DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (New York, N.Y.) 2012 imex curation McIlwain DR., Lang PA., Maretzky T., Hamada K., Ohishi K., Maney SK., Berger T., Murthy A., Duncan G., Xu HC., Lang KS., Häussinger D., Wakeham A., Itie-Youten A., Khokha R., Ohashi PS., Blobel CP., Mak TW. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot McIlwain DR., Lang PA., Maretzky T., Hamada K., Ohishi K., Maney SK., Berger T., Murthy A., Duncan G., Xu HC., Lang KS., Häussinger D., Wakeham A., Itie-Youten A., Khokha R., Ohashi PS., Blobel CP., Mak TW. DIP original experiment: DIP-268294X Science (New York, N.Y.) 2012 IMEx iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (New York, N.Y.) 2012 imex curation McIlwain DR., Lang PA., Maretzky T., Hamada K., Ohishi K., Maney SK., Berger T., Murthy A., Duncan G., Xu HC., Lang KS., Häussinger D., Wakeham A., Itie-Youten A., Khokha R., Ohashi PS., Blobel CP., Mak TW. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot McIlwain DR., Lang PA., Maretzky T., Hamada K., Ohishi K., Maney SK., Berger T., Murthy A., Duncan G., Xu HC., Lang KS., Häussinger D., Wakeham A., Itie-Youten A., Khokha R., Ohashi PS., Blobel CP., Mak TW. DIP original experiment: DIP-268295X Science (New York, N.Y.) 2012 IMEx iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. ada17_mouse Disintegrin and metalloproteinase domain-containing protein 17 Adam17 Tace TNF-alpha-converting enzyme TNF-alpha convertase protein protein mouse Mus musculus Mouse MRRRLLILTTLVPFVLAPRPPEEAGSGSHPRLEKLDSLLSDYDILSLANIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQNFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNVEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPTVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACVDTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVPAAPKLDHQRMDTIQEDPSTDSHADDDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC DIP protein Q9Z0F8 original sequence version: 157 Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway mint homomint 6B434F80878197F5 rhdf2_mouse Inactive rhomboid protein 2 Rhor Rhomboid veinlet-like protein 6 Rhomboid-related protein Rhbdf2 Rhbdl6 Irhom2 Rhomboid family member 2 protein protein mouse Mus musculus Mouse MASADKNGSNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDSMLPERRKNPAYLKSVSLQEPRGRWQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGDWEGKRQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLPRRKRISVAHMSFQAAAALLKGRSVLDATGQRCRHVKRSFAYPSFLEEDAVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGVPHSASPVSPDGVHIPLKEYSGGRALGPGTQRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQIEQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTGPSDKSDLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNHTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWPWIEYLTCFPFTSRFCEKYELDQVLH DIP protein Q80WQ6 original sequence version: 89 650052E5A4BD9CA5 rhbdf2-adam17-5 1 3 unspecified role unspecified role prey prey mouse Mus musculus Mouse 4 unspecified role unspecified role bait bait T7-tag T7-tag t7 tag t7 tag MASMTGGQQMG epitope tag MASMTGGQQMG epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range mouse Mus musculus Mouse physical association physical association adam17-rhbdf2-3 2 3 unspecified role unspecified role bait bait mouse Mus musculus Mouse 4 unspecified role unspecified role prey prey T7-tag T7-tag t7 tag t7 tag MASMTGGQQMG epitope tag MASMTGGQQMG epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range mouse Mus musculus Mouse physical association physical association