DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature 2011 imex curation Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster pull down pull down predetermined predetermined participant predetermined Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. DIP original experiment: DIP-249520X Nature 2011 IMEx Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature 2011 imex curation Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster pull down pull down anti tag western anti tag western blot anti tag western Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. DIP original experiment: DIP-249519X Nature 2011 IMEx Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature 2011 imex curation Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster pull down pull down predetermined predetermined participant predetermined Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. DIP original experiment: DIP-249518X Nature 2011 IMEx Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature 2011 imex curation Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster pull down pull down predetermined predetermined participant predetermined Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. DIP original experiment: DIP-249516X Nature 2011 IMEx Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature 2011 imex curation Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster pull down pull down predetermined predetermined participant predetermined Kim C., Schmidt T., Cho EG., Ye F., Ulmer TS., Ginsberg MH. DIP original experiment: DIP-249517X Nature 2011 IMEx Basic amino-acid side chains regulate transmembrane integrin signalling. itb3_human Integrin beta-3 Platelet membrane glycoprotein IIIa ITGB3 GP3A protein protein human Homo sapiens Human MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT DIP protein P05106 original sequence version: 202 DIP protein P05106-1 original sequence version: 158 DIP protein P05106-1 original sequence version: 164 DIP protein P05106 original sequence version: 200 DIP protein P05106-1 original sequence version: 213 DIP protein P05106-1 original sequence version: 175 DIP protein P05106-1 original sequence version: 192 DIP protein P05106-1 original sequence version: 171 F246623608E05F9E ita5_human Integrin alpha-5 ITGA5 FNRA Fibronectin receptor subunit alpha Integrin alpha-F VLA-5 CD49 antigen-like family member E protein protein human Homo sapiens Human MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIGFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRSLPYGTAMEKAQLKPPATSDA DIP protein P08648 original sequence version: 123 DIP protein P08648 original sequence version: 137 6B4D558D4F739CBA p08514-1 Integrin alpha-IIb ITGA2B GP2B ITGAB GPalpha IIb Platelet membrane glycoprotein IIb protein protein human Homo sapiens Human MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE DIP protein P08514-1 original sequence version: 146 DIP protein P08514-1 original sequence version: 195 DIP protein P08514-1 original sequence version: 158 itb1_human Integrin beta-1 Fibronectin receptor subunit beta VLA-4 subunit beta ITGB1 FNRB MDF2 MSK12 Glycoprotein IIa protein protein human Homo sapiens Human MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK DIP protein P05556 original sequence version: 139 DIP protein P05556-1 original sequence version: 143 DIP protein P05556 original sequence version: 154 DIP protein P05556 original sequence version: 167 DE35979C1625578C itav_human Integrin alpha-V ITGAV VNRA Vitronectin receptor subunit alpha MSK8 Vitronectin receptor VTNR protein protein human Homo sapiens Human MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET DIP protein P06756 original sequence version: 136 DIP protein P06756 original sequence version: 145 DIP protein P06756 original sequence version: 174 DIP protein P06756-1 original sequence version: 182 DIP protein P06756 original sequence version: 149 364EE25C5303A2D7 itga2b-itgb3-14 4 8 unspecified role unspecified role bait bait Region 985-1039 Region 985-1039 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain TAP-tag TAP-tag tandem tag tandem tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 6 unspecified role unspecified role prey prey Region 707-788 Region 707-788 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Tac-tag Tac-tag fusion protein fusion protein n-term range n-terminal range n-term range n-term range n-terminal range n-term range P05106:p.Lys742Glu K742E/A/S/C/L mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K E Wed May 02 14:52:17 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys742glu' Tue Jun 30 20:20:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys742Glu' P05106:p.Lys742Ala mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain K A Wed May 02 14:40:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys742ala' Tue Jun 30 20:22:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys742Ala' P05106:p.Lys742Ser mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain K S Wed May 02 14:41:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys742ser' Tue Jun 30 16:19:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys742Ser' P05106:p.Lys742Cys mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain K C Wed May 02 17:15:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys742cys' Tue Jun 30 17:02:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys742Cys' P05106:p.Lys742Leu mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain K L Wed May 02 16:39:06 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys742leu' Tue Jun 30 19:09:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys742Leu' crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association itgav-itgb1-1 2 9 unspecified role unspecified role prey prey Region 729-798 Region 729-798 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P05556:p.Lys752Glu K752E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K752E'. Wed May 02 15:02:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys752glu' Tue Jun 30 17:15:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys752Glu' Tac-tag Tac-tag fusion protein fusion protein n-term range n-terminal range n-term range n-term range n-terminal range n-term range crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 10 unspecified role unspecified role bait bait Region 993-1048 Region 993-1048 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain TAP-tag TAP-tag tandem tag tandem tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association itgav-itgb3-11 3 10 unspecified role unspecified role bait bait Region 993-1048 Region 993-1048 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain TAP-tag TAP-tag tandem tag tandem tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 6 unspecified role unspecified role prey prey Region 707-788 Region 707-788 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Tac-tag Tac-tag fusion protein fusion protein n-term range n-terminal range n-term range n-term range n-terminal range n-term range P05106:p.Lys742Glu K742E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K742E'. Wed May 02 18:38:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys742glu' Tue Jun 30 16:48:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys742Glu' crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association itgb3-itgb3-5 5 6 unspecified role unspecified role bait bait Region 707-788 Region 707-788 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain TAP-tag TAP-tag tandem tag tandem tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 6 unspecified role unspecified role prey prey Region 707-788 Region 707-788 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Tac-tag Tac-tag fusion protein fusion protein n-term range n-terminal range n-term range n-term range n-terminal range n-term range crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association itga5-itgb1-4 1 7 unspecified role unspecified role bait bait Region 996-1049 Region 996-1049 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain TAP-tag TAP-tag tandem tag tandem tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 9 unspecified role unspecified role prey prey Region 729-798 Region 729-798 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P05556:p.Lys752Glu K752E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K752E'. Wed May 02 17:16:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys752glu' Tue Jun 30 18:06:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys752Glu' Tac-tag Tac-tag fusion protein fusion protein n-term range n-terminal range n-term range n-term range n-terminal range n-term range crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association