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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Four generations of transition-state analogues for human purine nucleoside phosphorylase.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="20212140" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0913439107" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15840592" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-15232" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Four generations of transition-state analogues for human purine nucleoside phosphorylase.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2010</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Ho MC.,  Shi W.,  Rinaldo-Matthis A.,  Tyler PC.,  Evans GB.,  Clinch K.,  Almo SC.,  Schramm VL.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-15232" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="3K8O" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-216340X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="3K8Q" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="20212140" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0913439107" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="562">
            <names>
              <shortLabel>ecolx</shortLabel>
              <fullName>Escherichia coli</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Ho MC., Shi W., Rinaldo-Matthis A., Tyler PC., Evans GB., Clinch K., Almo SC., Schramm VL.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-216340X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2010</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Four generations of transition-state analogues for human purine nucleoside phosphorylase.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>pnph_human</shortLabel>
          <fullName>Purine nucleoside phosphorylase</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Inosine phosphorylase</alias>
          <alias type="gene name" typeAc="MI:0301">PNP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">NP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Inosine-guanosine phosphorylase</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P00491" version="SP_85" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000354532" version="SP_221" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15160" version="SP_85" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5PZ03" version="SP_85" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2R8S5" version="SP_103" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DS00" version="SP_128" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-712238" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001882" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002060" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004731" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006139" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006148" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006149" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006157" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006166" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006204" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006738" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006955" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009165" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019428" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032743" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034418" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034774" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042102" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042301" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043101" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046059" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046638" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0047975" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" version="SP_221"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1904813" version="SP_221"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000845" version="SP_221"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011268" version="SP_221"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011270" version="SP_221"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018099" version="SP_221"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035994" version="SP_221"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P00491" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1M73" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1PF7" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1PWY" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1RCT" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1RFG" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1RR6" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1RSZ" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1RT9" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1ULA" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1ULB" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1V2H" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1V3Q" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1V41" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1V45" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1YRY" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2A0W" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2A0X" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2A0Y" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OC4" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OC9" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2ON6" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2Q7O" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3BGS" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3D1V" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3GB9" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3GGS" version="SP_221"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000198805" version="SP_221" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000361505" version="SP_221" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000255" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3K8O" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3K8Q" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3PHB" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4EAR" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3INY" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4EB8" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ECE" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GKA" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5ETJ" version="SP_221"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UGF" version="SP_221"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6798695" version="SP_221"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-74217" version="SP_221"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-74259" version="SP_221"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000261.2"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-50406N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P00491 original sequence version: 119</attribute>
          <attribute name="crc64">91622FB1D26479D3</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-15232-1">
        <names>
          <shortLabel>pnp-4</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-185726E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15840613" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-15232-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>