DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Streptococcal M1 protein constructs a pathological host fibrinogen network. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature 2011 imex curation Macheboeuf P., Buffalo C., Fu CY., Zinkernagel AS., Cole JN., Johnson JE., Nizet V., Ghosh P. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Macheboeuf P., Buffalo C., Fu CY., Zinkernagel AS., Cole JN., Johnson JE., Nizet V., Ghosh P. DIP original experiment: DIP-219120X Nature 2011 IMEx Streptococcal M1 protein constructs a pathological host fibrinogen network. Streptococcal M1 protein constructs a pathological host fibrinogen network. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature 2011 imex curation Macheboeuf P., Buffalo C., Fu CY., Zinkernagel AS., Cole JN., Johnson JE., Nizet V., Ghosh P. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Macheboeuf P., Buffalo C., Fu CY., Zinkernagel AS., Cole JN., Johnson JE., Nizet V., Ghosh P. DIP original experiment: DIP-219121X Nature 2011 IMEx Streptococcal M1 protein constructs a pathological host fibrinogen network. fiba_human Fibrinogen alpha chain FGA protein protein human Homo sapiens Human MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ DIP protein P02671 original sequence version: 118 DIP protein P02671-1 original sequence version: 160 DIP protein P02671 original sequence version: 157 EA73A81204D8AEC4 q99xv0_strp1 emm1 SPy_2018 protein protein strp1 Streptococcus pyogenes serotype M1 MAKNNTNRHYSLRKLKTGTASVAVALTVLGAGFANQTEVKANGDGNPREVIEDLAANNPAIQNIRLRYENKDLKARLENAMEVAGRDFKRAEELEKAKQALEDQRKDLETKLKELQQDYDLAKESTSWDRQRLEKELEEKKEALELAIDQASRDYHRATALEKELEEKKKALELAIDQASQDYNRANVLEKELETITREQEINRNLLGNAKLELDQLSSEKEQLTIEKAKLEEEKQISDASRQSLRRDLDASREAKKQVEKDLANLTAELDKVKEDKQISDASRQGLRRDLDASREAKKQVEKDLANLTAELDKVKEEKQISDASRQGLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEQLAKQAEELAKLRAGKASDSQTPDTKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN 99DD63DDE3799F3C fibg_human Fibrinogen gamma chain FGG PRO2061 protein protein human Homo sapiens Human MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTIGEGQQHHLGGAKQVRPEHPAETEYDSLYPEDDL DIP protein P02679 original sequence version: 118 DIP protein P02679 original sequence version: 155 1787204904E0D4BB fibb_human Fibrinogen beta chain FGB protein protein human Homo sapiens Human MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ DIP protein P02675 original sequence version: 111 DIP protein P02675 original sequence version: 153 DIP protein P02675 original sequence version: 149 DIP protein P02675 original sequence version: 147 B92FFB9976AB53C5 fga-fgb-5 2 5 unspecified role unspecified role unspecified role unspecified role Fragment D domain Region 114-432 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 6 unspecified role unspecified role unspecified role unspecified role Fragment D domain Region 164-491 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 3 unspecified role unspecified role unspecified role unspecified role Fragment D domain Region 130-216 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 4 unspecified role unspecified role unspecified role unspecified role BC1 domain Region 128-263 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain A domain Region 42-132 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli physical association physical association fga-fgb-6 1 5 unspecified role unspecified role unspecified role unspecified role Fragment D domain Region 114-432 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 6 unspecified role unspecified role unspecified role unspecified role Fragment D domain Region 164-491 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 3 unspecified role unspecified role unspecified role unspecified role Fragment D domain Region 130-216 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 4 unspecified role unspecified role unspecified role unspecified role BC1 domain Region 128-263 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain A domain Region 42-132 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli physical association physical association