DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. Only protein-protein interactions nicbe Nicotiana benthamiana solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. DIP original experiment: DIP-220610X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. Only protein-protein interactions nicbe Nicotiana benthamiana molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. DIP original experiment: DIP-220611X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. Only protein-protein interactions human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. DIP original experiment: DIP-220612X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proceedings of the National Academy of Sciences of the United States of America 2010 imex curation Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. Only protein-protein interactions human Homo sapiens Human solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Geyer BC., Kannan L., Garnaud PE., Broomfield CA., Cadieux CL., Cherni I., Hodgins SM., Kasten SA., Kelley K., Kilbourne J., Oliver ZP., Otto TC., Puffenberger I., Reeves TE., Robbins N., Woods RR., Soreq H., Lenz DE., Cerasoli DM., Mor TS. DIP original experiment: DIP-220609X Proceedings of the National Academy of Sciences of the United States of America 2010 IMEx Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. chle_human Cholinesterase BCHE CHE1 Acylcholine acylhydrolase Choline esterase II Butyrylcholine esterase Pseudocholinesterase protein protein human Homo sapiens Human MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL DIP protein P06276 original sequence version: 99 DIP protein P06276 original sequence version: 129 Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait mint C9836409D9057F27 bche-4 4 5 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction bche-5 1 5 unspecified role unspecified role unspecified role unspecified role nicbe Nicotiana benthamiana direct interaction direct interaction bche-6 2 5 unspecified role unspecified role unspecified role unspecified role nicbe Nicotiana benthamiana direct interaction direct interaction bche-7 3 5 unspecified role unspecified role unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction