DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Omori Y., Chaya T., Katoh K., Kajimura N., Sato S., Muraoka K., Ueno S., Koyasu T., Kondo M., Furukawa T. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Omori Y., Chaya T., Katoh K., Kajimura N., Sato S., Muraoka K., Ueno S., Koyasu T., Kondo M., Furukawa T. DIP original experiment: DIP-220675X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Omori Y., Chaya T., Katoh K., Kajimura N., Sato S., Muraoka K., Ueno S., Koyasu T., Kondo M., Furukawa T. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Omori Y., Chaya T., Katoh K., Kajimura N., Sato S., Muraoka K., Ueno S., Koyasu T., Kondo M., Furukawa T. DIP original experiment: DIP-220674X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. mak_mouse Serine/threonine-protein kinase MAK Mak Male germ cell-associated kinase Protein kinase RCK Rck protein protein mouse Mus musculus Mouse MNRYTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGSSAHHLDTKQTLHKQLQPLEPKPSSSERDPKPLPNILDQPAGQPQPKQGHQPLQTIQPPQNTVTHPPPKQQGHQKPPQTMFPSIIKTIPVNSVSTLGHKGARRRWGQTVFKSGDSCDDIEDDLGASHSKKPSMEACKEKKKESPFRFPDSGLPVSNHFKGENRNLHASVSLKSDPNLSTASTAKQYYLKQSRYLPGVNPKNVSLVAGGKDINSHSWNNQLFPKSLGSMGADLSFKRSNAAGNLGSYTTYNQTGYMPSFLKKEVGSAGQRIQLAPLGASASDYTWSTKTGRGQFSGRTYNPTAKNLNIVNRTQPVPSVHGRTDWVAKYGGHR This sequence has been withdrawn from Uniprot. DB7E3B758F8FEA69 q8ixn4_human MAK protein protein human Homo sapiens Human MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRQQVKMAVISLSAHQFPTL DIP protein Q8IXN4 original sequence version: 67 16B7B633E2C5C7DF rp1_mouse Oxygen-regulated protein 1 Rp1 Orp1 Rp1h Retinitis pigmentosa RP1 protein homolog protein protein mouse Mus musculus Mouse MSDTPSTSFSMIHLTSEGQVPSPRHSNITHPVVAKRISFYKSGDPQFGGVRVVVNPRSFKTFDALLDSLSRKVPLPFGVRNISTPRGRHSITRLEELEDGKSYVCSHNKKVLPVDLDKARRRPRPWLSSRSISTHVQLCPATANMSTMAPGMLRAPRRLVVFRNGDPKNKHVVLLSRRITQSFEAFLQYLTQVMQCPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPAKLPGISHRVHQKGKAKIEKRKMSTHMPSDLRPQTDSLISEKTYDCFSDFSVAPENYLALETHESQSLSTYPSEDDVEKSIVFNQDGTMTVVMKVRFKIKEEETVKWTTTVNRAGLSNNDEKNKKSSYPGKTDYGPSSLKLEACSLPEDIVDTTQQGSLTEEENTQMTEQQALSCSSASWENASMETDIQESQKQVKHFYRPPTPGPRRMRQKKSVIGTVTVVSETEVQEKQFSYSEERKGGEKSEYHMFTHSCSKMSSVSNKLVQIGSDNEMESALERTRESGSLKSQAINAGAIEITSQKVLKMCHNNALPSTAPENSVVEEGTDNSAVSGTATIKHFRTCGNANDSFSSITADSTPTSVNNYSNDRNISELPSVGSPVLTMRLVNEFAHCGLTEKPENRKKVLSSSASKKKKKKSQQRMITSNDKKKVIETKGPPNIAGKIPRAGTTAQERLLQESDCPDKGGRVCEQGLNISPMAIESNNFFPKSNPTFSKNFYKNKLNTFQNPKTQKLLAKRKSRPRKIVSTERLRKQEIGQEDKILLHSDSKLCESHLEKQSLFHVFNILEEDQKVLHRPPFQVEKVARNLKGMAKKSLVPKVNDLHIMLRNQKKQMGVKLKSGAEVSEQHVTTRADPLASLKKPDFPEGIPHHSGKSYVKRWLQNINSYPDFEHRKSGPLCQNRSDVVNYNRNGFLGNNLHTTSSKGNGFLMESNKSKTKNDNWSGNTNQETGKSLVAKDNGEELNKHHCESQNGSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKSRPEVKLVYQEMNFATKRQSIEVAIQVDTMGENVLKDYLPALLLRHLEAFVPNNQKHQNGISQIPGSLAEVVFPSVIDNSSTNLLLAWLLVLNLKRTMNSFCQSDAHKMTNRPSETAALLEVLKHVAITEEADDLKAAVANLMESTKTCSGSSGREQDMLPVNCTASSLHSVDECNENGSAQKTLLDEGYSVMGDCTSEMVSKSCNSSCEMHMVSKTNPPKQVDDQSDGLLTSNSCTVSQRSTGACFLTDGVYSHEACAQKEGVYEGACLSDETHIPIRDCHTIHSVHSKENKCTDDLESTEELKTVDKVPKGLSILADSMYKNDSNVSTFQNVNKLSSQRTLLSKTYLDSDKDYSPLEEFQNCPRKKIVNKKKSISSDKEESRTSEEPRSITNSMTSSERNAISELESFEELESQDTSIFNMNVRAEKKSTKETMQKQSEARMSSELINVSGRKIIEQERRNTAILETTARGQVTPPSLAFCYDSNKNTEKEISEGETKMRVKKMVDSMENESYSESSLNFKKHHRSPGTLDWSDYGSDSESGYPCKASSNSHNDDSGQEKEPTRGIVKRAIEKLYGKAEIIKPPFFHGSIHKSQVCPYNSVEVQCAKKTNFYESECQSLVSSEQVSRSSLIFQEFPQVDANGMGDSFGDSSIENVTKSSAHDRVFTEKENGKLIDNGKWLLRENHLWRVSSDNPGMYGNADTTSVDTLIDKNSIEVPYSHFGELAPGPTMAELSSSEIEEMTQPLEVKCNYFNFPHGSDSEPFGEDFPDAQNKTCPKEKIPNHHTEEKGNYPSERLCTSVTQAFVSAGNKVHPVCSDAIKTQPLPGSNITHGALQEGDSLDKLYALCGQHCPILTVIIQPVNEESRGFAYRKDSDIENSLDFQLWMKIYPFMPQSKKHVFRSDGRNVSVGEEFAGNVIGDLCDQLYFKSMIDLVDQRANSLGKEINLKKFQLYLKKSFSDPLSTSLLVVENRNSVSLSPSSWTDNFKSIDENNNFLNRLPNSSKNPNQVVRENTNFQFHLELFGQVYLLDICQVEKPLNIKTRSKLEMYYILEGEVLFIWEEEK DIP protein P56716 original sequence version: 72 mint Could have a role in the differentiation of photoreceptor cells CA5301316633BD62 mak-rp1-1 2 5 enzyme target enzyme target substrate substrate unspecified role unspecified role N-terminal domain Region 1-661 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain C-terminal domain Region 1381-2095 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 4 enzyme enzyme unspecified role unspecified role in vitro In vitro phosphorylation phosphorylation reaction phosphorylation rp1-mmak-1 1 5 unspecified role unspecified role bait bait N-terminal domain Region 1-661 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 3 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association