DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS biology 2009 imex curation Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. Only protein-protein interactions in vitro In vitro fps fluorescence polarization spectroscopy Fluorescence anisotropy FPS FPS Fluorescence anisotropy fps predetermined predetermined participant predetermined Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. DIP original experiment: DIP-132587X PLoS biology 2009 IMEx The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS biology 2009 imex curation Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. Only protein-protein interactions in vitro In vitro fps fluorescence polarization spectroscopy Fluorescence anisotropy FPS FPS Fluorescence anisotropy fps predetermined predetermined participant predetermined Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. DIP original experiment: DIP-132586X PLoS biology 2009 IMEx The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS biology 2009 imex curation Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. Only protein-protein interactions in vitro In vitro fps fluorescence polarization spectroscopy Fluorescence anisotropy FPS FPS Fluorescence anisotropy fps predetermined predetermined participant predetermined Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. DIP original experiment: DIP-132588X PLoS biology 2009 IMEx The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. PLoS biology 2009 imex curation Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. Only protein-protein interactions in vitro In vitro fps fluorescence polarization spectroscopy Fluorescence anisotropy FPS FPS Fluorescence anisotropy fps predetermined predetermined participant predetermined Pardee KI., Xu X., Reinking J., Schuetz A., Dong A., Liu S., Zhang R., Tiefenbach J., Lajoie G., Plotnikov AN., Botchkarev A., Krause HM., Edwards A. DIP original experiment: DIP-132589X PLoS biology 2009 IMEx The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. nr1d1_human Nuclear receptor subfamily 1 group D member 1 NR1D1 EAR1 HREV THRAL Rev-erbA-alpha V-erbA-related protein 1 protein protein human Homo sapiens Human MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ DIP protein P20393 original sequence version: 124 DIP protein P20393 original sequence version: 162 DIP protein P20393 original sequence version: 132 67C71758E166508A smrt SMRT peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ASTNMGLEAIIRKALMGKYD q6i9s1_human NR1D2 protein protein human Homo sapiens Human MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDINGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP DIP protein Q6I9S1 original sequence version: 44 ncor NCOR peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) DPASNLGLEDIIRKALMGSF ncor-nr1d2-1 3 7 unspecified role unspecified role unspecified role unspecified role Region 212-579 Region 212-579 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 8 unspecified role unspecified role unspecified role unspecified role Fluorescein-label Fluorescein-label fluorescent dye fluorescent dye label fluorescent dye n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal in vitro In vitro direct interaction direct interaction ncor-nr1d1-1 2 8 unspecified role unspecified role unspecified role unspecified role Fluorescein-label Fluorescein-label fluorescent dye fluorescent dye label fluorescent dye n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal in vitro In vitro 5 unspecified role unspecified role unspecified role unspecified role Region 274-323/423-614 Region 274-323/423-614 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction nr1d2-smrt-1 4 6 unspecified role unspecified role unspecified role unspecified role Fluorescein-label Fluorescein-label fluorescent dye fluorescent dye label fluorescent dye n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal in vitro In vitro 7 unspecified role unspecified role unspecified role unspecified role Region 212-579 Region 212-579 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction nr1d1-smrt-1 1 6 unspecified role unspecified role unspecified role unspecified role Fluorescein-label Fluorescein-label fluorescent dye fluorescent dye label fluorescent dye n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal in vitro In vitro 5 unspecified role unspecified role unspecified role unspecified role Region 274-323/423-614 Region 274-323/423-614 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction