DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Zhong L., Li B., Mah CS., Govindasamy L., Agbandje-McKenna M., Cooper M., Herzog RW., Zolotukhin I., Warrington KH., Weigel-Van Aken KA., Hobbs JA., Zolotukhin S., Muzyczka N., Srivastava A. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhong L., Li B., Mah CS., Govindasamy L., Agbandje-McKenna M., Cooper M., Herzog RW., Zolotukhin I., Warrington KH., Weigel-Van Aken KA., Hobbs JA., Zolotukhin S., Muzyczka N., Srivastava A. DIP original experiment: DIP-111070X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. capsd_aav2s Capsid protein VP1 VP1 protein protein aav-2 Adeno-associated virus 2 (isolate Srivastava/1982) AAV-2 MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRTTNPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL This sequence has been withdrawn from Uniprot. 980BEEF46908390B ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG cap-ub-1 1 2 unspecified role unspecified role bait bait P03135:p.Tyr730Phe Y730F mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'Y730F'. Wed May 02 16:09:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr730phe' Tue Jun 30 18:49:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr730Phe' P03135:p.Tyr444Phe Y444F mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'Y444F'. Wed May 02 19:58:44 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr444phe' Tue Jun 30 20:08:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr444Phe' human Homo sapiens Human 3 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association