DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (London, England : 1993) 2008 imex curation Stouffer AL., Ma C., Cristian L., Ohigashi Y., Lamb RA., Lear JD., Pinto LH., DeGrado WF. Only protein-protein interactions in vitro In vitro ms of complexes mass spectrometry studies of complexes ms of complexes predetermined predetermined participant predetermined Stouffer AL., Ma C., Cristian L., Ohigashi Y., Lamb RA., Lear JD., Pinto LH., DeGrado WF. DIP original experiment: DIP-110793X Structure (London, England : 1993) 2008 IMEx The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure (London, England : 1993) 2008 imex curation Stouffer AL., Ma C., Cristian L., Ohigashi Y., Lamb RA., Lear JD., Pinto LH., DeGrado WF. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Stouffer AL., Ma C., Cristian L., Ohigashi Y., Lamb RA., Lear JD., Pinto LH., DeGrado WF. DIP original experiment: DIP-110792X Structure (London, England : 1993) 2008 IMEx The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. m2tm-1 Matrix protein 2 peptide peptide polypeptide oligopeptide oligopeptide polypeptide 9infa Influenza A virus CNDSSDPLVVAASIIGILHLILWILDRL m2tm-2 2 3 unspecified role unspecified role unspecified role unspecified role Region 4-28 Region 4-28 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro direct interaction direct interaction m2tm-3 1 3 unspecified role unspecified role unspecified role unspecified role in vitro In vitro covalent binding covalent binding