<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="19506252" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0901249106" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15786705" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-14748" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2009</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Woodward OM.,  Köttgen A.,  Coresh J.,  Boerwinkle E.,  Guggino WB.,  Köttgen M.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-14748" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-134308X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="19506252" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0901249106" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="8355">
            <names>
              <shortLabel>xenla</shortLabel>
              <fullName>Xenopus laevis (African clawed frog)</fullName>
              <alias type="synonym" typeAc="MI:1041">African clawed frog</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>comig non denat gel</shortLabel>
            <fullName>comigration in non denaturing gel electrophoresis</fullName>
            <alias type="synonym" typeAc="MI:1041">comig non denat gel</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0404" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608489" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Woodward OM., Köttgen A., Coresh J., Boerwinkle E., Guggino WB., Köttgen M.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-134308X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2009</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>abcg2_human</shortLabel>
          <fullName>Broad substrate specificity ATP-binding cassette transporter ABCG2</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Placenta-specific ATP-binding cassette transporter</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Breast cancer resistance protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Mitoxantrone resistance-associated protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CDw338</alias>
          <alias type="gene name" typeAc="MI:0301">ABCG2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ABCP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">BCRP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">BCRP1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MXR</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Urate exporter</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ATP-binding cassette sub-family G member 2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UNQ0" version="SP_84" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A0A1W3" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O95374" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q53ZQ1" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q569L4" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5YLG4" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q86V64" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8IX16" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96LD6" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96TA8" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9BY73" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9NUS0" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q4W5I3" version="SP_141" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K1T5" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000237612" version="SP_209" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000498246" version="SP_209" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1569435" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004818.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011530722.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001244315.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005263412.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29162N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000118777" version="SP_209" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000237612" version="SP_209" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000650821" version="SP_209" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008514" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008559" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015143" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015225" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015562" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015711" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0015878" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016324" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031526" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031966" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032217" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032218" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042626" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042910" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046415" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0055085" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070633" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097744" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098591" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0140115" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0150104" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990748" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1990962" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003439" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003593" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013525" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR027417" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR030256" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043926" version="SP_209"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q9UNQ0" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5NJ3" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5NJG" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ETI" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FEQ" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6FFC" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6HBU" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6HCO" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6HIJ" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6HZM" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VXF" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VXH" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VXI" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VXJ" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7NEQ" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7NEZ" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7NFD" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-189451" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-189483" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2161517" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-917937" version="SP_209"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9UNQ0 original sequence version: 65</attribute>
          <attribute name="remark-internal">DIP protein Q9UNQ0 original sequence version: 111</attribute>
          <attribute name="remark-internal">DIP protein Q9UNQ0-1 original sequence version: 109</attribute>
          <attribute name="crc64">A8AF66B96034C5A8</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-14748-1">
        <names>
          <shortLabel>abcg2-3</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-57167E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15786724" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-14748-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="8355">
                <names>
                  <shortLabel>xenla</shortLabel>
                  <fullName>Xenopus laevis (African clawed frog)</fullName>
                  <alias type="synonym" typeAc="MI:1041">African clawed frog</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>