DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133028X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133036X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133029X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133030X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133034X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133031X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133035X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133033X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nature structural & molecular biology 2009 imex curation Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Patenaude AM., Orthwein A., Hu Y., Campo VA., Kavli B., Buschiazzo A., Di Noia JM. DIP original experiment: DIP-133032X Nature structural & molecular biology 2009 IMEx Active nuclear import and cytoplasmic retention of activation-induced deaminase. xpo1_human Exportin-1 CRM1 XPO1 Chromosome region maintenance 1 protein homolog protein protein human Homo sapiens Human MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTSLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD DIP protein O14980 original sequence version: 98 DIP protein O14980 original sequence version: 120 DIP protein O14980 original sequence version: 97 DIP protein O14980 original sequence version: 96 DIP protein O14980 original sequence version: 116 DIP protein O14980 original sequence version: 129 DIP protein O14980 original sequence version: 130 FDB00C065DA2FB1D ima6_human Importin subunit alpha-6 Karyopherin subunit alpha-5 KPNA5 protein protein human Homo sapiens Human MASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL DIP protein O15131 original sequence version: 94 757D4C56D0E5661F aicda_human Single-stranded DNA cytosine deaminase AICDA AID Cytidine aminohydrolase Activation-induced cytidine deaminase protein protein human Homo sapiens Human MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL DIP protein Q9GZX7 original sequence version: 123 DIP protein Q9GZX7 original sequence version: 82 3C27BB143DB184A9 ima4_human Importin subunit alpha-4 KPNA3 QIP2 Karyopherin subunit alpha-3 SRP1-gamma Importin alpha Q2 protein protein human Homo sapiens Human MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF DIP protein O00505 original sequence version: 107 C4FF132C3F346B7F ima5_human Importin subunit alpha-5 KPNA1 RCH2 Karyopherin subunit alpha-1 SRP1-beta RAG cohort protein 2 Nucleoprotein interactor 1 protein protein human Homo sapiens Human MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL DIP protein P52294 original sequence version: 72 DIP protein P52294 original sequence version: 90 DIP protein P52294 original sequence version: 112 DIP protein P52294 original sequence version: 160 E8407A3352D6051C aicda-aicda-1 1 12 unspecified role unspecified role prey prey Q9GZX7:p.[Phe46Ala;Tyr48Ala;Arg50Gly;Asn51Ala] F46A/Y48A/R50G/N51A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain R G certain certain sequence position certain certain certain sequence position certain Y A certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F46A/Y48A/R50G/N51A'. Wed May 02 17:34:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe46ala,tyr48ala,arg50gly,asn51ala' Tue Jun 30 15:37:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Phe46Ala;Tyr48Ala;Arg50Gly;Asn51Ala]' GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 12 unspecified role unspecified role bait bait Q9GZX7:p.[Phe46Ala;Tyr48Ala;Arg50Gly;Asn51Ala] F46A/Y48A/R50G/N51A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain R G certain certain sequence position certain certain certain sequence position certain Y A certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F46A/Y48A/R50G/N51A'. Wed May 02 16:54:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe46ala,tyr48ala,arg50gly,asn51ala' Tue Jun 30 18:31:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Phe46Ala;Tyr48Ala;Arg50Gly;Asn51Ala]' Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association aicda-xpo1-1 4 10 unspecified role unspecified role prey prey human Homo sapiens Human 12 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q9GZX7:p.Leu198Ser L198S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain L S This feature has been corrected as a result of our quality control procedures. The original label was 'L198S'. Wed May 02 19:16:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu198ser' Tue Jun 30 16:48:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu198Ser' Q9GZX7:p.[Leu196Ser;Leu198Ser] L196S/L198S mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain L S certain certain sequence position certain certain certain sequence position certain L S This feature has been corrected as a result of our quality control procedures. The original label was 'L196S/L198S'. Wed May 02 15:42:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu196ser,leu198ser' Tue Jun 30 17:39:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Leu196Ser;Leu198Ser]' human Homo sapiens Human physical association physical association kpna5-aicda-1 2 11 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 12 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association kpna3-aicda-1 5 13 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 12 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association kpna1-aicda-1 9 14 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 12 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association aicda-aicda-2 3 12 unspecified role unspecified role prey prey GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 12 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association kpna1-aicda-2 6 14 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 12 unspecified role unspecified role prey prey GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association kpna5-aicda-2 7 11 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 12 unspecified role unspecified role prey prey GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association kpna3-aicda-2 8 13 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 12 unspecified role unspecified role prey prey GFP-tag GFP-tag gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q9GZX7:p.[Phe46Ala;Tyr48Ala;Arg50Gly;Asn51Ala] F46A/Y48A/R50G/N51A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain R G certain certain sequence position certain certain certain sequence position certain Y A certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F46A/Y48A/R50G/N51A'. Wed May 02 16:02:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe46ala,tyr48ala,arg50gly,asn51ala' Tue Jun 30 19:59:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Phe46Ala;Tyr48Ala;Arg50Gly;Asn51Ala]' Region 1-26 Region 1-26 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association