DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The human cytomegalovirus UL44 C clamp wraps around DNA. The human cytomegalovirus UL44 C clamp wraps around DNA. Structure (London, England : 1993) 2008 imex curation Komazin-Meredith G., Petrella RJ., Santos WL., Filman DJ., Hogle JM., Verdine GL., Karplus M., Coen DM. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Komazin-Meredith G., Petrella RJ., Santos WL., Filman DJ., Hogle JM., Verdine GL., Karplus M., Coen DM. DIP original experiment: DIP-110810X Structure (London, England : 1993) 2008 IMEx The human cytomegalovirus UL44 C clamp wraps around DNA. dpol_hcmva DNA polymerase catalytic subunit UL54 HFLF2 protein protein hcmva Human cytomegalovirus (strain AD169) (HHV-5) Human herpesvirus 5 HHV-5 MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKHKTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVSPRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPEPRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDPLTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSFDIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHSGLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTRLEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAGSVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCLQDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNHYSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGSNSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFASLYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKWVSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNERRVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMICKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSLDEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVIKRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADGGGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNVLSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC DIP protein P08546 original sequence version: 64 vpap_hcmva DNA polymerase processivity factor UL44 Polymerase accessory protein Protein ICP36 protein protein hcmva Human cytomegalovirus (strain AD169) (HHV-5) Human herpesvirus 5 HHV-5 MDRKTRLSEPPTLALRLKPYKTAIQQLRSVIRALKENTTVTFLPTPSLILQTVRSHCVSKITFNSSCLYITDKSFQPKTINNSTPLLGNFMYLTSSKDLTKFYVQDISDLSAKISMCAPDFNMEFSSACVHGQDIVRESENSAVHVDLDFGVVADLLKWIGPHTRVKRNVKKAPCPTGTVQILVHAGPPAIKFILTNGSELEFTANNRVSFHGVKNMRINVQLKNFYQTLLNCAVTKLPCTLRIVTEHDTLLYVASRNGLFAVENFLTEEPFQRGDPFDKNYVGNSGKSRGGGGGGGSLSSLANAGGLHDDGPGLDNDLMNEPMGLGGLGGGGGGGGKKHDRGGGGGSGTRKMSSGGGGGDHDHGLSSKEKYEQHKITSYLTSKGGSGGGGGGGGGGLDRNSGNYFNDAKEESDSEDSVTFEFVPNTKKQKCG DIP protein P16790 original sequence version: 51 ul44-ul54-1 1 2 unspecified role unspecified role unspecified role unspecified role Region 1221-1242 Region 1221-1242 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 3 unspecified role unspecified role unspecified role unspecified role Region 1-290 Region 1-290 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P16790:p.[Arg165Ala;Lys167Ala;Arg168Ala;Lys171Ala;Lys172Ala] R165A/K167A/R168A/K171A/K172A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain R A certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R165A/K167A/R168A/K171A/K172A'. Wed May 02 16:52:25 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg165ala,lys167ala,arg168ala,lys171ala,lys172ala' Tue Jun 30 19:21:05 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg165Ala;Lys167Ala;Arg168Ala;Lys171Ala;Lys172Ala]' P16790:p.[Lys35Ala;Lys158Ala;Lys224Ala;Lys237Ala] K35A/K158A/K224A/K237A mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain K A certain certain sequence position certain certain certain sequence position certain K A This feature has been corrected as a result of our quality control procedures. The original label was 'K35A/K158A/K224A/K237A'. Wed May 02 18:33:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys35ala,lys158ala,lys224ala,lys237ala' Tue Jun 30 18:36:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys35Ala;Lys158Ala;Lys224Ala;Lys237Ala]' ecolx Escherichia coli direct interaction direct interaction