DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111285X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111284X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111283X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111281X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111282X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111286X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111288X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liu X., Fitzgerald K., Kurt-Jones E., Finberg R., Knipe DM. DIP original experiment: DIP-111287X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. itp_hhv11 Inner tegument protein UL37 Viral deamidase UL37 protein protein hhv11 Human herpesvirus 1 (strain 17) (HHV-1) Human herpes simplex virus 1 HHV-1 MADRGLPSEAPVVTTSPAGPPSDGPMQRLLASLAGLRQPPTPTAETANGADDPAFLATAKLRAAMAAFLLSGTAIAPADARDCWRPLLEHLCALHRAHGLPETALLAENLPGLLVHRLVVALPEAPDQAFREMEVIKDTILAVTGSDTSHALDSAGLRTAAALGPVRVRQCAVEWIDRWQTVTKSCLAMSPRTSIEALGETSLKMAPVPLGQPSANLTTPAYSLLFPAPFVQEGLRFLALVSNRVTLFSAHLQRIDDATLTPLTRALFTLALVDEYLTTPERGAVVPPPLLAQFQHTVREIDPAIMIPPLEANKMVRSREEVRVSTALSRVSPRSACAPPGTLMARVRTDVAVFDPDVPFLSSSALAVFQPAVSSLLQLGEQPSAGAQQRLLALLQQTWTLIQNTNSPSVVINTLIDAGFTPSHCTHYLSALEGFLAAGVPARTPTGHGLGEVQQLFGCIALAGSNVFGLAREYGYYANYVKTFRRVQGASEHTHGRLCEAVGLSGGVLSQTLARIMGPAVPTEHLASLRRALVGEFETAERRFSSGQPSLLRETALIWIDVYGQTHWDITPTTPATPLSALLPVGQPSHAPSVHLAAATQIRFPALEGIHPNVLADPGFVPYVLALVVGDALRATCSAAYLPRPVEFALRVLAWARDFGLGYLPTVEGHRTKLGALITLLEPAARGGLGPTMQMADNIEQLLRELYVISRGAVEQLRPLVQLQPPPPPEVGTSLLLISMYALAARGVLQDLAERADPLIRQLEDAIVLLRLHMRTLSAFFECRFESDGRRLYAVVGDTPDRLGPWPPEAMGDAVSQYCSMYHDAKRALVASLASLRSVITETTAHLGVCDELAAQVSHEDNVLAVVRREIHGFLSVVSGIHARASKLLSGDQVPGFCFMGQFLARWRRLSACYQAARAAAGPEPVAEFVQELHDTWKGLQTERAVVVAPLVSSADQRAAAIREVMAHAPEDAPPQSPAADRVVLTSRRDLGAWGDYSLGPLGQTTAVPDSVDLSRQGLAVTLSMDWLLMNELLRVTDGVFRASAFRPLAGPESPRDLEVRDAGNSLPAPMPMDAQKPEAYGHGPRQADREGAPHSNTPVEDDEMIPEDTVAPPTDLPLTSYQ 18425792B4D7EC9D irak1_human Interleukin-1 receptor-associated kinase 1 IRAK1 IRAK protein protein human Homo sapiens Human MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS DIP protein P51617 original sequence version: 141 DIP protein P51617 original sequence version: 84 DIP protein P51617 original sequence version: 85 DIP protein P51617-1 original sequence version: 103 DIP protein P51617-1 original sequence version: 108 DIP protein P51617 original sequence version: 113 DIP protein P51617 original sequence version: 123 A7ADED75D3A3981D nr2c2_human Nuclear receptor subfamily 2 group C member 2 NR2C2 TAK1 TR4 Orphan nuclear receptor TR4 Testicular receptor 4 Orphan nuclear receptor TAK1 protein protein human Homo sapiens Human MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL DIP protein P49116 original sequence version: 79 DIP protein P49116 original sequence version: 97 5180BDC3F3C8BD79 ul24 nuclear protein UL24 protein protein hhv1 Human herpesvirus 1 HHV-1 Human herpes simplex virus 1 traf6_human TNF receptor-associated factor 6 TRAF6 RNF85 Interleukin-1 signal transducer RING finger protein 85 E3 ubiquitin-protein ligase TRAF6 RING-type E3 ubiquitin transferase TRAF6 protein protein human Homo sapiens Human MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV DIP protein Q9Y4K3 original sequence version: 154 DIP protein Q9Y4K3 original sequence version: 91 DIP protein Q9Y4K3 original sequence version: 114 DIP protein Q9Y4K3 original sequence version: 118 DIP protein Q9Y4K3 original sequence version: 140 DIP protein Q9Y4K3 original sequence version: 159 DIP protein Q9Y4K3 original sequence version: 132 DIP protein Q9Y4K3 original sequence version: 158 DIP protein Q9Y4K3 original sequence version: 171 DIP protein Q9Y4K3 original sequence version: 117 DIP protein Q9Y4K3 original sequence version: 113 5AB9C255CCFEE749 tab1_human TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAB1 MAP3K7IP1 TGF-beta-activated kinase 1-binding protein 1 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 protein protein human Homo sapiens Human MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVVTAP DIP protein Q15750 original sequence version: 74 DIP protein Q15750 original sequence version: 110 DIP protein Q15750 original sequence version: 111 A45743288718983A tab2_human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 KIAA0733 MAP3K7IP2 TAK1-binding protein 2 Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 TGF-beta-activated kinase 1-binding protein 2 protein protein human Homo sapiens Human MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF DIP protein Q9NYJ8 original sequence version: 61 DIP protein Q9NYJ8 original sequence version: 107 DIP protein Q9NYJ8 original sequence version: 99 DIP protein Q9NYJ8 original sequence version: 100 DIP protein Q9NYJ8-1 original sequence version: 100 47BB8709320084D7 tab1-ul37-1 6 9 unspecified role unspecified role prey prey V5 tag V5 tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 14 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association traf6-ul37-1 4 9 unspecified role unspecified role prey prey V5 tag V5 tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 13 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association traf6-ul37-2 7 9 unspecified role unspecified role prey prey V5 tag V5 tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 13 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association irak1-ul37-1 2 9 unspecified role unspecified role prey prey V5 tag V5 tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 10 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association tab2-ul37-1 8 9 unspecified role unspecified role prey prey V5 tag V5 tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 15 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association ul37-traf6-1 5 13 unspecified role unspecified role prey prey human Homo sapiens Human 9 unspecified role unspecified role bait bait P10221:p.Glu1101Ala E1101A mutation mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength predetermined featur predetermined feature predetermined featur certain certain sequence position certain certain certain sequence position certain E A Wed May 02 14:26:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'glu1101ala' Tue Jun 30 16:30:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Glu1101Ala' human Homo sapiens Human physical association physical association nr2c2-ul37-1 1 9 unspecified role unspecified role prey prey V5 tag V5 tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag predetermined featur predetermined feature predetermined featur undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human 11 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association ul24-traf6-1 3 13 unspecified role unspecified role prey prey human Homo sapiens Human 12 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association