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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="19470455" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0811267106" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15783086" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-14770" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2009</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Wei S.,  Chen X.,  Rocha K.,  Epling-Burnette PK.,  Djeu JY.,  Liu Q.,  Byrd J.,  Sokol L.,  Lawrence N.,  Pireddu R.,  Dewald G.,  Williams A.,  Maciejewski J.,  List A.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-14770" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-134377X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="19470455" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0811267106" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human</shortLabel>
              <fullName>Homo sapiens</fullName>
              <alias type="synonym" typeAc="MI:1041">Human</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Wei S., Chen X., Rocha K., Epling-Burnette PK., Djeu JY., Liu Q., Byrd J., Sokol L., Lawrence N., Pireddu R., Dewald G., Williams A., Maciejewski J., List A.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-134377X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2009</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>mpip3_human</shortLabel>
          <fullName>M-phase inducer phosphatase 3</fullName>
          <alias type="gene name" typeAc="MI:0301">CDC25C</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Dual specificity phosphatase Cdc25C</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P30307" version="SP_89" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000321656" version="SP_209" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000424795" version="SP_209" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96PL3" version="SP_89" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H168" version="SP_89" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H2E8" version="SP_89" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H2E9" version="SP_89" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H2F1" version="SP_89" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DQB8" version="SP_116" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-974439" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000158402" version="SP_209" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000323760" version="SP_209" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000513970" version="SP_209" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000079" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004721" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004725" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005758" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007088" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007283" version="SP_209"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016607" version="SP_209"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050699" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0110032" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000751" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001763" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036873" version="SP_209"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P30307" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OJX" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3BZI" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OP3" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M35" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M36" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5M37" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-156711" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-176187" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5625740" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6804114" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6804115" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69273" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75035" version="SP_209"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8862803" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000086" version="SP_209"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001781.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_073720.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001305027.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011542064.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001274511.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-24183N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P30307 original sequence version: 148</attribute>
          <attribute name="remark-internal">DIP protein P30307 original sequence version: 88</attribute>
          <attribute name="remark-internal">DIP protein P30307 original sequence version: 112</attribute>
          <attribute name="remark-internal">DIP protein P30307 original sequence version: 108</attribute>
          <attribute name="crc64">0658A1F1B9B8996A</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>1433b_human</shortLabel>
          <fullName>14-3-3 protein beta/alpha</fullName>
          <alias type="gene name" typeAc="MI:0301">YWHAB</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protein kinase C inhibitor protein 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protein 1054</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P31946" version="SP_94" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K9K2" version="SP_112" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E1P616" version="SP_127" refType="secondary-ac" refTypeAc="MI:0360"/>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000361930" version="SP_235" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-359815" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003395.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_647539.1"/>
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          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-743N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P31946 original sequence version: 171</attribute>
          <attribute name="remark-internal">DIP protein P31946 original sequence version: 97</attribute>
          <attribute name="remark-internal">DIP protein P31946 original sequence version: 119</attribute>
          <attribute name="remark-internal">DIP protein P31946 original sequence version: 122</attribute>
          <attribute name="remark-internal">DIP protein P31946 original sequence version: 180</attribute>
          <attribute name="crc64">6BE1A9BF97468017</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-14770-1">
        <names>
          <shortLabel>cdc25c-ywhab-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-103983E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15783105" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-14770-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human</shortLabel>
                  <fullName>Homo sapiens</fullName>
                  <alias type="synonym" typeAc="MI:1041">Human</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human</shortLabel>
                  <fullName>Homo sapiens</fullName>
                  <alias type="synonym" typeAc="MI:1041">Human</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>