutation certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E451A'. Wed May 02 19:15:59 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu451ala' Tue Jun 30 19:43:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu451Ala' ecolx Escherichia coli direct interaction direct interaction dpp3-tynorphin-1 5 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role Region 1-726 Region 1-726 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9NY33-1:p.Glu451Ala E451A mutation mutation certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E451A'. Wed May 02 15:33:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu451ala' Tue Jun 30 16:45:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu451Ala' ecolx Escherichia coli direct interaction direct interaction dpp3-ivypw-1 2 6 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role Region 1-726 Region 1-726 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9NY33-1:p.Glu451Ala E451A mutation mutation certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E451A'. Wed May 02 15:41:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu451ala' Tue Jun 30 17:07:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu451Ala' ecolx Escherichia coli direct interaction direct interaction dpp3-leuenkephalin-1 4 10 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role Region 1-726 Region 1-726 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9NY33-1:p.Glu451Ala E451A mutation mutation certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E451A'. Wed May 02 19:35:52 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu451ala' Tue Jun 30 17:20:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu451Ala' ecolx Escherichia coli direct interaction direct interaction dpp3-tynorphin-2 3 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role Region 1-726 Region 1-726 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9NY33-1:p.Glu451Ala E451A mutation mutation certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E451A'. Wed May 02 18:44:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu451ala' Tue Jun 30 15:59:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu451Ala' ecolx Escherichia coli direct interaction direct interaction