DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-113598X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-113595X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-249806X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-113597X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay western blot western blot Immuno blot Immuno blot Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-249805X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-249803X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-113600X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-249802X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay western blot western blot Immuno blot Immuno blot Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-113599X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-249804X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature structural & molecular biology 2008 imex curation Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. Only protein-protein interactions in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Wu J., Tseng YD., Xu CF., Neubert TA., White MF., Hubbard SR. DIP original experiment: DIP-113596X Nature structural & molecular biology 2008 IMEx Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. irs2_mouse Insulin receptor substrate 2 Irs2 4PS protein protein mouse Mus musculus Mouse MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEASAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDNYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMSMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRATFSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSAPKQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYKASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALRGGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGTFGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYPLPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSLQQPLPPAPGDLYRLPPASAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPPKPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAVPPVPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQPGDKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVKE DIP protein P81122 original sequence version: 60 823A5458DA21C9C7 igf1r_human Insulin-like growth factor 1 receptor Insulin-like growth factor I receptor IGF1R protein protein human Homo sapiens Human MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC DIP protein P08069 original sequence version: 170 DIP protein P08069 original sequence version: 109 DIP protein P08069 original sequence version: 139 DIP protein P08069 original sequence version: 185 AE8A735F87F745C8 p06213-1 Insulin receptor INSR HIR-B protein protein human Homo sapiens Human MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS DIP protein P06213-1 original sequence version: 159 DIP protein P06213-1 original sequence version: 135 irs2-insr-5 4 12 unspecified role unspecified role bait bait Region 602-637 Region 602-637 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain P81122:p.Tyr621Ala Y621A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y621A'. Wed May 02 16:24:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr621ala' Tue Jun 30 20:26:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr621Ala' P81122:p.Tyr624Ala Y624A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y624A'. Wed May 02 14:46:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr624ala' Tue Jun 30 17:53:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr624Ala' P81122:p.Asp627Ala D627A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D627A'. Wed May 02 19:55:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp627ala' Tue Jun 30 17:45:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp627Ala' P81122:p.Tyr628Phe Y628F mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'Y628F'. Wed May 02 16:55:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr628phe' Tue Jun 30 16:14:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr628Phe' P81122:p.Gly629Ala G629A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain G A This feature has been corrected as a result of our quality control procedures. The original label was 'G629A'. Wed May 02 19:50:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly629ala' Tue Jun 30 18:31:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly629Ala' P81122:p.Ile631Ala I631A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain I A This feature has been corrected as a result of our quality control procedures. The original label was 'I631A'. Wed May 02 15:40:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile631ala' Tue Jun 30 16:18:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile631Ala' P81122:p.Ile633Ala I633A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain I A This feature has been corrected as a result of our quality control procedures. The original label was 'I633A'. Wed May 02 16:24:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile633ala' Tue Jun 30 18:26:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile633Ala' His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 14 unspecified role unspecified role prey prey Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction insr-insr-2 7 14 enzyme enzyme unspecified role unspecified role Region 956-1283 Region 956-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 14 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P06213-1:p.Asp1159Asn D1159N mutation mutation certain certain sequence position certain certain certain sequence position certain D N This feature has been corrected as a result of our quality control procedures. The original label was 'D1159N'. Wed May 02 20:02:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp1159asn' Tue Jun 30 18:54:45 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp1159Asn' spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm phosphorylation phosphorylation reaction phosphorylation insr-irs2-1 2 12 unspecified role unspecified role unspecified role unspecified role Region 620-634 Region 620-634 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 14 unspecified role unspecified role unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction irs2-igf1r-2 1 12 unspecified role unspecified role bait bait Region 591-733 Region 591-733 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P81122:p.Tyr628Phe Y628F mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'Y628F'. Wed May 02 16:24:07 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr628phe' Tue Jun 30 17:22:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr628Phe' His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 13 unspecified role unspecified role prey prey Region 956-1256 Region 956-1256 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction insr-irs2-2 11 12 unspecified role unspecified role unspecified role unspecified role Region 620-634 Region 620-634 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 14 unspecified role unspecified role unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction insr-irs2-3 9 12 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 591-733 Region 591-733 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 14 enzyme enzyme unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm phosphorylation phosphorylation reaction phosphorylation irs2-insr-6 8 12 unspecified role unspecified role bait bait Region 602-637 Region 602-637 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain P81122:p.Tyr621Ala Y621A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y621A'. Wed May 02 19:01:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr621ala' Tue Jun 30 19:34:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr621Ala' P81122:p.Tyr624Ala Y624A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y A This feature has been corrected as a result of our quality control procedures. The original label was 'Y624A'. Wed May 02 16:59:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr624ala' Tue Jun 30 18:59:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr624Ala' P81122:p.Asp627Ala D627A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain D A This feature has been corrected as a result of our quality control procedures. The original label was 'D627A'. Wed May 02 18:01:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp627ala' Tue Jun 30 16:25:41 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp627Ala' P81122:p.Tyr628Phe Y628F mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain Y F This feature has been corrected as a result of our quality control procedures. The original label was 'Y628F'. Wed May 02 16:24:09 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr628phe' Tue Jun 30 19:11:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr628Phe' P81122:p.Gly629Ala G629A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain G A This feature has been corrected as a result of our quality control procedures. The original label was 'G629A'. Wed May 02 19:49:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly629ala' Tue Jun 30 17:16:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly629Ala' P81122:p.Ile631Ala I631A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain I A This feature has been corrected as a result of our quality control procedures. The original label was 'I631A'. Wed May 02 16:49:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile631ala' Tue Jun 30 18:07:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile631Ala' P81122:p.Ile633Ala I633A mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain I A This feature has been corrected as a result of our quality control procedures. The original label was 'I633A'. Wed May 02 16:15:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile633ala' Tue Jun 30 19:31:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile633Ala' His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 14 unspecified role unspecified role prey prey Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction 1 nodeMerge04 2012-09-20 insr-irs2-4 6 12 unspecified role unspecified role unspecified role unspecified role Region 620-634 Region 620-634 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 14 unspecified role unspecified role unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction 1 nodeMerge04 2012-09-20 insr-irs2-5 10 12 unspecified role unspecified role unspecified role unspecified role Region 620-634 Region 620-634 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain in vitro In vitro 14 unspecified role unspecified role unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction 1 nodeMerge04 2012-09-20 insr-irs2-6 5 12 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 591-733 Region 591-733 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli 14 enzyme enzyme unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm phosphorylation phosphorylation reaction phosphorylation 1 nodeMerge04 2012-09-20 insr-insr-3 3 14 enzyme enzyme unspecified role unspecified role Region 956-1283 Region 956-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 14 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 978-1283 Region 978-1283 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain P06213-1:p.Asp1159Asn D1159N mutation mutation certain certain sequence position certain certain certain sequence position certain D N This feature has been corrected as a result of our quality control procedures. The original label was 'D1159N'. Wed May 02 15:33:20 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp1159asn' Tue Jun 30 15:59:48 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp1159Asn' spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm phosphorylation phosphorylation reaction phosphorylation 1 nodeMerge04 2012-09-20