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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="18845684" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0806222105" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15732780" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-14341" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Niizuma K.,  Endo H.,  Nito C.,  Myer DJ.,  Kim GS.,  Chan PH.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-14341" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-133405X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="18845684" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0806222105" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="10116">
            <names>
              <shortLabel>rat</shortLabel>
              <fullName>Rattus norvegicus (Rat)</fullName>
              <alias type="synonym" typeAc="MI:1041">Rat</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Niizuma K., Endo H., Nito C., Myer DJ., Kim GS., Chan PH.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-133405X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.</attribute>
        </attributeList>
      </experimentDescription>
      <experimentDescription id="2">
        <names>
          <fullName>The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="18845684" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0806222105" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15732780" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-14341" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Niizuma K.,  Endo H.,  Nito C.,  Myer DJ.,  Kim GS.,  Chan PH.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-14341" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-133404X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="18845684" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0806222105" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="10116">
            <names>
              <shortLabel>rat</shortLabel>
              <fullName>Rattus norvegicus (Rat)</fullName>
              <alias type="synonym" typeAc="MI:1041">Rat</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Niizuma K., Endo H., Nito C., Myer DJ., Kim GS., Chan PH.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-133404X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>d3zb14_rat</shortLabel>
          <alias type="gene name" typeAc="MI:0301">Cradd</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cradd_predicted</alias>
          <alias type="orf name" typeAc="MI:0306">rCG_48999</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="D3ZB14" version="4" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000062865" version="TrEMBL_79" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15732828" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000008507" version="TrEMBL_79" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000063946" version="TrEMBL_79" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002020" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006977" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030674" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0070513" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071260" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097190" version="TrEMBL_79"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001235" version="TrEMBL_79"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001315" version="TrEMBL_79"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011029" version="TrEMBL_79"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037939" version="TrEMBL_79"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR042148" version="TrEMBL_79"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-6803207" version="TrEMBL_79"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="1311010"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001101555.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-48601N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MDARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEIKAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLEKAREEATAELPTAQPRKDHLPEKPFIIRLITAAPREAAPESLSPVAETAQSGQKGRLDQSNSCPSAPVAATEACLDQS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein D3ZB14 original sequence version: 4</attribute>
        </attributeList>
      </interactor>
      <interactor id="4">
        <names>
          <shortLabel>d3zzy5_rat</shortLabel>
          <alias type="gene name" typeAc="MI:0301">Pidd1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">LOC100911519</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="D3ZZY5" version="4" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000025291" version="TrEMBL_97" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000065320" version="TrEMBL_97" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15732799" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000018710" version="TrEMBL_97" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000049179" version="TrEMBL_97" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000025290" version="TrEMBL_97" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000072774" version="TrEMBL_97" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004175" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006974" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006977" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008625" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016540" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043122" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097190" version="TrEMBL_97"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097191" version="TrEMBL_97"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000488" version="TrEMBL_97"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000906" version="TrEMBL_97"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001611" version="TrEMBL_97"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003591" version="TrEMBL_97"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011029" version="TrEMBL_97"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019502" version="TrEMBL_97"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032675" version="TrEMBL_97"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-6803207" version="TrEMBL_97"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001099788.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_003749059.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_008772966.1"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="1311792"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="6492303"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-48600N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MAAVLEGPKPEETAAAAEDAARPTVEAVASRPGVPILLAGNQLNLDLRPGGCRRLQYLCSQQHTQLLQVEFLRLSTHEDPRLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACLHGTLTTLPASMRDLACLAHLDLSFNRLETLPTCVLELHSLDALLLSHNCLSELPEALGALPTLTFLTVTHNLLERLPPTLGSLSTLQRLDLSENLLDTIPSEIGDLSSLRELNLASNRLQHLPASLAGLRSLRLLVLHSNLLTSVPPGLAHLPLITRLDLRDNQLRDLPAELLDAPFVRLQGNPLGEASPAPPSPPDISQVPEMPRLFLTSDLDSFLVTPHGCSVTLACGVRLQFPAGATTTPITIHYRLWLPEPGLVSLGPHDFLLSGVLELQPHGVAFQQNVSLWLLFVPPRVRVRRCREVVVRTRSDNIWNDLETHLEEEAPKRRWARCQVPHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLSQSGPPSFLQPVTVQLPLPPGVTGFSLDRSHLHLLYRTPLTSTWDDISTQVALEFTHLYARFQVTHFSWYWLWYTTKTCVGGLARKAWERLRLHRVNLIALQRRRDPEQVLLQCLPRSKVDATLSRLLDRYRGPEPSETVEMFEGEKFFAAFERGIDVDADRPDCVDGRICFVFYSHLKNMKEVYITTALDREAQDVRGQVSFYRGSLPMEVPEEAEAARRRKGTDALWMATLPIKLPRLRGAQGSGQGTDFSLMPLNLGDAETGFLTQSNLLSVASRLGSDWPTVALHLGMPYRKLQRIRHEFRDDLDGQIRHMLFSWAESQTGQPGAVGHLVQALEQSDRQDVAEEVRAILELGRHKYQDSIRRTGLAPEDSTLPSTSALQNPESAQA</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein D3ZZY5 original sequence version: 4</attribute>
        </attributeList>
      </interactor>
      <interactor id="5">
        <names>
          <shortLabel>casp2_rat</shortLabel>
          <fullName>Caspase-2</fullName>
          <alias type="gene name" typeAc="MI:0301">Casp2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Ich1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protease ICH-1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P55215" version="93" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOP00000022672" version="SP_178" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O35398" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O55194" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9WUI6" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15732853" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOG00000016707" version="SP_178" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSRNOT00000022672" version="SP_178" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001554" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003407" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004197" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006508" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006977" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007420" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007568" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008630" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0012501" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016485" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035234" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043525" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0071260" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097153" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097190" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097192" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097199" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097200" version="SP_178"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2001235" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001309" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001315" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002398" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011029" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015917" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016129" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029030" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033139" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035702" version="SP_178"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-168638" version="SP_178"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-205025" version="SP_178"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-RNO-6803207" version="SP_178"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002138" version="SP_178"/>
          <secondaryRef db="rgd" dbAc="MI:0483" id="69274"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_071967.2"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-48602N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10116">
          <names>
            <shortLabel>rat</shortLabel>
            <fullName>Rattus norvegicus (Rat)</fullName>
            <alias type="synonym" typeAc="MI:1041">Rat</alias>
          </names>
        </organism>
        <sequence>MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDTMEHSLDNGDGPPCLQVKPCTPEFYQAHYQLAYRLQSQPRGLALVMSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P55215 original sequence version: 93</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="6" imexId="IM-14341-1">
        <names>
          <shortLabel>pidd1-casp2-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-103272E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15732900" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-14341-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>2</experimentRef>
        </experimentList>
        <participantList>
          <participant id="7">
            <interactorRef>5</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="8">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="9">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
      <interaction id="10" imexId="IM-14341-2">
        <names>
          <shortLabel>casp2-cradd-9</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-103272E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15732918" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-14341-2" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="11">
            <interactorRef>5</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="12">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="13">
            <interactorRef>4</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="10116">
                <names>
                  <shortLabel>rat</shortLabel>
                  <fullName>Rattus norvegicus (Rat)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Rat</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>association</shortLabel>
            <fullName>association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>