DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu High blood pressure arising from a defect in vascular function. High blood pressure arising from a defect in vascular function. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Michael SK., Surks HK., Wang Y., Zhu Y., Blanton R., Jamnongjit M., Aronovitz M., Baur W., Ohtani K., Wilkerson MK., Bonev AD., Nelson MT., Karas RH., Mendelsohn ME. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Michael SK., Surks HK., Wang Y., Zhu Y., Blanton R., Jamnongjit M., Aronovitz M., Baur W., Ohtani K., Wilkerson MK., Bonev AD., Nelson MT., Karas RH., Mendelsohn ME. DIP original experiment: DIP-68808X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx High blood pressure arising from a defect in vascular function. High blood pressure arising from a defect in vascular function. High blood pressure arising from a defect in vascular function. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Michael SK., Surks HK., Wang Y., Zhu Y., Blanton R., Jamnongjit M., Aronovitz M., Baur W., Ohtani K., Wilkerson MK., Bonev AD., Nelson MT., Karas RH., Mendelsohn ME. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Michael SK., Surks HK., Wang Y., Zhu Y., Blanton R., Jamnongjit M., Aronovitz M., Baur W., Ohtani K., Wilkerson MK., Bonev AD., Nelson MT., Karas RH., Mendelsohn ME. DIP original experiment: DIP-68807X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx High blood pressure arising from a defect in vascular function. High blood pressure arising from a defect in vascular function. High blood pressure arising from a defect in vascular function. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Michael SK., Surks HK., Wang Y., Zhu Y., Blanton R., Jamnongjit M., Aronovitz M., Baur W., Ohtani K., Wilkerson MK., Bonev AD., Nelson MT., Karas RH., Mendelsohn ME. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Michael SK., Surks HK., Wang Y., Zhu Y., Blanton R., Jamnongjit M., Aronovitz M., Baur W., Ohtani K., Wilkerson MK., Bonev AD., Nelson MT., Karas RH., Mendelsohn ME. DIP original experiment: DIP-68809X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx High blood pressure arising from a defect in vascular function. rtkn_mouse Rhotekin Rtkn protein protein mouse Mus musculus Mouse MFSRNHRSRITVARGSALEMEFKRGRFRLSFFSESPEDTELQRKLDHEIRMRDGACKLLAACSQREQALEATKSLLVCNSRILSYMGELQRRKEAQVLEKTGRRPSDSVQPAQHSPCRGRVCISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQIGEQIQDTEMVLVDRTLTDISFQNNVLFAEAEPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGKRVRASLDSAGASGNSPVLLPTPAVGGPRFHLLAHTTLTLEEVQDGFRTHDLTLTSHEENPAWLPLYGSVCCRLAAQPLCMIQPTASGALRVQQAGELQNGTLVHGVLKGTNLFCYWRSEDADTGQEPLFTIVINKETRVRAGELEQAPEWPFTLSISNKYGDDEVTNTLQLESREALQNWMEALWQLFFDMSQWRHCCDEVMKIETPAPRKPPQALAKQGSLYHEMAIEPLDDIAAVTDILAQREGTRLEPSPPWLAMFTDQPALPSSCSPASVAPVPTWMQPLPWGRPRTFSLDAAPADHSLGPSRSVAPLPPQRSPKSRGFYSKSQLGPWLQSPV DIP protein Q8C6B2 original sequence version: 41 DIP protein Q8C6B2 original sequence version: 57 0934EEBF09B12A3E mypt1_mouse Protein phosphatase 1 regulatory subunit 12A Myosin phosphatase-targeting subunit 1 Ppp1r12a Mypt1 protein protein mouse Mus musculus Mouse MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERVMLRDARQWLNSGHISDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMETVNKVGQTAFDVADEDILGYLEELQKKQTLLHSEKRDKKSPLIESTANMENNQPQKAFKNKETLIIEPEKNASRIESLEHEKADEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMASVSNAHTSSTQAAPAAVTAPTLSSNQGTPTSPVKKFPISTTKISPKEEERKDESPASWRLGLRKTGSYGALAEISASKEAQKEKDTAGVMRSASSPRLSSSLDNKEKEKDNKGTRLAYVTPTIPRRLASTSDIEEKENRESSSLRTSSSYTRRKWEDDLKKNSSINEGSTYHRSCSFGRRQDDLISCSVPSTTSTPTVTSAAGLQRSLPSSTSTAAKTPPGSSSAGTQSSTSNRLWAEDSTEKEKDSAPTAVTIPVAPTVVNAAAPSTTTLTTTTAGTVSEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESEASREDEYKQKYSRTYDETYTRYRPVSTSSSSAPSSSSLSTLGSTLYASSQLNRPNSLVGITSAYSRGLAKENEREGEKKEEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQERQSDTEDGSSKRETQTDSVSRYDSSSTSSSDRYDSLLGRSASYSYLEDRKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSQLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK DIP protein Q9DBR7 original sequence version: 54 C466573AC1DFC81F rhoa_mouse Transforming protein RhoA Rhoa Arha Arha2 protein protein mouse Mus musculus Mouse MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLIL DIP protein Q9QUI0 original sequence version: 76 DIP protein Q9QUI0 original sequence version: 77 DIP protein Q9QUI0 original sequence version: 100 C4C8BDC31FF858BC p0c605-1 cGMP-dependent protein kinase 1 Prkg1 Prkg1b Prkgr1a Prkgr1b cGMP-dependent protein kinase I CGK1-alpha protein protein mouse Mus musculus Mouse MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF DIP protein P0C605-1 original sequence version: 7 ppp1r12a-prkg1-1 2 7 unspecified role unspecified role prey prey mouse Mus musculus Mouse 5 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 905-1004 Region 905-1004 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli physical association physical association prkg1-ppp1r12a-1 3 7 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli 5 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association rtkn-rhoa-10 1 6 unspecified role unspecified role prey prey mouse Mus musculus Mouse 4 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli physical association physical association