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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="18587051" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0711061105" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15711913" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-9389" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Maiti A.,  Morgan MT.,  Pozharski E.,  Drohat AC.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-9389" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-111183X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="2RBA" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="18587051" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0711061105" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="-1">
            <names>
              <shortLabel>in vitro</shortLabel>
              <fullName>In vitro</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Maiti A., Morgan MT., Pozharski E., Drohat AC.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-111183X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>tdg_human</shortLabel>
          <fullName>G/T mismatch-specific thymine DNA glycosylase</fullName>
          <alias type="gene name" typeAc="MI:0301">TDG</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Thymine-DNA glycosylase</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q13569" version="SP_59" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000376611" version="SP_186" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8IUZ6" version="SP_59" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8IZM3" version="SP_59" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-348333" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000139372" version="SP_186" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000392872" version="SP_186" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000287" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003684" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0003690" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004844" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006284" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006285" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006298" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006325" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008263" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019104" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030983" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031402" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031404" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032183" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035511" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0040029" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043621" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043739" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045008" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045995" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0080111" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0140297" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:1902544" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003310" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005122" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015637" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036895" version="SP_186"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="Q13569" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1WYW" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2D07" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RBA" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3UFJ" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3UO7" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3UOB" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4FNC" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JGC" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4XEG" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4Z3A" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4Z47" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4Z7B" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4Z7Z" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5CYS" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FF8" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HF7" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JXY" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5T2W" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6U15" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6U16" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6U17" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110328" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110329" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110357" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3108214" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5221030" version="SP_186"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003202.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-32709N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MEAENAGSYSLQQAQAFYTFPFQQLMAEAPNMAVVNEQQMPEEVPAPAPAQEPVQEAPKGRKRKPRTTEPKQPVEPKKPVESKKSGKSAKSKEKQEKITDTFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNMDVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCSSEPCGFSSNGLIESVELRGESAFSGIPNGQWMTQSFTDQIPSFSNHCGTQEQEEESHA</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q13569 original sequence version: 70</attribute>
          <attribute name="remark-internal">DIP protein Q13569 original sequence version: 99</attribute>
          <attribute name="crc64">33752B26EBC789AE</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-9389-1">
        <names>
          <shortLabel>tdg-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-87957E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15711933" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-9389-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="5">
                <names>
                  <shortLabel>Region 111-308</shortLabel>
                  <fullName>Region 111-308</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-15711938" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>binding region</shortLabel>
                    <fullName>binding-associated region</fullName>
                    <alias type="synonym" typeAc="MI:1041">binding region</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
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                      </xref>
                    </startStatus>
                    <begin position="111"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
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                      </xref>
                    </endStatus>
                    <end position="308"/>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>