DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219033X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions human Homo sapiens Human tem transmission electron microscopy tem predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219040X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions human Homo sapiens Human tem transmission electron microscopy tem predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219035X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219036X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219038X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219032X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219031X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219039X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219030X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions human Homo sapiens Human light scattering light scattering predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219034X Nature 2011 IMEx Latent TGF-β structure and activation. Latent TGF-β structure and activation. Latent TGF-β structure and activation. Nature 2011 imex curation Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. Only protein-protein interactions human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Shi M., Zhu J., Wang R., Chen X., Mi L., Walz T., Springer TA. DIP original experiment: DIP-219037X Nature 2011 IMEx Latent TGF-β structure and activation. q14766-1 Latent-transforming growth factor beta-binding protein 1 LTBP1 Transforming growth factor beta-1-binding protein 1 LTBP-1L protein protein human Homo sapiens Human MAGAWLRWGLLLWAGLLASSAHGRLRRITYVVHPGPGLAAGALPLSGPPRSRTFNVALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGPPEQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIHHGQTQEYVLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE DIP protein Q14766-1 original sequence version: 109 432489CAC3023754 tgfb1_pig Transforming growth factor beta-1 proprotein TGFB1 protein protein pig Sus scrofa (Pig) Pig MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGDVPPGPLPEAVLALYNSTRDRVAGESVEPEPEPEADYYAKEVTRVLMVESGNQIYDKFKGTPHSLYMLFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNDSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLTRREAIEGFRLSAHCSCDSKDNTLHVEINGFNSGRRGDLATIHGMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS DIP protein P07200 original sequence version: 103 A9FC32859BA6AF06 itb6_human Integrin beta-6 ITGB6 protein protein human Homo sapiens Human MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC DIP protein P18564 original sequence version: 123 DIP protein P18564 original sequence version: 156 EDB7D533EC4C8C4D itav_human Integrin alpha-V ITGAV VNRA Vitronectin receptor subunit alpha MSK8 Vitronectin receptor VTNR protein protein human Homo sapiens Human MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET DIP protein P06756 original sequence version: 136 DIP protein P06756 original sequence version: 145 DIP protein P06756 original sequence version: 174 DIP protein P06756-1 original sequence version: 182 DIP protein P06756 original sequence version: 149 364EE25C5303A2D7 tgfb1_human Transforming growth factor beta-1 proprotein TGFB1 TGFB protein protein human Homo sapiens Human MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS DIP protein P01137 original sequence version: 149 DIP protein P01137 original sequence version: 185 DIP protein P01137 original sequence version: 160 75391614250288FE tgfb1-tgfb1-1 9 13 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 13 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction itgav-itgb6-1 7 14 unspecified role unspecified role unspecified role unspecified role Ectodomain region 22-709 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 15 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 31-992 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction tgfb1-tgfb1-2 5 16 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 16 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction ltbp1-tgfb1-1 10 12 unspecified role unspecified role unspecified role unspecified role Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 16 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction tgfb1-tgfb1-3 4 13 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 13 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction ltbp1-tgfb1-2 6 12 unspecified role unspecified role unspecified role unspecified role Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 16 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction itgav-itgb6-2 1 16 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 16 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 14 unspecified role unspecified role unspecified role unspecified role Ectodomain region 22-709 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 15 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 31-992 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association itgav-itgb6-3 8 16 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 16 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 14 unspecified role unspecified role unspecified role unspecified role Ectodomain region 22-709 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 15 unspecified role unspecified role unspecified role unspecified role Ectodomain Region 31-992 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster physical association physical association tgfb1-tgfb1-4 2 16 unspecified role unspecified role unspecified role unspecified role LAP domain Region 30-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 16 unspecified role unspecified role unspecified role unspecified role TGF-beta1 domain Region 279-390 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction ltbp1-tgfb1-3 3 12 unspecified role unspecified role unspecified role unspecified role Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 16 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction ltbp1-tgfb1-4 11 12 unspecified role unspecified role bait bait Region 1333-1578 Region 1333-1578 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined SBP-tag SBP-tag sbp sbp undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 16 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association