<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Transducer binding establishes localized interactions to tune sensory rhodopsin II.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="18682222" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2008.04.014" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15719515" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-9291" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Transducer binding establishes localized interactions to tune sensory rhodopsin II.</attribute>
            <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Cisneros DA.,  Oberbarnscheidt L.,  Pannier A.,  Klare JP.,  Helenius J.,  Engelhard M.,  Oesterhelt F.,  Muller DJ.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-9291" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-110809X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="18682222" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2008.04.014" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>atomic force microsc</shortLabel>
            <fullName>atomic force microscopy</fullName>
            <alias type="go synonym" typeAc="MI:0303">AFM</alias>
            <alias type="synonym" typeAc="MI:1041">AFM</alias>
            <alias type="synonym" typeAc="MI:1041">atomic force microsc</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0872" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1372321" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="17502105" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Cisneros DA., Oberbarnscheidt L., Pannier A., Klare JP., Helenius J., Engelhard M., Oesterhelt F., Muller DJ.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-110809X</attribute>
          <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Transducer binding establishes localized interactions to tune sensory rhodopsin II.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>htr2_natph</shortLabel>
          <fullName>Sensory rhodopsin II transducer</fullName>
          <alias type="gene name" typeAc="MI:0301">htr2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">htrII</alias>
          <alias type="gene name synonym" typeAc="MI:0302">HTR-II</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Methyl-accepting phototaxis protein II</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P42259" version="SP_61" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1034515" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" version="SP_121"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_121"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006935" version="SP_121"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" version="SP_121"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009881" version="SP_121"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_121"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0018298" version="SP_121"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_121"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003660" version="SP_121"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004089" version="SP_121"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004090" version="SP_121"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR040913" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1H2S" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2F93" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2F95" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RM8" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GYC" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJE" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJF" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJJ" version="SP_121"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJN" version="SP_121"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P42259"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-35283N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="2257">
          <names>
            <shortLabel>natph</shortLabel>
            <fullName>Natronomonas pharaonis (Natronobacterium pharaonis)</fullName>
          </names>
        </organism>
        <sequence>MSLNVSRLLLPSRVRHSYTGKMGAVFIFVGALTVLFGAIAYGEVTAAAATGDAAAVQEAAVSAILGLIILLGINLGLVAATLGGDTAASLSTLAAKASRMGDGDLDVELETRREDEIGDLYAAFDEMRQSVRTSLEDAKNAREDAEQAQKRAEEINTELQAEAERFGEVMDRCADGDFTQRLDAETDNEAMQSIEGSFNEMMDGIEALVGRIERFADAVSEDAEAVRANAESVMEASEDVNRAVQNISDAAGDQTETVQQIALEMDDVSATTEEVAASADDIAKTARQAAETGEAGRETAETAITEMNEVESRTEQAVASMEELNEDVREIGEVSEMIADIAEQTNILALNASIEAARADGNSEGFAVVADEVKALAEETKAATEEIDDLIGTVQDRTQTTVDDIRETSDQVSEGVETVEDTVDALERIVDSVERTNDGIQEINQSTDAQADAAQKATTMVEDMAATSEQTASDAETAAETTETQAESVKEVFDLIDGLSEQADSLSETLSRTDTEEASAADLDDQPTLAAGDD</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P42259 original sequence version: 87</attribute>
          <attribute name="remark-internal">DIP protein P42259 original sequence version: 94</attribute>
          <attribute name="remark-internal">DIP protein P42259 original sequence version: 66</attribute>
          <attribute name="remark-internal">DIP protein P42259 original sequence version: 77</attribute>
          <attribute name="crc64">CBE8012CC5F278E8</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>bacs2_natph</shortLabel>
          <fullName>Sensory rhodopsin-2</fullName>
          <alias type="gene name" typeAc="MI:0301">sop2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">sopII</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Sensory rhodopsin II</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P42196" version="SP_59" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1034509" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005216" version="SP_119"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_119"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007602" version="SP_119"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009881" version="SP_119"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_119"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0018298" version="SP_119"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001425" version="SP_119"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018229" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GU8" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GUE" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1H2S" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1H68" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1JGJ" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2F93" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2F95" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3QAP" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3QDC" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GYC" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJE" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJF" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJJ" version="SP_119"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JJN" version="SP_119"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-35282N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="2257">
          <names>
            <shortLabel>natph</shortLabel>
            <fullName>Natronomonas pharaonis (Natronobacterium pharaonis)</fullName>
          </names>
        </organism>
        <sequence>MVGLTTLFWLGAIGMLVGTLAFAWAGRDAGSGERRYYVTLVGISGIAAVAYVVMALGVGWVPVAERTVFAPRYIDWILTTPLIVYFLGLLAGLDSREFGIVITLNTVVMLAGFAGAMVPGIERYALFGMGAVAFLGLVYYLVGPMTESASQRSSGIKSLYVRLRNLTVILWAIYPFIWLLGPPGVALLTPTVDVALIVYLDLVTKVGFGFIALDAAATLRAEHGESLAGVDTDAPAVAD</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P42196 original sequence version: 84</attribute>
          <attribute name="remark-internal">DIP protein P42196 original sequence version: 64</attribute>
          <attribute name="remark-internal">DIP protein P42196 original sequence version: 73</attribute>
          <attribute name="crc64">C0E93EAF341B6B19</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-9291-1">
        <names>
          <shortLabel>htr2-sop2-4</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-64056E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15719534" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-9291-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="6">
                <names>
                  <shortLabel>Region 1-114</shortLabel>
                  <fullName>Region 1-114</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-15719540" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>binding region</shortLabel>
                    <fullName>binding-associated region</fullName>
                    <alias type="synonym" typeAc="MI:1041">binding region</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="1"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="114"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>