DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nature structural & molecular biology 2009 imex curation Price AJ., Marzetta F., Lammers M., Ylinen LM., Schaller T., Wilson SJ., Towers GJ., James LC. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Price AJ., Marzetta F., Lammers M., Ylinen LM., Schaller T., Wilson SJ., Towers GJ., James LC. DIP original experiment: DIP-133310X Nature structural & molecular biology 2009 IMEx Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nature structural & molecular biology 2009 imex curation Price AJ., Marzetta F., Lammers M., Ylinen LM., Schaller T., Wilson SJ., Towers GJ., James LC. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Price AJ., Marzetta F., Lammers M., Ylinen LM., Schaller T., Wilson SJ., Towers GJ., James LC. DIP original experiment: DIP-133309X Nature structural & molecular biology 2009 IMEx Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. q76929_9hiv2 gag protein protein 9hiv2 Human immunodeficiency virus 2 ANELDRFGLAESLLESKEGCQRILTVLDPLVPTGSENLKSLFNTVCVAWCIHAEEKVKDTEGAKQIVQRHLVAETGTAEKMPSTSRPTAPPSGEGGNFPVQHVGGNYTHIPLSPRTLNAWVKLVEEKKFGAEVVPGFQALSEGCTPYDINQMLNCVGDHQAAMQIIREIINEEAAEWDVQHPIPGPLPAGQLREPRGSDIAGTTSTVDEQIQWMFRPQNPVPVGNIYRRWIQIGLQKCVRMYNPTNILDIKQGPKEPFQS DIP protein Q76929 original sequence version: 63 ppia_macmu Peptidyl-prolyl cis-trans isomerase A PPIA CYPA Cyclophilin A Cyclosporin A-binding protein Rotamase A protein protein macmu Macaca mulatta (Rhesus macaque) Rhesus macaque MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE DIP protein P62940 original sequence version: 52 q72497_9hiv1 Gag polyprotein gag protein protein 9hiv1 Human immunodeficiency virus 1 MGARASVLSGGELDKWEKIRLRPGGKKQYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTIAVLYCVHQRIDVKDTKEALDKIEEEQNKSKKKAQQAAADTGNNSQVSQNYPIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPGATLEEMMTACQGVGGPGHKARVLAEAMSQVTNPATIMIQKGNFRNQRKTVKCFNCGKEGHIAKNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSHKGRPGNFLQSRPEPTAPPEESFRFGEETTTPSQRQEPIDKELYPLASLRSLFGSDPSSQ DIP protein Q72497 original sequence version: 76 08F450AC834088C6 gag-ppia-9 2 3 unspecified role unspecified role unspecified role unspecified role Region 99-242 Region 99-242 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction gag-ppia-10 1 5 unspecified role unspecified role unspecified role unspecified role Region 133-278 Region 133-278 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction