DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. European journal of human genetics : EJHG 2012 imex curation Braunholz D., Hullings M., Gil-Rodríguez MC., Fincher CT., Mallozzi MB., Loy E., Albrecht M., Kaur M., Limon J., Rampuria A., Clark D., Kline A., Dalski A., Eckhold J., Tzschach A., Hennekam R., Gillessen-Kaesbach G., Wierzba J., Krantz ID., Deardorff MA., Kaiser FJ. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Braunholz D., Hullings M., Gil-Rodríguez MC., Fincher CT., Mallozzi MB., Loy E., Albrecht M., Kaur M., Limon J., Rampuria A., Clark D., Kline A., Dalski A., Eckhold J., Tzschach A., Hennekam R., Gillessen-Kaesbach G., Wierzba J., Krantz ID., Deardorff MA., Kaiser FJ. DIP original experiment: DIP-266613X European journal of human genetics : EJHG 2012 IMEx Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. European journal of human genetics : EJHG 2012 imex curation Braunholz D., Hullings M., Gil-Rodríguez MC., Fincher CT., Mallozzi MB., Loy E., Albrecht M., Kaur M., Limon J., Rampuria A., Clark D., Kline A., Dalski A., Eckhold J., Tzschach A., Hennekam R., Gillessen-Kaesbach G., Wierzba J., Krantz ID., Deardorff MA., Kaiser FJ. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Braunholz D., Hullings M., Gil-Rodríguez MC., Fincher CT., Mallozzi MB., Loy E., Albrecht M., Kaur M., Limon J., Rampuria A., Clark D., Kline A., Dalski A., Eckhold J., Tzschach A., Hennekam R., Gillessen-Kaesbach G., Wierzba J., Krantz ID., Deardorff MA., Kaiser FJ. DIP original experiment: DIP-266612X European journal of human genetics : EJHG 2012 IMEx Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. European journal of human genetics : EJHG 2012 imex curation Braunholz D., Hullings M., Gil-Rodríguez MC., Fincher CT., Mallozzi MB., Loy E., Albrecht M., Kaur M., Limon J., Rampuria A., Clark D., Kline A., Dalski A., Eckhold J., Tzschach A., Hennekam R., Gillessen-Kaesbach G., Wierzba J., Krantz ID., Deardorff MA., Kaiser FJ. Only protein-protein interactions human Homo sapiens Human 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Braunholz D., Hullings M., Gil-Rodríguez MC., Fincher CT., Mallozzi MB., Loy E., Albrecht M., Kaur M., Limon J., Rampuria A., Clark D., Kline A., Dalski A., Eckhold J., Tzschach A., Hennekam R., Gillessen-Kaesbach G., Wierzba J., Krantz ID., Deardorff MA., Kaiser FJ. DIP original experiment: DIP-266614X European journal of human genetics : EJHG 2012 IMEx Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction. scc4_human MAU2 chromatid cohesion factor homolog MAU2 KIAA0892 SCC4 Cohesin loading complex subunit SCC4 homolog protein protein human Homo sapiens Human MAAQAAAAAQAAAAQAAQAEAADSWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL DIP protein Q9Y6X3 original sequence version: 1(def) DIP protein Q9Y6X3 original sequence version: 26 DIP protein Q9Y6X3-1 original sequence version: 108 47E33F5CE6504047 nipbl_human Nipped-B-like protein Delangin SCC2 homolog NIPBL IDN3 SCC2 protein protein human Homo sapiens Human MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKDGTSS DIP protein Q6KC79 original sequence version: 33 DIP protein Q6KC79-1 original sequence version: 132 C275425DF53058A3 nipbl-mau2-2 3 4 unspecified role unspecified role prey prey human Homo sapiens Human 5 unspecified role unspecified role bait bait Region 1-300 Region 1-300 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q6KC79:p.Gly15Arg G15R mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain G R This feature has been corrected as a result of our quality control procedures. The original label was 'G15R'. Wed May 02 15:51:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly15arg' Tue Jun 30 20:09:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly15Arg' Q6KC79:p.Pro29Gln P29Q mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain P Q This feature has been corrected as a result of our quality control procedures. The original label was 'P29Q'. Wed May 02 15:15:47 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro29gln' Tue Jun 30 20:10:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro29Gln' human Homo sapiens Human physical association physical association nipbl-mau2-3 2 4 unspecified role unspecified role prey prey yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 5 unspecified role unspecified role bait bait Region 1-38 Region 1-38 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast physical association physical association nipbl-mau2-4 1 4 unspecified role unspecified role prey prey Region 1-38 Region 1-38 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Region 32-71 Region 32-71 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 5 unspecified role unspecified role bait bait Region 1-300 Region 1-300 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast physical association physical association