DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Murakami K., Stewart M., Nozawa K., Tomii K., Kudou N., Igarashi N., Shirakihara Y., Wakatsuki S., Yasunaga T., Wakabayashi T. Only protein-protein interactions in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Murakami K., Stewart M., Nozawa K., Tomii K., Kudou N., Igarashi N., Shirakihara Y., Wakatsuki S., Yasunaga T., Wakabayashi T. DIP original experiment: DIP-111023X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Murakami K., Stewart M., Nozawa K., Tomii K., Kudou N., Igarashi N., Shirakihara Y., Wakatsuki S., Yasunaga T., Wakabayashi T. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Murakami K., Stewart M., Nozawa K., Tomii K., Kudou N., Igarashi N., Shirakihara Y., Wakatsuki S., Yasunaga T., Wakabayashi T. DIP original experiment: DIP-111024X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Murakami K., Stewart M., Nozawa K., Tomii K., Kudou N., Igarashi N., Shirakihara Y., Wakatsuki S., Yasunaga T., Wakabayashi T. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Murakami K., Stewart M., Nozawa K., Tomii K., Kudou N., Igarashi N., Shirakihara Y., Wakatsuki S., Yasunaga T., Wakabayashi T. DIP original experiment: DIP-111025X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. tpm1_rabit Tropomyosin alpha-1 chain TPM1 TPMA Tropomyosin-1 Alpha-tropomyosin protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI DIP protein P58772 original sequence version: 47 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments mint E25609F597A72F4D tmn Tropomyosin N terminus peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) GAASMDAIKKKMQMLKLDKENALDRAEQLENEVARLKKLV tmc Tropomyosin C terminus peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) GELLSKNYHLENEVARLKKLVDDLEDELYAQKLKYKAISEELDHALNDMTSI p12620-1 Troponin T, fast skeletal muscle isoforms TNNT3 protein protein chick Gallus gallus (Chicken) Chicken MSDTEEVEHGEEEYEEEAHEAEEVHEEEVHEPAPPPEEAPEEEEKPRIKLTAPKIPEGEKVDFDDIQKKRQNKDLIELQALIDSHFEARRKEEEELVALKERIEKRRAERAEQQRIRAEKEKERQARLAEEKARREEEDAKRKAEDDLKKKKALSSMGASYSSYLAKADQKRGKKQTARETKKKVLAERRKPLNIDHLNEDKLRDKAKELWDWLYQLQTEKYDFAEQIKRKKYEIVTLRNRIDQAQKHSKKAGAKGKVGGRWK DIP protein P12620-1 original sequence version: 63 acts_rabit Actin, alpha skeletal muscle ACTA1 ACTA Alpha-actin-1 protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF DIP protein P68135 original sequence version: 41 DIP protein P68135 original sequence version: 27 DIP protein P68135 original sequence version: 28 DIP protein P68135 original sequence version: 96 DIP protein P68135 original sequence version: 29 DIP protein P68135 original sequence version: 89 DIP protein P68135 original sequence version: 39 DIP protein P68135 original sequence version: 42 DIP protein P68135 original sequence version: 59 DIP protein P68135 original sequence version: 55 DIP protein P68135 original sequence version: 60 DIP protein P68135 original sequence version: 65 DIP protein P68135 original sequence version: 67 DIP protein P68135 original sequence version: 63 DIP protein P68135 original sequence version: 68 DIP protein P68135 original sequence version: 79 DIP protein P68135 original sequence version: 88 DIP protein P68135 original sequence version: 84 DIP protein P68135 original sequence version: 101 DIP protein P68135 original sequence version: 94 DIP protein P68135 original sequence version: 95 DIP protein P68135 original sequence version: 97 DIP protein P68135 original sequence version: 100 DIP protein P68135 original sequence version: 102 DIP protein P68135 original sequence version: 83 DF2A3A046346A179 acta1-tpm1-2 1 4 unspecified role unspecified role unspecified role unspecified role P58772:p.[Lys15Leu;Ala18Leu;Ala22Leu] K15L/A18L/A22L mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain A L certain certain sequence position certain certain certain sequence position certain A L certain certain sequence position certain certain certain sequence position certain K L This feature has been corrected as a result of our quality control procedures. The original label was 'K15L/A18L/A22L'. Wed May 02 15:58:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys15leu,ala18leu,ala22leu' Tue Jun 30 16:33:05 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys15Leu;Ala18Leu;Ala22Leu]' ecolx Escherichia coli 8 unspecified role unspecified role unspecified role unspecified role rabit Oryctolagus cuniculus (Rabbit) Rabbit direct interaction direct interaction tmc-tmn-1 2 6 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 5 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction tmc-tmn-2 3 7 unspecified role unspecified role unspecified role unspecified role Region 58-112 Region 58-112 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 6 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 5 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction