DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. DIP original experiment: DIP-134648X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. Only protein-protein interactions ecolx Escherichia coli ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. DIP original experiment: DIP-134650X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. Only protein-protein interactions ecolx Escherichia coli x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. DIP original experiment: DIP-134646X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. Only protein-protein interactions in vitro In vitro ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. DIP original experiment: DIP-134651X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. Only protein-protein interactions ecolx Escherichia coli solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. DIP original experiment: DIP-134647X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proceedings of the National Academy of Sciences of the United States of America 2009 imex curation Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. Only protein-protein interactions ecolx Escherichia coli ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Joerger AC., Rajagopalan S., Natan E., Veprintsev DB., Robinson CV., Fersht AR. DIP original experiment: DIP-134649X Proceedings of the National Academy of Sciences of the United States of America 2009 IMEx Structural evolution of p53, p63, and p73: implication for heterotetramer formation. p73_human Tumor protein p73 TP73 P73 p53-like transcription factor p53-related protein protein protein human Homo sapiens Human MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH DIP protein O15350 original sequence version: 170 DIP protein O15350-1 original sequence version: 100 DIP protein O15350 original sequence version: 123 DIP protein O15350 original sequence version: 149 DIP protein O15350-1 original sequence version: 165 DIP protein O15350 original sequence version: 92 DIP protein O15350-1 original sequence version: 122 DIP protein O15350-1 original sequence version: 135 DIP protein O15350-1 original sequence version: 174 A467493C5D93EEE0 p63_human Tumor protein 63 TP63 KET P63 P73H P73L TP73L Transformation-related protein 63 Tumor protein p73-like p51 p40 Keratinocyte transcription factor KET Chronic ulcerative stomatitis protein protein protein human Homo sapiens Human MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE DIP protein Q9H3D4 original sequence version: 99 DIP protein Q9H3D4 original sequence version: 100 DIP protein Q9H3D4 original sequence version: 119 DIP protein Q9H3D4-1 original sequence version: 146 DIP protein Q9H3D4 original sequence version: 146 DIP protein Q9H3D4 original sequence version: 142 DIP protein Q9H3D4 original sequence version: 68 F66ECD45E87D9799 tp73-10 3 7 unspecified role unspecified role unspecified role unspecified role Tetramerization domain Region 351-383 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp73-11 6 7 unspecified role unspecified role unspecified role unspecified role Tetramerization domain Region 351-399 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp63-4 2 8 unspecified role unspecified role unspecified role unspecified role Tetramerization domain Region 356-411 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp73-4 5 7 unspecified role unspecified role unspecified role unspecified role Tetramerization domain Region 351-383 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp63-9 1 8 unspecified role unspecified role unspecified role unspecified role Tetramerization domain Region 359-388 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction tp63-tp73-1 4 7 unspecified role unspecified role unspecified role unspecified role Tetramerization domain Region 351-399 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 8 unspecified role unspecified role unspecified role unspecified role Tetramerization domain Region 356-411 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction