<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Visualisation and quantification of morphogen gradient formation in the zebrafish.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="19419239" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1371/journal.pbio.1000101" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15779186" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-14156" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Visualisation and quantification of morphogen gradient formation in the zebrafish.</attribute>
            <attribute name="journal" nameAc="MI:0885">PLoS biology</attribute>
            <attribute name="publication year" nameAc="MI:0886">2009</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Harvey SA.,  Smith JC.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-14156" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-132615X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="19419239" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1371/journal.pbio.1000101" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="7955">
            <names>
              <shortLabel>danre</shortLabel>
              <fullName>Danio rerio (Zebrafish)</fullName>
              <alias type="synonym" typeAc="MI:1041">Brachydanio rerio</alias>
              <alias type="synonym" typeAc="MI:1041">Zebrafish</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>bifc</shortLabel>
            <fullName>bimolecular fluorescence complementation</fullName>
            <alias type="synonym" typeAc="MI:1041">bifc</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0809" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218483" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="11983170" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Harvey SA., Smith JC.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-132615X</attribute>
          <attribute name="journal" nameAc="MI:0885">PLoS biology</attribute>
          <attribute name="publication year" nameAc="MI:0886">2009</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Visualisation and quantification of morphogen gradient formation in the zebrafish.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>q9i9p4_danre</shortLabel>
          <alias type="gene name" typeAc="MI:0301">smad4a</alias>
          <alias type="gene name synonym" typeAc="MI:0302">madh4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">smad4</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9I9P4" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15779251" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000978" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007519" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009653" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030509" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043565" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048264" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0048738" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060026" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060395" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070411" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071141" version="TrEMBL_109"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071144" version="TrEMBL_109"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001132" version="TrEMBL_109"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008984" version="TrEMBL_109"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013790" version="TrEMBL_109"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017855" version="TrEMBL_109"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-48410N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="7955">
          <names>
            <shortLabel>danre</shortLabel>
            <fullName>Danio rerio (Zebrafish)</fullName>
            <alias type="synonym" typeAc="MI:1041">Brachydanio rerio</alias>
            <alias type="synonym" typeAc="MI:1041">Zebrafish</alias>
          </names>
        </organism>
        <sequence>MMVKDEYDYDGPPSLPSTEGHMQTIQHPPSRAVTQEPFSTPACSRSRRQQLPPPAPPSPASPSDPQIPPPPGAGTVTSPPSVPHHQNGHLQHHPPMAHPAHYWPVHNEIAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFCQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAFAQAAAVAGNIPDPGSVGGIVPAISLSAAAGIGGDDLRRLCILRMSFVKGWGPDYPRQSIKDTPCWIEIHLHRALQLLDEVLHTMPIADPTPLD</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9I9P4 original sequence version: null</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>smad2_danre</shortLabel>
          <fullName>Mothers against decapentaplegic homolog 2</fullName>
          <alias type="gene name" typeAc="MI:0301">smad2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">madh2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SMAD family member 2</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9I9P9" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDARP00000044755" version="SP_148" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDARP00000111803" version="SP_148" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDARP00000145128" version="SP_148" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q4V964" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9PUN4" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15779205" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-1181150" version="SP_148"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-1502540" version="SP_148"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-2173788" version="SP_148"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-2173789" version="SP_148"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-2173795" version="SP_148"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-2173796" version="SP_148"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-5689880" version="SP_148"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-DRE-9617828" version="SP_148"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036578" version="SP_148"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDARG00000006389" version="SP_148" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDART00000044756" version="SP_148" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDART00000128579" version="SP_148" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSDART00000184617" version="SP_148" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000978" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003700" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009653" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009880" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0021999" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030509" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0038092" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043565" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060282" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060395" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070411" version="SP_148"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071144" version="SP_148"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001132" version="SP_148"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003619" version="SP_148"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008984" version="SP_148"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013019" version="SP_148"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013790" version="SP_148"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017855" version="SP_148"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001276944.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_571441.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-41211N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="7955">
          <names>
            <shortLabel>danre</shortLabel>
            <fullName>Danio rerio (Zebrafish)</fullName>
            <alias type="synonym" typeAc="MI:1041">Brachydanio rerio</alias>
            <alias type="synonym" typeAc="MI:1041">Zebrafish</alias>
          </names>
        </organism>
        <sequence>MSSILPFTPPVVKRLLGWKKSASGSSGAGGGGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNRNTKCVTIPSNCSEIWGLSTPNTIEQWDTSGLYSYPDQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAIETCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTNSIPENTNFPTGIEPPNNYIPETPPPGYISEDGEASDQQMNQSMDTGSPAELSPSTLSPVNHGMDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q9I9P9 original sequence version: null</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-14156-1">
        <names>
          <shortLabel>smad2-smad4a-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-102837E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15779272" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-14156-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="7955">
                <names>
                  <shortLabel>danre</shortLabel>
                  <fullName>Danio rerio (Zebrafish)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Brachydanio rerio</alias>
                  <alias type="synonym" typeAc="MI:1041">Zebrafish</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="7955">
                <names>
                  <shortLabel>danre</shortLabel>
                  <fullName>Danio rerio (Zebrafish)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Brachydanio rerio</alias>
                  <alias type="synonym" typeAc="MI:1041">Zebrafish</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>