DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217026X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217025X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217032X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217033X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217024X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217027X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217031X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217029X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217030X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217023X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Two-step adhesive binding by classical cadherins. Nature structural & molecular biology 2010 imex curation Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Harrison OJ., Bahna F., Katsamba PS., Jin X., Brasch J., Vendome J., Ahlsen G., Carroll KJ., Price SR., Honig B., Shapiro L. DIP original experiment: DIP-217028X Nature structural & molecular biology 2010 IMEx Two-step adhesive binding by classical cadherins. cadh2_mouse Cadherin-2 Cdh2 Neural cadherin protein protein mouse Mus musculus Mouse MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKFLIYAQDKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD DIP protein P15116 original sequence version: 114 DIP protein P15116 original sequence version: 105 DIP protein P15116 original sequence version: 125 DIP protein P15116 original sequence version: 113 DIP protein P15116 original sequence version: 117 DIP protein P15116 original sequence version: 147 BDAB8063A23E1F13 cadh1_mouse Cadherin-1 Epithelial cadherin Uvomorulin ARC-1 Cdh1 protein protein mouse Mus musculus Mouse MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD DIP protein P09803 original sequence version: 92 DIP protein P09803 original sequence version: 116 DIP protein P09803 original sequence version: 124 DIP protein P09803 original sequence version: 128 DIP protein P09803 original sequence version: 141 DIP protein P09803 original sequence version: 174 7A6444148D3D5983 q3knz1_mouse Cdh6 protein protein mouse Mus musculus Mouse MRTYRYFLLLFWVGQPYPTFSNPLSKRTSGFPAKRKALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAVNRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHEMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPHVEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKLAYILQIREDARINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLRAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAMEDSKSRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGGMDSDKDS DIP protein Q3KNZ1 original sequence version: 32 cdh1-cdh1-1 1 13 unspecified role unspecified role prey prey EC1-EC2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 13 unspecified role unspecified role bait bait EC1-EC2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P09803:p.Lys170Glu K170E mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K170E'. Wed May 02 19:56:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys170glu' Tue Jun 30 19:16:42 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys170Glu' P09803:p.Tyr298Arg Y298R mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y R This feature has been corrected as a result of our quality control procedures. The original label was 'Y298R'. Wed May 02 14:49:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr298arg' Tue Jun 30 19:47:25 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr298Arg' ecolx Escherichia coli direct interaction direct interaction cdh1-7 10 13 unspecified role unspecified role unspecified role unspecified role EC1-EC2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdh6-1 9 14 unspecified role unspecified role unspecified role unspecified role EC1-EC2 domain Region 54-260 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q3KNZ1:p.[Trp57Ala;Met241Asp] M241D/W57A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain W A certain certain sequence position certain certain certain sequence position certain M D This feature has been corrected as a result of our quality control procedures. The original label was 'M241D/W57A'. Wed May 02 16:06:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp57ala,met241asp' Tue Jun 30 20:25:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Trp57Ala;Met241Asp]' ecolx Escherichia coli direct interaction direct interaction cdh6-2 11 14 unspecified role unspecified role unspecified role unspecified role EC1-EC2 domain Region 54-260 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdh6-cdh6-1 7 14 unspecified role unspecified role prey prey EC1-EC2 domain Region 54-260 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 14 unspecified role unspecified role bait bait EC1-EC2 domain Region 54-260 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q3KNZ1:p.Met241Asp M241D mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain M D This feature has been corrected as a result of our quality control procedures. The original label was 'M241D'. Wed May 02 15:36:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'met241asp' Tue Jun 30 20:04:14 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Met241Asp' ecolx Escherichia coli direct interaction direct interaction cdh1-8 5 13 unspecified role unspecified role unspecified role unspecified role EC1-EC2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P09803:p.[Trp158Ala;Lys170Glu] K170E/W158A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K E certain certain sequence position certain certain certain sequence position certain W A This feature has been corrected as a result of our quality control procedures. The original label was 'K170E/W158A'. Wed May 02 19:04:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp158ala,lys170glu' Tue Jun 30 16:34:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Trp158Ala;Lys170Glu]' ecolx Escherichia coli direct interaction direct interaction cdh6-3 8 14 unspecified role unspecified role unspecified role unspecified role EC1-EC2 domain Region 54-260 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdh1-cdh1-2 6 13 unspecified role unspecified role prey prey EC1-EC2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P09803:p.Lys170Glu K170E mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K170E'. Wed May 02 20:16:08 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys170glu' Tue Jun 30 20:16:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys170Glu' P09803:p.Tyr298Arg Y298R mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y R This feature has been corrected as a result of our quality control procedures. The original label was 'Y298R'. Wed May 02 15:19:48 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr298arg' Tue Jun 30 20:23:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr298Arg' P09803:p.Lys170Ser K170S mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K S This feature has been corrected as a result of our quality control procedures. The original label was 'K170S'. Wed May 02 14:28:12 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys170ser' Tue Jun 30 19:57:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys170Ser' ecolx Escherichia coli 13 unspecified role unspecified role bait bait EC1-EC2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdh1-9 2 13 unspecified role unspecified role unspecified role unspecified role EC1-EC2 domain Region 157-369 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdh6-cdh6-2 3 14 unspecified role unspecified role prey prey EC1-EC2 domain Region 54-260 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q3KNZ1:p.Met241Asp M241D mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain M D This feature has been corrected as a result of our quality control procedures. The original label was 'M241D'. Wed May 02 18:48:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'met241asp' Tue Jun 30 17:10:06 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Met241Asp' ecolx Escherichia coli 14 unspecified role unspecified role bait bait EC1-EC2 domain Region 54-260 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction cdh2-4 4 12 unspecified role unspecified role unspecified role unspecified role EC1-EC2 domain Region 160-374 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction