DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A crystallographic snapshot of tyrosine trans-phosphorylation in action. A crystallographic snapshot of tyrosine trans-phosphorylation in action. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Chen H., Xu CF., Ma J., Eliseenkova AV., Li W., Pollock PM., Pitteloud N., Miller WT., Neubert TA., Mohammadi M. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Chen H., Xu CF., Ma J., Eliseenkova AV., Li W., Pollock PM., Pitteloud N., Miller WT., Neubert TA., Mohammadi M. DIP original experiment: DIP-133565X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx A crystallographic snapshot of tyrosine trans-phosphorylation in action. A crystallographic snapshot of tyrosine trans-phosphorylation in action. A crystallographic snapshot of tyrosine trans-phosphorylation in action. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Chen H., Xu CF., Ma J., Eliseenkova AV., Li W., Pollock PM., Pitteloud N., Miller WT., Neubert TA., Mohammadi M. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Chen H., Xu CF., Ma J., Eliseenkova AV., Li W., Pollock PM., Pitteloud N., Miller WT., Neubert TA., Mohammadi M. DIP original experiment: DIP-133566X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx A crystallographic snapshot of tyrosine trans-phosphorylation in action. p21802-1 Fibroblast growth factor receptor 2 K-sam Keratinocyte growth factor receptor BEK FGFR2IIIc FGFR2 BEK KGFR KSAM protein protein human Homo sapiens Human MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT DIP protein P21802-1 original sequence version: 205 DIP protein P21802-1 original sequence version: 149 DIP protein P21802 original sequence version: 163 DIP protein P21802-1 original sequence version: 189 DIP protein P21802 original sequence version: 189 DIP protein P21802-1 original sequence version: 186 fgfr2-fgfr2-2 1 3 enzyme enzyme unspecified role unspecified role Region 458-768 Region 458-768 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 3 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 458-778 Region 458-778 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain pY769 pY769 optyr O4'-phospho-L-tyrosine (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4-phosphotyrosine tyrosine phosphate 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine OPTyr Phospho Phospho Tyrosinyl Phosphorylation phosphorylationy certain certain sequence position certain certain certain sequence position certain P21802-1:p.Lys517Met K517M mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K M This feature has been corrected as a result of our quality control procedures. The original label was 'K517M'. Wed May 02 18:53:47 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys517met' Tue Jun 30 16:48:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys517Met' P21802-1:p.Phe600Ala F600A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F600A'. Wed May 02 20:31:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe600ala' Tue Jun 30 19:03:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe600Ala' P21802-1:p.Leu770Ala L770A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain L A This feature has been corrected as a result of our quality control procedures. The original label was 'L770A'. Wed May 02 15:06:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu770ala' Tue Jun 30 17:41:24 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu770Ala' P21802-1:p.Asn730Ala N730A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N A This feature has been corrected as a result of our quality control procedures. The original label was 'N730A'. Wed May 02 16:27:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn730ala' Tue Jun 30 16:30:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn730Ala' P21802-1:p.Asn766Ala N766A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain N A This feature has been corrected as a result of our quality control procedures. The original label was 'N766A'. Wed May 02 15:50:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn766ala' Tue Jun 30 20:10:41 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn766Ala' P21802-1:p.Glu767Ala E767A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain E A This feature has been corrected as a result of our quality control procedures. The original label was 'E767A'. Wed May 02 19:24:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu767ala' Tue Jun 30 17:53:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu767Ala' P21802-1:p.Asp771Ala D771A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D771A'. Wed May 02 15:50:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp771ala' Tue Jun 30 18:56:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp771Ala' P21802-1:p.Leu772Ala L772A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain L A This feature has been corrected as a result of our quality control procedures. The original label was 'L772A'. Wed May 02 16:14:57 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu772ala' Tue Jun 30 17:19:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu772Ala' ecolx Escherichia coli phosphorylation phosphorylation reaction phosphorylation fgfr2-fgfr2-3 2 3 unspecified role unspecified role unspecified role unspecified role Region 764-778 Region 764-778 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 3 unspecified role unspecified role unspecified role unspecified role Region 458-778 Region 458-778 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction