DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68427X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68422X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68420X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68429X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro fps fluorescence polarization spectroscopy Fluorescence anisotropy FPS FPS Fluorescence anisotropy fps predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68423X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68421X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68428X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68424X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro fps fluorescence polarization spectroscopy Fluorescence anisotropy FPS FPS Fluorescence anisotropy fps predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68431X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68426X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68425X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (London, England : 1993) 2008 imex curation Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. Only protein-protein interactions in vitro In vitro nmr nuclear magnetic resonance NMR NMR nmr predetermined predetermined participant predetermined Zeng L., Zhang Q., Gerona-Navarro G., Moshkina N., Zhou MM. DIP original experiment: DIP-68430X Structure (London, England : 1993) 2008 IMEx Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. tatk50acfl Tat-K50ac-Fl peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) GGGGSYGRKKRRQRC h3k9-1 H3K9 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ARTKQTARKSTGGKA nh3k9ac H3-K9ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) RTKQTARKSTGGKAP h3k14ac H3-K14ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ARKSTGGKAPRKQLA tatk50ac Tat-K50ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) LGISYGRKKRRQRRA p53k382ac p53-K382ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) QSTSRHKKLMFKTEG h3k36ac H3-K36ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) ATGGVKKPHRYK h4k16ac H4-K16ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) GLGKGGAKRHRKVLR kat2b_human Histone acetyltransferase KAT2B P300/CBP-associated factor PCAF Lysine acetyltransferase 2B Histone acetyltransferase PCAF KAT2B Spermidine acetyltransferase KAT2B protein protein human Homo sapiens Human MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK DIP protein Q92831 original sequence version: 159 DIP protein Q92831 original sequence version: 153 DIP protein Q92831 original sequence version: 84 72F516E8BC00CC0C cbp_human CREB-binding protein CREBBP CBP Histone lysine acetyltransferase CREBBP Protein-lysine acetyltransferase CREBBP protein protein human Homo sapiens Human MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL DIP protein Q92793 original sequence version: 134 DIP protein Q92793-1 original sequence version: 171 DIP protein Q92793 original sequence version: 171 DIP protein Q92793 original sequence version: 185 DIP protein Q92793 original sequence version: 106 DIP protein Q92793 original sequence version: 104 DIP protein Q92793 original sequence version: 112 DIP protein Q92793 original sequence version: 135 DIP protein Q92793 original sequence version: 139 DIP protein Q92793 original sequence version: 157 DIP protein Q92793 original sequence version: 177 DIP protein Q92793 original sequence version: 168 DIP protein Q92793-1 original sequence version: 174 DIP protein Q92793 original sequence version: 146 DIP protein Q92793 original sequence version: 161 DIP protein Q92793 original sequence version: 172 3BEA9B8558BA1A5E h4k20ac H4-K20ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) GGAKRHRKVLRDNIQ nh3k36ac H3-K36ac peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) APATGGVKKPHRYRP kat2b-nh3k9ac-1 1 15 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-h4k20ac-1 3 23 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 22 unspecified role unspecified role unspecified role unspecified role Region 1082-1197 Region 1082-1197 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h4k16ac-kat2b-1 4 20 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-p53k382ac-1 5 18 unspecified role unspecified role unspecified role unspecified role Region 5-12 Region 5-12 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 22 unspecified role unspecified role unspecified role unspecified role Region 1082-1197 Region 1082-1197 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction kat2b-nh3k36ac-1 11 24 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-nh3k36ac-1 6 24 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 22 unspecified role unspecified role unspecified role unspecified role Region 1082-1197 Region 1082-1197 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h3k14ac-kat2b-1 7 16 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction kat2b-tatk50acfl-1 9 13 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction kat2b-tatk50ac-1 12 17 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h3k9ac-kat2b-1 10 14 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction crebbp-p53k382ac-2 2 18 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 22 unspecified role unspecified role unspecified role unspecified role Region 1082-1197 Region 1082-1197 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction h3k36ac-kat2b-1 8 19 unspecified role unspecified role unspecified role unspecified role in vitro In vitro 21 unspecified role unspecified role unspecified role unspecified role Region 719-832 Region 719-832 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction