DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature structural & molecular biology 2011 imex curation Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. DIP original experiment: DIP-218609X Nature structural & molecular biology 2011 IMEx ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature structural & molecular biology 2011 imex curation Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. DIP original experiment: DIP-218611X Nature structural & molecular biology 2011 IMEx ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature structural & molecular biology 2011 imex curation Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. DIP original experiment: DIP-218606X Nature structural & molecular biology 2011 IMEx ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature structural & molecular biology 2011 imex curation Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. DIP original experiment: DIP-218608X Nature structural & molecular biology 2011 IMEx ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature structural & molecular biology 2011 imex curation Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. DIP original experiment: DIP-218605X Nature structural & molecular biology 2011 IMEx ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature structural & molecular biology 2011 imex curation Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. DIP original experiment: DIP-218610X Nature structural & molecular biology 2011 IMEx ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature structural & molecular biology 2011 imex curation Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Iwase S., Xiang B., Ghosh S., Ren T., Lewis PW., Cochrane JC., Allis CD., Picketts DJ., Patel DJ., Li H., Shi Y. DIP original experiment: DIP-218607X Nature structural & molecular biology 2011 IMEx ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. h3k9-2 Histone H3 N-terminal Peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ARTKQTARKSTGGKAPRKQLA p46100-1 Transcriptional regulator ATRX ATRX RAD54L XH2 X-linked helicase II ATP-dependent helicase ATRX X-linked nuclear protein Znf-HX protein protein human Homo sapiens Human MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQPVAGGMQPPPLQRAPPPMRSKNPGPSQGKSM DIP protein P46100-1 original sequence version: 163 DIP protein P46100-1 original sequence version: 135 637E341F6A4B29C6 h3-atrx-1 3 8 unspecified role unspecified role bait bait Region 1-14 Region 1-14 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 9 unspecified role unspecified role prey prey ADD domain Region 162-293 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h3-atrx-2 5 8 unspecified role unspecified role bait bait Biotin-tag Biotin-tag biotin tag biotin tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal in vitro In vitro 9 unspecified role unspecified role prey prey ADD domain Region 162-293 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P46100-1:p.Gln219Pro Q219P mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Q P This feature has been corrected as a result of our quality control procedures. The original label was 'Q219P'. Wed May 02 19:57:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln219pro' Tue Jun 30 19:16:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gln219Pro' P46100-1:p.His189Asn H189N mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain H N This feature has been corrected as a result of our quality control procedures. The original label was 'H189N'. Wed May 02 15:57:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'his189asn' Tue Jun 30 19:08:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.His189Asn' P46100-1:p.Glu252Leu E252L mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E L This feature has been corrected as a result of our quality control procedures. The original label was 'E252L'. Wed May 02 17:48:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu252leu' Tue Jun 30 20:14:57 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu252Leu' P46100-1:p.Arg246Cys R246C mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R C This feature has been corrected as a result of our quality control procedures. The original label was 'R246C'. Wed May 02 16:51:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg246cys' Tue Jun 30 16:47:23 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg246Cys' P46100-1:p.Pro190Ala P190A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P190A'. Wed May 02 18:38:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro190ala' Tue Jun 30 18:12:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro190Ala' P46100-1:p.Tyr203Ala Y203A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y203A'. Wed May 02 15:06:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr203ala' Tue Jun 30 20:10:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr203Ala' P46100-1:p.Tyr204Ala Y204A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y204A'. Wed May 02 18:45:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr204ala' Tue Jun 30 16:57:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr204Ala' P46100-1:p.Asp207Ala D207A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D207A'. Wed May 02 18:24:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp207ala' Tue Jun 30 16:53:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp207Ala' ecolx Escherichia coli direct interaction direct interaction atrx-h3-3 4 8 unspecified role unspecified role unspecified role unspecified role Region 1-10 Region 1-10 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role ADD domain Region 167-289 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction atrx-h3-4 7 8 unspecified role unspecified role unspecified role unspecified role Region 1-15 Region 1-15 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role ADD domain Region 167-289 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h3-atrx-3 6 8 unspecified role unspecified role bait bait Biotin-tag Biotin-tag biotin tag biotin tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal K9me2 K9me2 n6me2lys N6,N6-dimethyl-L-lysine (2S)-2-amino-6-(dimethylamino)hexanoic acid MOD_RES N6,N6-dimethyllysine N(zeta)-dimethyllysine N6,N6-dimethyl-L-lysine N6,N6-dimethylated L-lysine epsilon-dimethyllysine lysine derivative Lys(y) Dimethyl N6Me2Lys di-Methylation dimethylk certain certain sequence position certain certain certain sequence position certain in vitro In vitro 9 unspecified role unspecified role prey prey ADD domain Region 162-293 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P46100-1:p.Gln219Pro Q219P mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Q P This feature has been corrected as a result of our quality control procedures. The original label was 'Q219P'. Wed May 02 18:37:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln219pro' Tue Jun 30 16:53:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gln219Pro' P46100-1:p.His189Asn H189N mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain H N This feature has been corrected as a result of our quality control procedures. The original label was 'H189N'. Wed May 02 15:09:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'his189asn' Tue Jun 30 16:48:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.His189Asn' P46100-1:p.Glu252Leu E252L mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E L This feature has been corrected as a result of our quality control procedures. The original label was 'E252L'. Wed May 02 18:52:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu252leu' Tue Jun 30 16:52:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu252Leu' P46100-1:p.Arg246Cys R246C mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R C