DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259461X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259463X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259456X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259467X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259459X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259462X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259454X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259465X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259451X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259455X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259466X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip autoradiography autoradiography Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259452X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259464X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259460X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259457X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip autoradiography autoradiography Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259453X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259458X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008 imex curation Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Zhu W., Shiojima I., Ito Y., Li Z., Ikeda H., Yoshida M., Naito AT., Nishi J., Ueno H., Umezawa A., Minamino T., Nagai T., Kikuchi A., Asashima M., Komuro I. DIP original experiment: DIP-259450X Nature 2008 IMEx IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. wnt3a_mouse Protein Wnt-3a Wnt3a Wnt-3a protein protein mouse Mus musculus Mouse MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK DIP protein P27467 original sequence version: 126 DIP protein P27467 original sequence version: 101 DIP protein P27467 original sequence version: 121 DIP protein P27467 original sequence version: 140 DIP protein P27467 original sequence version: 109 7ADFC5B38A8EFF63 fzd8_mouse Frizzled-8 Fzd8 protein protein mouse Mus musculus Mouse MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGSGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV DIP protein Q61091 original sequence version: 123 DIP protein Q61091 original sequence version: 119 DIP protein Q61091 original sequence version: 108 9DB95F068BC45CD8 o57464_xenla dkk1.S Xdkk-1 dkk1 dkk1-A XELAEV_18036781mg protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MGSNMFPVPLIVFWGFILDGALGFVMMTNSNSIKNVPAAPAGQPIGYYPVSVSPDSLYDIANKYQPLDAYPLYSCTEDDDCALDEFCHSSRNGNSLVCLACRKRRKRCLRDAMCCTGNYCSNGICVPVEQDQERFQHQGYLEETILENYNNADHATMDTHSKLTTSPSGMQPFKGRDGDVCLRSTDCAPGLCCARHFWSKICKPVLDEGQVCTKHRRKGSHGLEIFQRCHCGAGLSCRLQKGEFTTVPKTSRLHTCQRH DIP protein O57464 original sequence version: 45 ibp6_mouse Insulin-like growth factor-binding protein 6 Igfbp6 Igfbp-6 protein protein mouse Mus musculus Mouse MTWDGLPTQPLLMLLMLLFAAGSGSALAGCPGCGAGMQTGCRGGCVEEEDAGSPADGCTEAGGCLRREGQPCGVYSPKCAPGLQCQPRENEEAPLRALLIGQGRCQRARGPSEETTKESKPQGGASRSRDTNHRDRQKNPRTSAAPIRPNPVQDSEMGPCRRHLDSVLQQLQTEVFRGGARGLYVPNCDLRGFYRKQQCRSSQGNRRGPCWCVDPMGQPLPVSPDGQGSTQCSARSSG DIP protein P47880 original sequence version: 111 ibp4_mouse Insulin-like growth factor-binding protein 4 Igfbp4 Igfbp-4 protein protein mouse Mus musculus Mouse MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTELSEIEAIQESLQTSDKDESEHPNNSFNPCSAHDHRCLQKHMAKIRDRSKMKIVGTPREEPRPVPQGSCQSELHRALERLAASQSRTHEDLFIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFQE DIP protein P47879 original sequence version: 113 ibp1_mouse Insulin-like growth factor-binding protein 1 Igfbp1 Igfbp-1 protein protein mouse Mus musculus Mouse MPEFLTVVSWPFLILLSFQIGVAAGAPQPWHCAPCTAERLGLCPPVPASCPEISRPAGCGCCPTCALPMGAACGVATARCAQGLSCRALPGEPRPLHALTRGQGACVPEPAAPATSTLFSSQHEEAKAAVVSADELSESPEMTEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREIADLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVHN DIP protein P47876 original sequence version: 113 ibp4_human Insulin-like growth factor-binding protein 4 IGFBP4 IBP4 protein protein human Homo sapiens Human MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE DIP protein P22692 original sequence version: 113 DIP protein P22692-1 original sequence version: 153 DIP protein P22692 original sequence version: 145 5E8F4638D99F0A94 ibp2_mouse Insulin-like growth factor-binding protein 2 Igfbp2 Igfbp-2 protein protein mouse Mus musculus Mouse MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRAEVLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGTTPQQVADSDDDHSEGGLVENHVDGTMNMLGGGSSAGRKPLKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGRYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQETGGAHAQSVQ DIP protein P47877 original sequence version: 115 mint IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors 179FE6A304E93A16 lrp6_human Low-density lipoprotein receptor-related protein 6 LRP6 protein protein human Homo sapiens Human MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS DIP protein O75581 original sequence version: 116 DIP protein O75581 original sequence version: 95 DIP protein O75581 original sequence version: 131 DIP protein O75581 original sequence version: 112 DIP protein O75581 original sequence version: 136 DIP protein O75581 original sequence version: 59 DIP protein O75581 original sequence version: 103 DIP protein O75581 original sequence version: 100 413D2CF70A5D8B5C fzd8-igfbp1-1 17 24 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 20 unspecified role unspecified role bait bait Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association lrp6-igfbp4-1 18 27 unspecified role unspecified role bait bait Region 20-1370 Region 20-1370 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 25 unspecified role unspecified role prey prey 125I-label 125I-label 125i radiolabel 125i radiolabel I125 125I 125I I125 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined mouse Mus musculus Mouse physical association physical association fzd8-igfbp6-1 1 22 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 20 unspecified role unspecified role bait bait Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association lrp6-igfbp1-1 7 24 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 27 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association fzd8-igfbp2-1 5 26 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 20 unspecified role unspecified role bait bait Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association fzd8-igfbp4-1 9 20 unspecified role unspecified role bait bait Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 25 unspecified role unspecified role prey prey 125I-label 125I-label 125i radiolabel 125i radiolabel I125 125I 125I I125 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined mouse Mus musculus Mouse physical association physical association lrp6-igfbp4-2 8 23 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 27 unspecified role unspecified role bait bait Region 889-1244 Region 889-1244 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Region 282-628 Region 282-628 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Region 1248-1361 Region 1248-1361 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association igfbp4-fzd8-1 6 23 unspecified role unspecified role bait bait V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 20 unspecified role unspecified role prey prey Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association lrp6-igfbp2-1 10 26 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 27 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association fzd8-igfbp4-2 14 23 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 20 unspecified role unspecified role bait bait Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association lrp6-wnt3a-2 12 19 unspecified role unspecified role prey prey 125I-label 125I-label 125i radiolabel 125i radiolabel I125 125I 125I I125 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 27 unspecified role unspecified role bait bait Region 20-1370 Region 20-1370 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association lrp6-igfbp4-3 4 23 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Region 167-245 Region 167-245 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 27 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association fzd8-igfbp4-3 2 23 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Region 167-245 Region 167-245 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 20 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association lrp6-igfbp4-4 3 23 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 27 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association igfbp4-lrp6-1 11 23 unspecified role unspecified role bait bait V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 27 unspecified role unspecified role prey prey Region 889-1244 Region 889-1244 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Region 282-628 Region 282-628 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Region 1248-1361 Region 1248-1361 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association dkk1-lrp6-3 13 21 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 27 unspecified role unspecified role prey prey Region 889-1244 Region 889-1244 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association fzd8-wnt3a-2 16 19 unspecified role unspecified role prey prey 125I-label 125I-label 125i radiolabel 125i radiolabel I125 125I 125I I125 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 20 unspecified role unspecified role bait bait Region 1-178 Region 1-178 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association lrp6-igfbp6-1 15 22 unspecified role unspecified role prey prey V5-tag V5-tag v5 tag v5 tag GKPIPNPLLGLDST epitope tag GKPIPNPLLGLDST epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 27 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association