DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nature structural & molecular biology 2011 imex curation Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. DIP original experiment: DIP-218590X Nature structural & molecular biology 2011 IMEx Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nature structural & molecular biology 2011 imex curation Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. DIP original experiment: DIP-218587X Nature structural & molecular biology 2011 IMEx Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nature structural & molecular biology 2011 imex curation Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. DIP original experiment: DIP-218589X Nature structural & molecular biology 2011 IMEx Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nature structural & molecular biology 2011 imex curation Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Vendome J., Posy S., Jin X., Bahna F., Ahlsen G., Shapiro L., Honig B. DIP original experiment: DIP-218588X Nature structural & molecular biology 2011 IMEx Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. cadh2_mouse Cadherin-2 Cdh2 Neural cadherin protein protein mouse Mus musculus Mouse MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD DIP protein P15116 original sequence version: 114 DIP protein P15116 original sequence version: 105 DIP protein P15116 original sequence version: 125 DIP protein P15116 original sequence version: 113 DIP protein P15116 original sequence version: 117 DIP protein P15116 original sequence version: 147 BDAB8063A23E1F13 cadh1_mouse Cadherin-1 Epithelial cadherin Uvomorulin ARC-1 Cdh1 protein protein mouse Mus musculus Mouse MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD DIP protein P09803 original sequence version: 92 DIP protein P09803 original sequence version: 116 DIP protein P09803 original sequence version: 124 DIP protein P09803 original sequence version: 128 DIP protein P09803 original sequence version: 141 DIP protein P09803 original sequence version: 174 7A6444148D3D5983 cad11_mouse Cadherin-11 Cdh11 Cad-11 OSF-4 Osteoblast cadherin protein protein mouse Mus musculus Mouse MKENYCLQAALVCLSMLYHSQAFALERRSHLHPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHEIYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGIELFEITTDYETQDGVVKLKKPVDFETKRAYSLKIEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNISVFAAEIHNRHQETKVPVAIRVLDVNDNAPKFAAPYEGFICESDHPKALSNQPIVTVSADDQDDTANGPRFIFSLPPEIMHNPNFTVRDNRDNTAGVYARRGGFSRQKQDFYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS DIP protein P55288 original sequence version: 92 cdh1-15 2 6 unspecified role unspecified role unspecified role unspecified role EC1-2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdh11-1 1 7 unspecified role unspecified role unspecified role unspecified role EC1-2 domain Region 54-268 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P55288:p.Phe61Ala F61A mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F61A'. Wed May 02 19:33:11 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe61ala' Tue Jun 30 16:57:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe61Ala' ecolx Escherichia coli direct interaction direct interaction cdh1-16 4 6 unspecified role unspecified role unspecified role unspecified role EC1-2 domain Region 157-369 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain P09803:p.Trp158Phe W158F mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain W F This feature has been corrected as a result of our quality control procedures. The original label was 'W158F'. Wed May 02 15:55:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp158phe' Tue Jun 30 19:24:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Trp158Phe' P09803:p.Pro161_Pro162delinsAlaAla P161A/S/G/P162A/S/G mutation increasing strength mutation increasing interaction strength mutation increasing strength mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain PP AA Wed May 02 14:50:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro_pro161-162ala_ala' Tue Jun 30 17:45:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro161_Pro162delinsAlaAla' P09803:p.Pro161Ala P161A mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P161A'. Wed May 02 15:43:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro161ala' Tue Jun 30 15:53:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro161Ala' P09803:p.Pro162Ala P162A mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P162A'. Wed May 02 16:52:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro162ala' Tue Jun 30 18:25:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro162Ala' P09803:p.Pro161_Pro162delinsSerSer mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain PP SS Wed May 02 14:24:42 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro_pro161-162ser_ser' Tue Jun 30 19:34:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro161_Pro162delinsSerSer' P09803:p.Pro161_Pro162delinsGlyGly mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain PP GG Wed May 02 19:10:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro_pro161-162gly_gly' Tue Jun 30 20:20:26 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro161_Pro162delinsGlyGly' ecolx Escherichia coli direct interaction direct interaction cdh2-7 3 5 unspecified role unspecified role unspecified role unspecified role EC1-2 domain Region 160-374 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P15116:p.[Pro164Ala;Pro165Ala] P164A/P165A mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain P A certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P164A/P165A'. Wed May 02 19:08:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro164ala,pro165ala' Tue Jun 30 17:16:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Pro164Ala;Pro165Ala]' ecolx Escherichia coli direct interaction direct interaction