This feature has been corrected as a result of our quality control procedures. The original label was 'R246C'. Wed May 02 18:06:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg246cys' Tue Jun 30 16:19:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg246Cys' P46100-1:p.Pro190Ala P190A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P190A'. Wed May 02 15:44:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro190ala' Tue Jun 30 17:12:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro190Ala' P46100-1:p.Tyr203Ala Y203A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y203A'. Wed May 02 15:22:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr203ala' Tue Jun 30 16:51:14 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr203Ala' P46100-1:p.Tyr204Ala Y204A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y204A'. Wed May 02 15:38:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr204ala' Tue Jun 30 17:59:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr204Ala' P46100-1:p.Asp207Ala D207A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D207A'. Wed May 02 17:33:22 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp207ala' Tue Jun 30 16:13:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp207Ala' ecolx Escherichia coli direct interaction direct interaction h3-atrx-4 1 8 unspecified role unspecified role bait bait Biotin-tag Biotin-tag biotin tag biotin tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal K9me1 K9me1 n6me1lys N6-methyl-L-lysine (2S)-2-amino-6-methylaminohexanoic acid MOD_RES N6-methyllysine N(zeta)-methyllysine N6-methyl-L-lysine N6-methylated L-lysine epsilon-methyllysine Methyl Methylation N-methyl Lysyl N6Me1Lys certain certain sequence position certain certain certain sequence position certain in vitro In vitro 9 unspecified role unspecified role prey prey ADD domain Region 162-293 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P46100-1:p.Gln219Pro Q219P mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Q P This feature has been corrected as a result of our quality control procedures. The original label was 'Q219P'. Wed May 02 20:07:57 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln219pro' Tue Jun 30 18:13:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gln219Pro' P46100-1:p.His189Asn H189N mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain H N This feature has been corrected as a result of our quality control procedures. The original label was 'H189N'. Wed May 02 20:13:57 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'his189asn' Tue Jun 30 17:34:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.His189Asn' P46100-1:p.Glu252Leu E252L mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E L This feature has been corrected as a result of our quality control procedures. The original label was 'E252L'. Wed May 02 20:09:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu252leu' Tue Jun 30 17:30:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu252Leu' P46100-1:p.Arg246Cys R246C mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R C This feature has been corrected as a result of our quality control procedures. The original label was 'R246C'. Wed May 02 18:29:22 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg246cys' Tue Jun 30 18:37:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg246Cys' P46100-1:p.Pro190Ala P190A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P190A'. Wed May 02 15:58:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro190ala' Tue Jun 30 17:38:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro190Ala' P46100-1:p.Tyr203Ala Y203A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y203A'. Wed May 02 16:28:58 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr203ala' Tue Jun 30 16:01:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr203Ala' P46100-1:p.Tyr204Ala Y204A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y204A'. Wed May 02 16:56:38 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr204ala' Tue Jun 30 16:54:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr204Ala' P46100-1:p.Asp207Ala D207A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D207A'. Wed May 02 19:56:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp207ala' Tue Jun 30 18:44:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp207Ala' ecolx Escherichia coli direct interaction direct interaction h3-atrx-5 2 8 unspecified role unspecified role bait bait Biotin-tag Biotin-tag biotin tag biotin tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal K9me3 K9me3 n6me3+lys N6,N6,N6-trimethyl-L-lysine (5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium 2-amino-6-(trimethylammonio)hexanoic acid 5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium MOD_RES N6,N6,N6-trimethyllysine N(zeta)-trimethyllysine N6,N6,N6-trimethyl-L-lysine N6,N6,N6-trimethylated L-lysine N6,N6,N6-trimethyllysin-N6-ium N6,N6,N6-trimethyllysine cation epsilon-trimethyllysine N-trimethylation (of lysine) N6Me3+Lys Trimethyl tri-Methylation certain certain sequence position certain certain certain sequence position certain in vitro In vitro 9 unspecified role unspecified role prey prey ADD domain Region 162-293 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P46100-1:p.Gln219Pro Q219P mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Q P This feature has been corrected as a result of our quality control procedures. The original label was 'Q219P'. Wed May 02 16:26:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln219pro' Tue Jun 30 17:56:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gln219Pro' P46100-1:p.His189Asn H189N mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain H N This feature has been corrected as a result of our quality control procedures. The original label was 'H189N'. Wed May 02 18:13:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'his189asn' Tue Jun 30 18:09:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.His189Asn' P46100-1:p.Glu252Leu E252L mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E L This feature has been corrected as a result of our quality control procedures. The original label was 'E252L'. Wed May 02 15:28:39 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu252leu' Tue Jun 30 17:18:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu252Leu' P46100-1:p.Arg246Cys R246C mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R C This feature has been corrected as a result of our quality control procedures. The original label was 'R246C'. Wed May 02 19:21:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg246cys' Tue Jun 30 19:50:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg246Cys' P46100-1:p.Pro190Ala P190A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P190A'. Wed May 02 17:07:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro190ala' Tue Jun 30 18:07:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro190Ala' P46100-1:p.Tyr203Ala Y203A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y203A'. Wed May 02 14:43:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr203ala' Tue Jun 30 16:53:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr203Ala' P46100-1:p.Tyr204Ala Y204A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y204A'. Wed May 02 20:04:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr204ala' Tue Jun 30 15:35:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr204Ala' P46100-1:p.Asp207Ala D207A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D207A'. Wed May 02 16:07:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp207ala' Tue Jun 30 18:25:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp207Ala' ecolx Escherichia coli direct interaction direct interaction