DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Structure (London, England : 1993) 2008 imex curation Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132181X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Structure (London, England : 1993) 2008 imex curation Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132180X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Structure (London, England : 1993) 2008 imex curation Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132178X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Structure (London, England : 1993) 2008 imex curation Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Lin CC., Huoh YS., Schmitz KR., Jensen LE., Ferguson KM. DIP original experiment: DIP-132179X Structure (London, England : 1993) 2008 IMEx Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. peli2_human E3 ubiquitin-protein ligase pellino homolog 2 PELI2 RING-type E3 ubiquitin transferase pellino homolog 2 protein protein human Homo sapiens Human MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID DIP protein Q9HAT8 original sequence version: 60 2FC5E661C13BC11A peli1_mouse E3 ubiquitin-protein ligase pellino homolog 1 Peli1 RING-type E3 ubiquitin transferase pellino homolog 1 protein protein mouse Mus musculus Mouse MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERSPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD DIP protein Q8C669 original sequence version: 51 26072654577EBBF7 q8n2h9-2 E3 ubiquitin-protein ligase pellino homolog 3 PELI3 RING-type E3 ubiquitin transferase pellino homolog 3 B Beta protein protein human Homo sapiens Human MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD DIP protein Q8N2H9-2 original sequence version: 61 AD1D7E00533CD807 rad9 (pt192) Rad9 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) WSLEVTEADT irak1_human Interleukin-1 receptor-associated kinase 1 IRAK1 IRAK protein protein human Homo sapiens Human MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS DIP protein P51617 original sequence version: 141 DIP protein P51617 original sequence version: 84 DIP protein P51617 original sequence version: 85 DIP protein P51617-1 original sequence version: 103 DIP protein P51617-1 original sequence version: 108 DIP protein P51617 original sequence version: 113 DIP protein P51617 original sequence version: 123 A7ADED75D3A3981D peli1-irak1-3 3 9 unspecified role unspecified role prey prey Xpress-tag Xpress-tag tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 6 unspecified role unspecified role bait bait Region 2-287 Region 2-287 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli physical association physical association peli3-irak1-5 2 7 unspecified role unspecified role bait bait Region 2-313 Region 2-313 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli 9 unspecified role unspecified role prey prey Xpress-tag Xpress-tag tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association peli2-irak1-3 4 5 unspecified role unspecified role bait bait Region 15-275 Region 15-275 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Q9HAT8:p.Arg106Ala R106A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R106A'. Wed May 02 16:39:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg106ala' Tue Jun 30 19:07:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg106Ala' Q9HAT8:p.[Thr187Ala;Asn188Ala] T187A/N188A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N A certain certain sequence position certain certain certain sequence position certain T A This feature has been corrected as a result of our quality control procedures. The original label was 'T187A/N188A'. Wed May 02 18:38:52 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr187ala,asn188ala' Tue Jun 30 19:10:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Thr187Ala;Asn188Ala]' GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 9 unspecified role unspecified role prey prey Xpress-tag Xpress-tag tag tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association rad9 (pt192)-peli2-1 1 8 unspecified role unspecified role bait bait pT6 pT6 opthr O-phospho-L-threonine (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)butanoic acid MOD_RES Phosphothreonine O-phospho-L-threonine O-phosphorylated L-threonine O3-phosphothreonine threonine phosphate ester OPThr Phospho Phospho Threonyl Phosphorylation phosphorylationt certain certain sequence position certain certain certain sequence position certain in vitro In vitro 5 unspecified role unspecified role prey prey Q9HAT8:p.Arg106Ala R106A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R106A'. Wed May 02 17:49:39 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg106ala' Tue Jun 30 18:23:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Arg106Ala' ecolx Escherichia coli direct interaction direct interaction