DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. DIP original experiment: DIP-254104X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. Only protein-protein interactions in vitro In vitro comigration in sds comigration in sds page comigration in sds predetermined predetermined participant predetermined Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. DIP original experiment: DIP-254105X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. DIP original experiment: DIP-254103X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. DIP original experiment: DIP-254108X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. Only protein-protein interactions human Homo sapiens Human comigration in sds comigration in sds page comigration in sds western blot western blot Immuno blot Immuno blot Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. DIP original experiment: DIP-254106X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen PC., Hu X., Liu J., Qin J., Xiao L., Huang XQ., Zhang J., Li DW. DIP original experiment: DIP-254107X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. pax6_human Paired box protein Pax-6 Oculorhombin Aniridia type II protein PAX6 AN2 protein protein human Homo sapiens Human MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ DIP protein P26367 original sequence version: 146 C33CDD2C1B13C397 sumo1_human Small ubiquitin-related modifier 1 SUMO1 Sentrin Ubiquitin-like protein SMT3C Ubiquitin-homology domain protein PIC1 Ubiquitin-like protein UBL1 GAP-modifying protein 1 SMT3 homolog 3 SMT3C SMT3H3 UBL1 OK/SW-cl.43 protein protein human Homo sapiens Human MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV DIP protein P63165 original sequence version: 36 DIP protein P63165 original sequence version: 40 DIP protein P63165 original sequence version: 124 DIP protein P63165 original sequence version: 125 DIP protein P63165 original sequence version: 83 DIP protein P63165 original sequence version: 85 DIP protein P63165 original sequence version: 81 DIP protein P63165 original sequence version: 84 DIP protein P63165 original sequence version: 103 DIP protein P63165 original sequence version: 100 DIP protein P63165 original sequence version: 95 DIP protein P63165 original sequence version: 98 DIP protein P63165 original sequence version: 101 DIP protein P63165-1 original sequence version: 131 DIP protein P63165 original sequence version: 102 DIP protein P63165 original sequence version: 122 DIP protein P63165 original sequence version: 62 DIP protein P63165 original sequence version: 119 DIP protein P63165 original sequence version: 82 89BE97D2D054FB33 sumo1_mouse Small ubiquitin-related modifier 1 Sumo1 Smt3c Smt3h3 Ubl1 Ubiquitin-like protein SMT3C SMT3 homolog 3 Ubiquitin-homology domain protein PIC1 protein protein mouse Mus musculus Mouse MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV DIP protein P63166 original sequence version: 51 DIP protein P63166 original sequence version: 69 DIP protein P63166 original sequence version: 82 DIP protein P63166 original sequence version: 35 89BE97D2D054FB33 pax6_mouse Paired box protein Pax-6 Pax-6 Sey Pax6 Oculorhombin protein protein mouse Mus musculus Mouse MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ DIP protein P63015 original sequence version: 92 C33CDD2C1B13C397 p26367-1 Paired box protein Pax-6 PAX6 AN2 Aniridia type II protein Oculorhombin protein protein human Homo sapiens Human MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ DIP protein P26367-1 original sequence version: 146 sumo1-pax6-1 4 11 unspecified role unspecified role prey prey Region 137-422 Region 137-422 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P26367-1:p.Lys227Arg K227R mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K227R'. Wed May 02 15:12:11 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys227arg' Tue Jun 30 18:38:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys227Arg' mouse Mus musculus Mouse 9 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association pax6-sumo1-1 3 10 unspecified role unspecified role bait bait mouse Mus musculus Mouse 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association pax6-sumo1-2 5 7 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human 8 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction sumo1-pax6-2 1 10 unspecified role unspecified role prey prey mouse Mus musculus Mouse 9 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association pax6-sumo1-3 6 11 unspecified role unspecified role bait bait Region 137-422 Region 137-422 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P26367-1:p.Lys227Arg K227R mutation disrupting mutation disrupting interaction mutation disrupting substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K227R'. Wed May 02 15:27:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys227arg' Tue Jun 30 17:51:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys227Arg' mouse Mus musculus Mouse 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association pax6-sumo1-4 2 8 unspecified role unspecified role unspecified role unspecified role 11 unspecified role unspecified role unspecified role unspecified role Region 137-422 Region 137-422 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro direct interaction direct interaction