DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS biology 2008 imex curation Komatsu H., Chao MY., Larkins-Ford J., Corkins ME., Somers GA., Tucey T., Dionne HM., White JQ., Wani K., Boxem M., Hart AC. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Komatsu H., Chao MY., Larkins-Ford J., Corkins ME., Somers GA., Tucey T., Dionne HM., White JQ., Wani K., Boxem M., Hart AC. DIP original experiment: DIP-110860X PLoS biology 2008 IMEx OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS biology 2008 imex curation Komatsu H., Chao MY., Larkins-Ford J., Corkins ME., Somers GA., Tucey T., Dionne HM., White JQ., Wani K., Boxem M., Hart AC. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Komatsu H., Chao MY., Larkins-Ford J., Corkins ME., Somers GA., Tucey T., Dionne HM., White JQ., Wani K., Boxem M., Hart AC. DIP original experiment: DIP-110859X PLoS biology 2008 IMEx OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. PLoS biology 2008 imex curation Komatsu H., Chao MY., Larkins-Ford J., Corkins ME., Somers GA., Tucey T., Dionne HM., White JQ., Wani K., Boxem M., Hart AC. Only protein-protein interactions yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Komatsu H., Chao MY., Larkins-Ford J., Corkins ME., Somers GA., Tucey T., Dionne HM., White JQ., Wani K., Boxem M., Hart AC. DIP original experiment: DIP-110858X PLoS biology 2008 IMEx OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development. lin12_caeel Protein lin-12 lin-12 Abnormal cell lineage protein 12 Notch-like protein lin-12 R107.8 protein protein caeel Caenorhabditis elegans MRIPTICFLFLLISLSKSLHIGSCLGLICGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCACPDGFKGERCELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSHGVCISFSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIPDICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKECPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGFCVCPPDFTGNQCEVNRKNGKSSLSENLCLSDPCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVCINEEEKGRKCECSYGFSGARCEEKINLTGFTEKDSLLRSVCEKRKCSERANDGNCDADCNYAACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVVRCPVKIREHCASRFANGICDPECNTNGCGFDGGDCDNETNATIITNIRITVQMDPKEFQVTGGQSLMEISSALRVTVRIQRDEEGPLVFQWNGESEMDRVKMNERQLTEQHVLSTSISRKIKRSATNIGVVVYLEVQENCDTGKCLYKDAQSVVDSISARLAKKGIDSFGIPISEALVAEPRKSGNNTGFLSWNALLLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWMPPMENEEKNRKNHQSITSSQHSLLEASYDGYIKRQRNELQHYSLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIKLHTEAAGSYAITEPITRESVNIIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIAAGADVNAMDCDENTPLMLAVLARRRRLVAYLMKAGADPTIYNKSERSALHQAAANRDFGMMVYMLNSTKLKGDIEELDRNGMTALMIVAHNEGRDQVASAKLLVEKGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDEDGKTPIMLAAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDRCRPEREYSMDLHIQHTHQPQPSRKVTRAPKKQTSRSKKESASNSRDSTHLTPPPSDGSTSTPSPQHFMNTTHTTPTSLNYLSPEYQTEAGSSEAFQPQCGAFGNGEMWYTRASTSYTQMQNEPMTRYSEPAHYF DIP protein P14585 original sequence version: 96 255EDD7A62C025DB osm11_caeel Notch ligand osm-11 osm-11 Osmotic avoidance abnormal protein 11 F11C7.5 protein protein caeel Caenorhabditis elegans MNFITVAALAIVMVLAQANPARVRRNEEMSERYCIKHLDHYNKYCGDNAGPIDRALFGKVAKFCPAYEKHCAVGKAGLVELPDLGSPLVMPPVLPRGSDFASLDLPIADERKPAHIHSSRTAPQTTRLTAAIVATCTPECTAAHCTDECKCAHTHPKVHQMCNPPSSAAMAETCQRWYSKCTMFTPVQY DIP protein O45346 original sequence version: 35 5E1161004C597334 lag2_caeel Protein lag-2 lag-2 let-461 Y73C8B.4 Lethal protein 461 protein protein caeel Caenorhabditis elegans MIAYFLLLLTCLPVLQARVEVHQEFISSKRVSVRFEIVTESHSPNRPVTFDLFPRGPKTNIILLDTFNPVFNFSIQLVQPFTGQPLGDRIYRKVQFSGTNQPWINDTFTTTSGISLSVATEVTCARNYFGNRCENFCDAHLAKAARKRCDAMGRLRCDIGWMGPHCGQAVDPRKCSCENDGICVSSMIHPSQPNQTSSNEQLICECTNGFTGTRCEIFGFNQFQLTAPRPDACSVKDACLNGAKCFPNGPKVFCSCAVGFIGEFCEISLTTTTPTTVEITVSTSGYSSAVYITVALFVIFSIIIGCFKYKFKPMRQQALARGQVPEPYKMPETKSMLIDPEASEAQKKVFTIEGSVQKIDEEVRYTSAPRKYESNNEYAVIQKSTPPPPSLSPPSIPACHYV DIP protein P45442 original sequence version: 61 dsl1_caeel Delta-like protein dsl-1 DSL-domain containing protein dsl-1 W09G12.4 dsl-1 protein protein caeel Caenorhabditis elegans MLKYLIFLAILISVVHSNGYMTIRLKSAFPLNVTVEVAEEVYFPTNKRSFNLQLKPNRVGFVSNIPVKFGRPGLVLVDCSPVEKFQIHRVTLRSIRWNTHVRSVASDNIFLPFTGFRYDIKCNRYWHGLHCDHFCNDDFARTINRRCTQNGTLGCLEGFHGPNCELPVPADSCKCQNGGKCVSSLENTWAQNGSLICECRLGHFEGKHCEKKSFNYFPKIEATTYATKDSHLARQFYNNSRVPNELATLPRL DIP protein O45201 original sequence version: 57 osm_11-lin_12-1 3 4 unspecified role unspecified role prey prey Region 20-323 Region 20-323 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 5 unspecified role unspecified role bait bait yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast direct interaction direct interaction dsl_1-lin_12-1 2 7 unspecified role unspecified role bait bait yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 4 unspecified role unspecified role prey prey Region 20-323 Region 20-323 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast direct interaction direct interaction lag_2-lin_12-1 1 6 unspecified role unspecified role bait bait Region 16-279 Region 16-279 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 4 unspecified role unspecified role prey prey Region 20-323 Region 20-323 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast direct interaction direct interaction