DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro pull down pull down weight by staining molecular weight estimation by staining weight by staining Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220421X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220415X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220419X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220420X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220416X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220412X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220418X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro gdp_gtp exchange gdp/gtp exchange assay gtp/gdp exchange guanine nucleotide exchange assay gtp/gdp exchange guanine nucleotide exchange assay gdp_gtp exchange predetermined predetermined participant predetermined Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220417X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220413X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro pull down pull down weight by staining molecular weight estimation by staining weight by staining Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220422X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro ion exchange chrom ion exchange chromatography IEC IEC ion exchange chrom predetermined predetermined participant predetermined Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220414X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature structural & molecular biology 2011 imex curation Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Mace PD., Wallez Y., Dobaczewska MK., Lee JJ., Robinson H., Pasquale EB., Riedl SJ. DIP original experiment: DIP-220411X Nature structural & molecular biology 2011 IMEx NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. bcar1_human Breast cancer anti-estrogen resistance protein 1 CRK-associated substrate p130cas BCAR1 CAS CRKAS CASS1 Cas scaffolding protein family member 1 protein protein human Homo sapiens Human MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTPSKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVKELGHSTQQFRRVLGQLAAA DIP protein P56945 original sequence version: 113 DIP protein P56945 original sequence version: 116 B81EC3430049E795 rpgf1_human Rap guanine nucleotide exchange factor 1 Guanine nucleotide-releasing factor 2 Protein C3G CRK SH3-binding GNRP RAPGEF1 GRF2 protein protein human Homo sapiens Human MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT DIP protein Q13905 original sequence version: 63 DIP protein Q13905-1 original sequence version: 106 E700631A0EE76CA1 q8n5h7-2 SH2 domain-containing protein 3C SH2D3C NSP3 Novel SH2-containing protein 3 SH2 domain-containing Eph receptor-binding protein 1 UNQ272/PRO309/PRO34088 Cas/HEF1-associated signal transducer protein protein human Homo sapiens Human MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL DIP protein Q8N5H7-2 original sequence version: 82 rap1a_human Ras-related protein Rap-1A GTP-binding protein smg p21A Ras-related protein Krev-1 C21KG G-22K RAP1A KREV1 protein protein human Homo sapiens Human MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL DIP protein P62834 original sequence version: 37 DIP protein P62834 original sequence version: 93 42C39290C98E0A92 o75815-1 Breast cancer anti-estrogen resistance protein 3 BCAR3 NSP2 SH2D3B UNQ271/PRO308 SH2 domain-containing protein 3B Novel SH2-containing protein 2 protein protein human Homo sapiens Human MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL DIP protein O75815-1 original sequence version: 92 bcar1-sh2d3c-1 9 13 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 382-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bcar1-sh2d3c-2 12 13 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 382-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sh2d3c-bcar1-1 1 13 unspecified role unspecified role prey prey C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role bait bait Q8N5H7-2:p.Leu623Glu L623E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L E This feature has been corrected as a result of our quality control procedures. The original label was 'L623E'. Wed May 02 14:55:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu623glu' Tue Jun 30 18:33:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu623Glu' Q8N5H7-2:p.Leu469Arg L469R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L R This feature has been corrected as a result of our quality control procedures. The original label was 'L469R'. Wed May 02 16:00:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu469arg' Tue Jun 30 18:59:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu469Arg' C-terminal domain Region 382-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q8N5H7-2:p.Arg627Glu R627E mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R E This feature has been corrected as a result of our quality control procedures. The original label was 'R627E'. Wed May 02 18:38:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg627glu' Tue Jun 30 17:15:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg627Glu' His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli direct interaction direct interaction rap1a-rapgef1-1 8 16 unspecified role unspecified role unspecified role unspecified role Region 1-167 Region 1-167 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 14 unspecified role unspecified role unspecified role unspecified role Region 830-1077 Region 830-1077 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bcar1-bcar3-1 2 17 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 502-825 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 13 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sh2d3c-bcar1-2 3 13 unspecified role unspecified role prey prey eGFP-tag eGFP-tag egfp tag enhanced green fluorescent protein tag enhanced green fluorescent protein EGFP enhanced green fluorescent protein EGFP egfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P56945:p.Leu787Glu