DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Confinement of caspase-12 proteolytic activity to autoprocessing. Confinement of caspase-12 proteolytic activity to autoprocessing. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Roy S., Sharom JR., Houde C., Loisel TP., Vaillancourt JP., Shao W., Saleh M., Nicholson DW. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Roy S., Sharom JR., Houde C., Loisel TP., Vaillancourt JP., Shao W., Saleh M., Nicholson DW. DIP original experiment: DIP-68519X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Confinement of caspase-12 proteolytic activity to autoprocessing. Confinement of caspase-12 proteolytic activity to autoprocessing. Confinement of caspase-12 proteolytic activity to autoprocessing. Proceedings of the National Academy of Sciences of the United States of America 2008 imex curation Roy S., Sharom JR., Houde C., Loisel TP., Vaillancourt JP., Shao W., Saleh M., Nicholson DW. Only protein-protein interactions in vitro In vitro protease assay protease assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Roy S., Sharom JR., Houde C., Loisel TP., Vaillancourt JP., Shao W., Saleh M., Nicholson DW. DIP original experiment: DIP-68520X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Confinement of caspase-12 proteolytic activity to autoprocessing. caspc_rat Caspase-12 Casp12 protein protein rat Rattus norvegicus (Rat) Rat MAAKRTHERDPIYKIKGLAKDMLDGVFDDLMDKNVLNGDELLKIGEGASLILSKAENLVESFFEKTEMAGKIFAGHIANSDKQLSLQFPSDDEEDELQKMFTPSSASESRGKVEDEEMEVNVGVAHASHLMLTVPQGIQSTEVQDSLKLCSRDWFCTMKTERAEEIYPVMEKEGRTRLALIICNKKFDYLFDRDDAETDILNMKELLQNLGYSVVIKENLTAQEMETELMKFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFTIFNNSNCPSLRNKPKILIMQACRGRHTGTIWVSTSKGIATADTDEECVLSHRWNNSITKAHVETDFIAFKSSTPHNISWKVGKSGSLFISKLIDCFKKYCWCYHLEEIFRKVQYSFEVPGELTQMPTIERVSMTRYFYLFPGN DIP protein Q920D5 original sequence version: 79 DIP protein Q920D5 original sequence version: 40 E00809BBC61461AC casp1_rat Caspase-1 Casp1 Il1bc Il1bce Interleukin-1 beta convertase Interleukin-1 beta-converting enzyme p45 protein protein rat Rattus norvegicus (Rat) Rat MADKVLRAKRKQFINSVSVGTINGLLDELLEKRVLNQEEMDTIKLANITVMEKARDLCDHVTKKGPRASQMFITYICNEDCYLAEILELQSGPSAETVFVTEDSKGGHPFSSETKEKLNKEGGAFPGPSGSLKFCPLEIAQKLWKENHSEIYPIMKTPTRTRLALIICNTDFQHLSRRVGADVDLREMKLLLQDLGYTVKVKENLTALEMTKELKEFAACPEHKTSDSTFLVFMSHGLQEGICGITYSNEVADILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVGNSEEGFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPDSRLQMPTTERVTLTKRFYLFPGH DIP protein P43527 original sequence version: 65 casp1-casp12-2 1 4 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 3 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association casp12-casp12-1 2 3 enzyme target enzyme target substrate substrate unspecified role unspecified role Q920D5:p.Asp319Ala D319A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D319A'. Wed May 02 17:30:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp319ala' Tue Jun 30 19:31:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp319Ala' in vitro In vitro 3 enzyme enzyme unspecified role unspecified role Q920D5:p.Cys299Ala C299A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain C A This feature has been corrected as a result of our quality control procedures. The original label was 'C299A'. Wed May 02 19:52:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys299ala' Tue Jun 30 20:00:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys299Ala' ecolx Escherichia coli direct interaction direct interaction