DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS biology 2010 imex curation Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. DIP original experiment: DIP-216184X PLoS biology 2010 IMEx Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS biology 2010 imex curation Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. Only protein-protein interactions chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. DIP original experiment: DIP-216187X PLoS biology 2010 IMEx Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS biology 2010 imex curation Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. Only protein-protein interactions chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. DIP original experiment: DIP-216186X PLoS biology 2010 IMEx Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS biology 2010 imex curation Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Mazella J., Pétrault O., Lucas G., Deval E., Béraud-Dufour S., Gandin C., El-Yacoubi M., Widmann C., Guyon A., Chevet E., Taouji S., Conductier G., Corinus A., Coppola T., Gobbi G., Nahon JL., Heurteaux C., Borsotto M. DIP original experiment: DIP-216185X PLoS biology 2010 IMEx Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. kcnk2_mouse Potassium channel subfamily K member 2 Kcnk2 Outward rectifying potassium channel protein TREK-1 TREK-1 K(+) channel subunit Two pore potassium channel TPKC1 protein protein mouse Mus musculus Mouse MLASASRERPGYTAGVAAPDLLDPKSAAQNSKPRLSFSSKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQTFIAQHACVNSTELDELIQQIVAAINAGIIPLGNSSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREVLPPLLKAESIYLNGLTPHCAGEDIAVIENMK DIP protein P97438 original sequence version: 83 mint 8C298C01F5BDB61A sort_mouse Sortilin Sort1 Neurotensin receptor 3 protein protein mouse Mus musculus Mouse MERPRGAADGLLRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPPLLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHVFDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCKADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANEDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSTLSEDNSIQSMITFDQGGRWEHLRKPENSKCDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTESFITRQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQPSVCPCSLEDFLCDFGYFRPENASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDKCQGGMNPAREVKDLKKKCTSNFLNPTKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEADGVEALDSTSHAKSGYHDDSDEDLLE DIP protein Q6PHU5 original sequence version: 45 DIP protein Q6PHU5 original sequence version: 62 Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi mint 9A7A73C6FE1C8201 sort1-kcnk2-1 1 5 unspecified role unspecified role prey prey mouse Mus musculus Mouse 6 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association kcnk2-sort1-1 2 5 unspecified role unspecified role bait bait chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey 6 unspecified role unspecified role prey prey chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey physical association physical association kcnk2-sort1-2 4 5 unspecified role unspecified role bait bait mouse Mus musculus Mouse 6 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association sort1-kcnk2-2 3 5 unspecified role unspecified role prey prey chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey 6 unspecified role unspecified role bait bait chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey physical association physical association