DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009 imex curation Dang L., White DW., Gross S., Bennett BD., Bittinger MA., Driggers EM., Fantin VR., Jang HG., Jin S., Keenan MC., Marks KM., Prins RM., Ward PS., Yen KE., Liau LM., Rabinowitz JD., Cantley LC., Thompson CB., Vander Heiden MG., Su SM. Only protein-protein interactions ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Dang L., White DW., Gross S., Bennett BD., Bittinger MA., Driggers EM., Fantin VR., Jang HG., Jin S., Keenan MC., Marks KM., Prins RM., Ward PS., Yen KE., Liau LM., Rabinowitz JD., Cantley LC., Thompson CB., Vander Heiden MG., Su SM. DIP original experiment: DIP-219673X Nature 2009 IMEx Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009 imex curation Dang L., White DW., Gross S., Bennett BD., Bittinger MA., Driggers EM., Fantin VR., Jang HG., Jin S., Keenan MC., Marks KM., Prins RM., Ward PS., Yen KE., Liau LM., Rabinowitz JD., Cantley LC., Thompson CB., Vander Heiden MG., Su SM. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Dang L., White DW., Gross S., Bennett BD., Bittinger MA., Driggers EM., Fantin VR., Jang HG., Jin S., Keenan MC., Marks KM., Prins RM., Ward PS., Yen KE., Liau LM., Rabinowitz JD., Cantley LC., Thompson CB., Vander Heiden MG., Su SM. DIP original experiment: DIP-219672X Nature 2009 IMEx Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. idhc_human Isocitrate dehydrogenase [NADP] cytoplasmic Cytosolic NADP-isocitrate dehydrogenase Oxalosuccinate decarboxylase NADP(+)-specific ICDH IDP IDH1 PICD protein protein human Homo sapiens Human MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL DIP protein O75874 original sequence version: 127 DIP protein O75874 original sequence version: 168 60428B0B6E5851DC idh1-1 2 3 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction idh1-2 1 3 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction