IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3. Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3. Journal of immunology (Baltimore, Md. : 1950) 2008 imex curation Moesta AK., Norman PJ., Yawata M., Yawata N., Gleimer M., Parham P. All KIRs must be human in origin, not least because UniProt does not give any IDs for other species. DSP=75 reffed from pmid:19858347 The KIRs used to make the fusion proteins are stated to be of alleles:-KIR2DL1*003, KIR2DL2*001, and KIR2DL3*001. Uniprot gives the sequence for KIR2DL1*001. Differences in the KIR2DL1*003 variant as compared to the KIR2DL1*001 sequence are:-P37R and P135L. (https://www.ebi.ac.uk/cgi-bin/ipd/kir/get_allele.cgi?2DL1*00301) peropa@stanford.edu 18-Apr-2017: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro affinity chrom affinity chromatography technology Affinity purification Affinity purification affinity chrom antibody detection identification by antibody antibody detection Moesta AK., Norman PJ., Yawata M., Yawata N., Gleimer M., Parham P. All KIRs must be human in origin, not least because UniProt does not give any IDs for other species. LABScreen single-Ag bead sets (One Lambda) were used: Various HLA Class 1 molecules were bound to beads and incubated with KIR2DL1/2/3-Fc protein. Binding was detected by fluorescence emitted by a Phycoerythrin conjugated anti-Fc antibody. The KIRs used to make the fusion proteins are stated to be of alleles:-KIR2DL1*003, KIR2DL2*001, and KIR2DL3*001. Uniprot gives the sequence for KIR2DL1*001. Differences in the KIR2DL1*003 variant as compared to the KIR2DL1*001 sequence are:-P37R and P135L. (https://www.ebi.ac.uk/cgi-bin/ipd/kir/get_allele.cgi?2DL1*00301) peropa@stanford.edu Accepted 2017-MAR-16 AT 12:00 GMT AT 12:00 GMT by ORCHARD Journal of immunology (Baltimore, Md. : 1950) 2008 Only protein-protein interactions imex curation imex curation q7ynw6_human HLA-C HLA-Cw protein protein human Homo sapiens Human MRVMAPRTLILLLSGALALTETWACSHSMKYFFTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMCGCDLGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVMVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA D52DF8886B5FCE22 q5rip0_human HLA-Cw HLA-C protein protein human Homo sapiens Human MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA 26454A7EE68151DA hlac_human HLA class I histocompatibility antigen, C alpha chain HLA-Cw Human leukocyte antigen C HLAC HLA-C protein protein human Homo sapiens Human MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA DIP protein P30504 original sequence version: 126 59C23D95FD1D0BC8 ki2l1_human Killer cell immunoglobulin-like receptor 2DL1 KIR2DL1 CD158 antigen-like family member A CD158A NKAT1 MHC class I NK cell receptor Natural killer-associated transcript 1 p58 natural killer cell receptor clones CL-42/47.11 p58.1 MHC class-I-specific NK receptor protein protein human Homo sapiens Human MSLLVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQPGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP mint 3DFBF2D6FDCE1D1E q5d1w8_human HLA-Cw HLA-C HLA-C*04 variant protein protein human Homo sapiens Human MRVMAPRTLILLLSGALALTETWAGSHSMRYFSTSVSWPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPREPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQRMFGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWKPSSQPTIPIVGIVAGLAVLAVLAVLGAMVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA E883EB3968658DCB v6dz76_human HLA-B protein protein human Homo sapiens Human MLVMAPRTVLLLLSAALALTETWAGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQICKAKAQTDRVGLRNLRGYYNQSEDGSHTWQTMYGCDMGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRHLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLQEPCTLRWKPSSQSTIPIVGIVAGLAVLVVTVAVVAVVAAVMCRRKSSGGKGGSYSQAASSDSAQGSDVSLTA 04522E97C1E11C40 c1k0y5_human HLA-Cw HLA C HLA-C protein protein human Homo sapiens Human MRVMAPRTLLLLLSGALALTETWACSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQTDRVNLRKLRGYYNQSEAGSHIIQRMYGCDLGPDGRLLRGHDQLAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA FDF703B7AFB05FDD d2iyk1_human HLA-B protein protein human Homo sapiens Human MRVTAPRTVLLLLSGALALTETWAGSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTIPIVGIVAGLAVLAVVVIGAVVATVMCRRKSSGGKGGSYSQAASSDSAQGSDVSLTA 481B4C6876CB0E85 q5qt33_human HLA-C HLA-Cw HLAC protein protein human Homo sapiens Human MRVMAPRTLILLLSGALALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA 45876CB22256DE80 q7yqb1_human HLA-C HLA-Cw protein protein human Homo sapiens Human MRVMAPRTLLLLLSGALALTETWACSHSMRYFYTAVSRPSRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGECVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPTEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA 64AD7B8C2BCD5D6B a0a142ja41_human HLA-C HLA-Cw*18GB protein protein human Homo sapiens Human MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQRMFGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWKPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA 8A78BCC48E4327CB ki2l2_human Killer cell immunoglobulin-like receptor 2DL2 KIR2DL2 CD158B1 NKAT6 CD158 antigen-like family member B1 MHC class I NK cell receptor Natural killer-associated transcript 6 p58 natural killer cell receptor clone CL-43 protein protein human Homo sapiens Human MSLMVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHECRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVIGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYAELPNAESRSKVVSCP 5B54C548F5CF3FBF ki2l3_human Killer cell immunoglobulin-like receptor 2DL3 KIR2DL3 KIRCL23 NKAT2 CD158B2 MHC class I NK cell receptor Natural killer-associated transcript 2 NKAT2a NKAT2b p58 natural killer cell receptor clone CL-6 p58.2 MHC class-I-specific NK receptor Killer inhibitory receptor cl 2-3 KIR-023GB CD158 antigen-like family member B2 protein protein human Homo sapiens Human MSLMVVSMVCVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLHVLIGTSVVIILFILLLFFLLHRWCCNKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAEP mint Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis C21EAFF80EA9AAB2 1c03_human HLA class I histocompatibility antigen, Cw-3 alpha chain HLA-C HLAC MHC class I antigen Cw*3 protein protein human Homo sapiens Human MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted). 47E55680EA1F6D97 c9e8w1_human HLA-Cw Cw*1701 HLA-C protein protein human Homo sapiens Human MRVMAPQALLLLLSGALALIETWAGSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEAGSHTIQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQISQRKLEAAREAEQLRAYLEGECVEWLRGYLENGKETLQRAERPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLQEPCTLRWKPSSQPTIPNLGIVSGPAVLAVLAVLAVLAVLGAVVAAVIHRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA D5DDCE6361D93AA2 hla_b-kir2dl2-1 1 9 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4A-1 B4601 allele hla_b-kir2dl2-2 1 7 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined direct interaction direct interaction Fig 4A-2 B7301 allele hla_b-kir2dl3-3 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 9 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4A-3 B4601 allele hla_b-kir2dl2-3 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 7 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4A-4 B7301 allele hla_b-kir2dl3-4 1 5 unspecified role unspecified role prey prey pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 6 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4A-5, 4B-20, 5 C0401 allele hla_c-kir2dl1-8 1 6 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-21,5 C0401 allele hla_c-kir2ds4-9 1 2 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-1 C0102 allele hla_c-kir2ds4-10 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 15 unspecified role unspecified role bait bait gly115arg variant variant certain certain sequence position certain certain certain sequence position certain G R tyr140ser,ile119leu variant variant certain certain sequence position certain certain certain sequence position certain Y S certain certain sequence position certain certain certain sequence position certain I L direct interaction direct interaction Fig 4B-4,5 C0302, C0304 and C0303 alleles;all alleles showed similar binding. I119L variant:dbSNP:rs1071649; Y140S variant dbSNP:rs713032; G115R variant dbSNP:rs1131122 hla_c-kir2dl3-8 1 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 15 unspecified role unspecified role bait bait tyr140ser,ile119leu variant variant certain certain sequence position certain certain certain sequence position certain Y S certain certain sequence position certain certain certain sequence position certain I L gly115arg variant variant certain certain sequence position certain certain certain sequence position certain G R direct interaction direct interaction Fig 4A, 4B-3,5 C0302, C0304 and C0303 alleles;all alleles showed similar binding. I119L variant:dbSNP:rs1071649; Y140S variant dbSNP:rs713032; G115R variant dbSNP:rs1131122 hla_c-kir2dl2-1 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 2 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-2,5 C0102 allele hla_c-kir2dl2-2 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 6 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-22,5 C0401 allele weak binding hla_c-kir2dl2-3 1 4 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-9,5 C0702 allele hla_c-kir2dl2-4 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 4 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-10,5 C0702 allele hla_c-kir2dl3-9 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 4 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-12,5 C0801 allele hla_c-kir2dl3-10 1 4 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-11,5 C0801 allele hla_c-kir2dl2-5 1 4 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-13,5 C1402 allele hla_c-kir2dl2-6 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 4 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-14,5 C1402 allele hla_c-kir2dl3-11 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 3 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-25,5 C0501 allele hla_c-kir2dl3-12 1 4 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-15,5 C1601 allele hla_c-kir2dl2-7 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 4 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-16,5 C1601 allele hla_c-kir2ds4-11 1 5 unspecified role unspecified role prey prey pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 11 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-17,5 C0202 allele hla_c-kir2dl1-9 1 11 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-1,5 C0202 allele hla_c-kir2dl2-8 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 11 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-19,5 C0202 allele hla_c-kir2dl3-13 1 5 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L 3 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-23,5 C0501 allele hla_c-kir2dl1-10 1 3 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-24,5 C0501 allele hla_c-kir2dl1-11 1 5 unspecified role unspecified role prey prey pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 10 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-26,5 C0602 allele hla_c-kir2dl1-12 1 10 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-27,5 C0602 allele hla_c-kir2dl2-9 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 10 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-28,5 C0602 allele;weak interaction hla_c-kir2dl1-13 1 5 unspecified role unspecified role prey prey pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 8 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-29,5 C1502 allele hla_c-kir2dl1-14 1 8 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-30,5 C1502 allele;weak interaction hla_c-kir2dl1-15 1 5 unspecified role unspecified role prey prey pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 16 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-31,5 C1701 allele hla_c-kir2dl1-16 1 16 unspecified role unspecified role bait bait 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. direct interaction direct interaction Fig 4B-32,5 C1701 allele hla_c-kir2dl2-10 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 16 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-33,5 C1701 allele hla_c-kir2dl1-17 1 5 unspecified role unspecified role prey prey pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 12 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-34,5 C1802 allele hla_c-kir2dl1-18 1 13 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 12 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-35,5 C1802 allele hla_c-kir2dl2-11 1 14 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 12 unspecified role unspecified role bait bait direct interaction direct interaction Fig 4B-36,5 C1802 allele;weak interaction hla_c-kir2dl2-12 1 5 unspecified role unspecified role prey prey pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 11 unspecified role unspecified role bait bait direct interaction direct interaction Fig 5 C0202 allele hla_c-kir2dl2-13 1 5 unspecified role unspecified role prey prey region fc-igg tag fc-igg tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined pro37arg,pro135leu variant variant certain certain sequence position certain certain certain sequence position certain P R certain certain sequence position certain certain certain sequence position certain P L trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 3 unspecified role unspecified role bait bait direct interaction direct interaction Fig 5 C0501 allele