L787E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L E This feature has been corrected as a result of our quality control procedures. The original label was 'L787E'. Wed May 02 19:02:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu787glu' Tue Jun 30 19:47:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu787Glu' P56945:p.Phe794Arg F794R mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F R This feature has been corrected as a result of our quality control procedures. The original label was 'F794R'. Wed May 02 19:21:38 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe794arg' Tue Jun 30 16:17:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe794Arg' chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey 15 unspecified role unspecified role bait bait chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey physical association physical association bcar1-sh2d3c-3 10 13 unspecified role unspecified role bait bait C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P56945:p.[Leu787Glu;Phe794Arg] L787E/F794R mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F R certain certain sequence position certain certain certain sequence position certain L E This feature has been corrected as a result of our quality control procedures. The original label was 'L787E/F794R'. Wed May 02 17:58:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu787glu,phe794arg' Tue Jun 30 20:06:48 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Leu787Glu;Phe794Arg]' P56945:p.[Phe794Glu;Asp797Arg] F794E/D797R mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D R certain certain sequence position certain certain certain sequence position certain F E This feature has been corrected as a result of our quality control procedures. The original label was 'F794E/D797R'. Wed May 02 16:22:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe794glu,asp797arg' Tue Jun 30 19:23:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Phe794Glu;Asp797Arg]' P56945:p.Leu787Glu L787E mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L E This feature has been corrected as a result of our quality control procedures. The original label was 'L787E'. Wed May 02 17:34:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu787glu' Tue Jun 30 19:46:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu787Glu' P56945:p.Phe794Arg F794R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F R This feature has been corrected as a result of our quality control procedures. The original label was 'F794R'. Wed May 02 16:31:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe794arg' Tue Jun 30 19:00:00 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe794Arg' P56945:p.Asp797Arg D797R mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D R This feature has been corrected as a result of our quality control procedures. The original label was 'D797R'. Wed May 02 17:02:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp797arg' Tue Jun 30 19:20:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp797Arg' ecolx Escherichia coli 15 unspecified role unspecified role prey prey C-terminal domain Region 382-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bcar1-sh2d3c-4 11 13 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 382-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bcar1-sh2d3c-5 6 13 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 15 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 382-703 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction sh2d3c-bcar1-3 7 13 unspecified role unspecified role prey prey eGFP-tag eGFP-tag egfp tag enhanced green fluorescent protein tag enhanced green fluorescent protein EGFP enhanced green fluorescent protein EGFP egfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey 15 unspecified role unspecified role bait bait Q8N5H7-2:p.Leu623Glu L623E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L E This feature has been corrected as a result of our quality control procedures. The original label was 'L623E'. Wed May 02 15:25:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu623glu' Tue Jun 30 19:25:57 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu623Glu' Q8N5H7-2:p.Leu469Arg L469R mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L R This feature has been corrected as a result of our quality control procedures. The original label was 'L469R'. Wed May 02 20:02:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu469arg' Tue Jun 30 18:54:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu469Arg' chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey physical association physical association bcar1-bcar3-2 5 17 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 502-825 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 13 unspecified role unspecified role unspecified role unspecified role C-terminal domain Region 645-870 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bcar3-bcar1-1 4 17 unspecified role unspecified role bait bait O75815-1:p.Leu744Glu L744E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L E This feature has been corrected as a result of our quality control procedures. The original label was 'L744E'. Wed May 02 16:47:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu744glu' Tue Jun 30 18:57:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu744Glu' O75815-1:p.Arg748Glu R748E mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R E This feature has been corrected as a result of our quality control procedures. The original label was 'R748E'. Wed May 02 16:11:44 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg748glu' Tue Jun 30 19:33:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg748Glu' chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey 13 unspecified role unspecified role prey prey eGFP-tag eGFP-tag egfp tag enhanced green fluorescent protein tag enhanced green fluorescent protein EGFP enhanced green fluorescent protein EGFP egfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey physical association physical association