DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 imex curation Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. DIP original experiment: DIP-249887X Nature 2009 IMEx HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 imex curation Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. DIP original experiment: DIP-249889X Nature 2009 IMEx HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 imex curation Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. DIP original experiment: DIP-249886X Nature 2009 IMEx HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 imex curation Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. DIP original experiment: DIP-249890X Nature 2009 IMEx HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009 imex curation Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Guan JS., Haggarty SJ., Giacometti E., Dannenberg JH., Joseph N., Gao J., Nieland TJ., Zhou Y., Wang X., Mazitschek R., Bradner JE., DePinho RA., Jaenisch R., Tsai LH. DIP original experiment: DIP-249888X Nature 2009 IMEx HDAC2 negatively regulates memory formation and synaptic plasticity. mta2_mouse Metastasis-associated protein MTA2 Mta2 Mta1l1 Metastasis-associated 1-like 1 protein protein mouse Mus musculus Mouse MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTLLNETDILNQYLDKEDCFFYSLVFDPVQKTLLADQGEIRVGCKFQAEIPDRLAEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLKTPTQLEGAARGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLTQNRGLGGIMVKRSYETMAGAGVPFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLMTVRPPVPLPASSHPASTNEPIVLED DIP protein Q9R190 original sequence version: 108 DIP protein Q9R190 original sequence version: 99 DIP protein Q9R190 original sequence version: 119 DIP protein Q9R190 original sequence version: 138 DIP protein Q9R190 original sequence version: 144 DIP protein Q9R190 original sequence version: 111 88996F779BA6F4D1 sin3a_mouse Paired amphipathic helix protein Sin3a Sin3a Kiaa4126 Transcriptional corepressor Sin3a Histone deacetylase complex subunit Sin3a protein protein mouse Mus musculus Mouse MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAVSETMQSATGIQYSVAPNYQVSAVPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSSQSAPTPAQPAPQPTAAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHSGTGATPPVKKKPKLMSLKESSMADASKHGVGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLESFPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAPKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQVTDLYLAENNNGATGGQLNSQTSRSLLESAYQRKAEQLMSDENCFKLMFIQSQGQVQLTVELLDTEEENSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP DIP protein Q60520 original sequence version: 144 DIP protein Q60520 original sequence version: 106 DIP protein Q60520 original sequence version: 115 DIP protein Q60520 original sequence version: 158 80FE378F62ED7CB3 hdac1_mouse Histone deacetylase 1 Hdac1 protein protein mouse Mus musculus Mouse MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA DIP protein O09106 original sequence version: 147 DIP protein O09106 original sequence version: 87 DIP protein O09106 original sequence version: 131 DIP protein O09106 original sequence version: 119 DIP protein O09106 original sequence version: 106 DIP protein O09106 original sequence version: 144 DIP protein O09106 original sequence version: 146 DIP protein O09106 original sequence version: 161 DIP protein O09106 original sequence version: 167 DIP protein O09106 original sequence version: 169 DIP protein O09106 original sequence version: 124 DIP protein O09106 original sequence version: 134 DIP protein O09106 original sequence version: 103 DIP protein O09106 original sequence version: 122 7F64D3C17F5E4844 hdac2_mouse Histone deacetylase 2 Hdac2 Yy1bp YY1 transcription factor-binding protein protein protein mouse Mus musculus Mouse MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVAKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDPKGAKSEQLSNP DIP protein P70288 original sequence version: 83 DIP protein P70288 original sequence version: 123 DIP protein P70288 original sequence version: 112 DIP protein P70288 original sequence version: 99 DIP protein P70288 original sequence version: 155 DIP protein P70288 original sequence version: 117 B9843D24A775157C rcor2_mouse REST corepressor 2 Rcor2 M-CoREST protein protein mouse Mus musculus Mouse MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKVIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGAVSEGEPDTGDPKREPLPSRPLNARPGPGKKEVQISQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPAAPVPTEEARRGAPVPATALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPTLVGAPLEPPAPSL DIP protein Q8C796 original sequence version: 93 46A563C1CC11A7E4 hdac2-hdac1-1 3 7 unspecified role unspecified role prey prey mouse Mus musculus Mouse 6 unspecified role unspecified role prey prey mouse Mus musculus Mouse 10 unspecified role unspecified role prey prey mouse Mus musculus Mouse 9 unspecified role unspecified role bait bait mouse Mus musculus Mouse 8 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association rcor2-hdac2-1 5 10 unspecified role unspecified role bait bait mouse Mus musculus Mouse 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association mta2-hdac1-7 4 6 unspecified role unspecified role bait bait mouse Mus musculus Mouse 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse 8 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association sin3a-hdac1-4 2 7 unspecified role unspecified role bait bait mouse Mus musculus Mouse 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse 8 unspecified role unspecified role prey prey mouse Mus musculus Mouse association association hdac1-hdac2-9 1 7 unspecified role unspecified role prey prey mouse Mus musculus Mouse 6 unspecified role unspecified role prey prey mouse Mus musculus Mouse 9 unspecified role unspecified role prey prey mouse Mus musculus Mouse 8 unspecified role unspecified role bait bait mouse Mus musculus Mouse association association