DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. DIP original experiment: DIP-113323X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx f.3 Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. DIP original experiment: DIP-113325X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. DIP original experiment: DIP-113326X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx f.4 Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. DIP original experiment: DIP-113324X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Lejmi E., Leconte L., Pédron-Mazoyer S., Ropert S., Raoul W., Lavalette S., Bouras I., Feron JG., Maitre-Boube M., Assayag F., Feumi C., Alemany M., Jie TX., Merkulova T., Poupon MF., Ruchoux MM., Tobelem G., Sennlaub F., Plouët J. DIP original experiment: DIP-113327X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. unc5b_human Netrin receptor UNC5B UNC5B P53RDL1 UNC5H2 Protein unc-5 homolog 2 Protein unc-5 homolog B p53-regulated receptor for death and life protein 1 UNQ1883/PRO4326 protein protein human Homo sapiens Human MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSLKVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC DIP protein Q8IZJ1 original sequence version: 55 56064E335F323447 unc5c_human Netrin receptor UNC5C UNC5C Protein unc-5 homolog 3 Protein unc-5 homolog C UNC5H3 protein protein human Homo sapiens Human MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY DIP protein O95185 original sequence version: 67 98A95995129532A7 neo1_human Neogenin NEO1 IGDCC2 NGN Immunoglobulin superfamily DCC subclass member 2 protein protein human Homo sapiens Human MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA DIP protein Q92859 original sequence version: 89 4AADF1EEBCAFD82C net4_human Netrin-4 Beta-netrin Hepar-derived netrin-like protein NTN4 protein protein human Homo sapiens Human MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK DIP protein Q9HB63 original sequence version: 49 DIP protein Q9HB63 original sequence version: 68 275613B63A39B267 net1_human Netrin-1 NTN1 NTN1L Epididymis tissue protein Li 131P protein protein human Homo sapiens Human MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA DIP protein O95631 original sequence version: 69 DIP protein O95631 original sequence version: 86 9827C09D0D783B27 neo1-ntn4-1 1 9 unspecified role unspecified role prey prey unknown Unknown 8 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association unc5b-neo1-1 3 8 unspecified role unspecified role prey prey human Homo sapiens Human 6 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association unc5b-ntn1-6 4 10 unspecified role unspecified role prey prey unknown Unknown 6 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association neo1-ntn1-1 5 10 unspecified role unspecified role prey prey unknown Unknown 8 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association unc5c-ntn1-1 2 10 unspecified role unspecified role prey prey unknown Unknown 7 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association