DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro atomic force microsc atomic force microscopy AFM AFM atomic force microsc predetermined predetermined participant predetermined Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218312X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro fluorescence spectr classical fluorescence spectroscopy fluorescence spectr predetermined predetermined participant predetermined Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218313X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro comigration in sds comigration in sds page comigration in sds western blot western blot Immuno blot Immuno blot Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218314X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro comig non denat gel comigration in non denaturing gel electrophoresis comig non denat gel weight by comassie molecular weight estimation by coomasie staining weight by comassie Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218315X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro dls dynamic light scattering dls predetermined predetermined participant predetermined Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218318X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218311X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218316X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature structural & molecular biology 2010 imex curation Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO., Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Ahmed M., Davis J., Aucoin D., Sato T., Ahuja S., Aimoto S., Elliott JI., Van Nostrand WE., Smith SO. Alzheimers - Interactions investigated in the context of Alzheimers disease DIP original experiment: DIP-218317X Nature structural & molecular biology 2010 IMEx Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. p05067-pro_0000000092 Amyloid-beta protein 42 Alzheimer disease amyloid protein Cerebral vascular amyloid peptide APP A4 AD1 ABPP PreA4 Protease nexin-II APPI Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 672 713 3AC85563D7858C37 abeta142-6 4 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta142-7 6 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta142-8 7 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta142-9 1 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta142-10 8 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta142-11 2 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta142-12 5 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta142-13 3 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction