DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 2008 imex curation Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. DIP original experiment: DIP-259523X Nature 2008 IMEx NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 2008 imex curation Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. DIP original experiment: DIP-259522X Nature 2008 IMEx NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 2008 imex curation Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. DIP original experiment: DIP-259524X Nature 2008 IMEx NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 2008 imex curation Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. DIP original experiment: DIP-259520X Nature 2008 IMEx NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 2008 imex curation Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Moore CB., Bergstralh DT., Duncan JA., Lei Y., Morrison TE., Zimmermann AG., Accavitti-Loper MA., Madden VJ., Sun L., Ye Z., Lich JD., Heise MT., Chen Z., Ting JP. DIP original experiment: DIP-259521X Nature 2008 IMEx NLRX1 is a regulator of mitochondrial antiviral immunity. q7z434-1 Mitochondrial antiviral-signaling protein MAVS IPS1 KIAA1271 VISA CARD adapter inducing interferon beta Interferon beta promoter stimulator protein 1 Putative NF-kappa-B-activating protein 031N Virus-induced-signaling adapter protein protein human Homo sapiens Human MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH DIP protein Q7Z434-1 original sequence version: 117 DIP protein Q7Z434 original sequence version: 109 DIP protein Q7Z434 original sequence version: 112 DIP protein Q7Z434 original sequence version: 52 DIP protein Q7Z434 original sequence version: 107 DIP protein Q7Z434-1 original sequence version: 107 DIP protein Q7Z434 original sequence version: 95 DIP protein Q7Z434 original sequence version: 69 DIP protein Q7Z434 original sequence version: 72 DIP protein Q7Z434-1 original sequence version: 72 DIP protein Q7Z434 original sequence version: 92 DIP protein Q7Z434 original sequence version: 129 DIP protein Q7Z434 original sequence version: 111 o95786-1 Antiviral innate immune response receptor RIG-I Probable ATP-dependent RNA helicase DDX58 DDX58 DEAD box protein 58 RIG-I-like receptor 1 Retinoic acid-inducible gene 1 protein Retinoic acid-inducible gene I protein protein protein human Homo sapiens Human MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAEMSK DIP protein O95786-1 original sequence version: 126 DIP protein O95786-1 original sequence version: 118 DIP protein O95786 original sequence version: 63 DIP protein O95786 original sequence version: 116 DIP protein O95786-1 original sequence version: 116 DIP protein O95786 original sequence version: 105 DIP protein O95786 original sequence version: 80 DIP protein O95786-1 original sequence version: 78 DIP protein O95786 original sequence version: 102 DIP protein O95786-1 original sequence version: 131 DIP protein O95786 original sequence version: 134 DIP protein O95786 original sequence version: 135 DIP protein O95786-1 original sequence version: 120 DIP protein O95786 original sequence version: 120 q86ut6-1 NLR family member X1 NLRX1 NOD26 NOD5 NOD9 Caterpiller protein 11.3 Nucleotide-binding oligomerization domain protein 26 Nucleotide-binding oligomerization domain protein 5 Nucleotide-binding oligomerization domain protein 9 protein protein human Homo sapiens Human MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGSSGS DIP protein Q86UT6-1 original sequence version: 98 nlrx1_human NLR family member X1 NLRX1 NOD26 NOD5 NOD9 Caterpiller protein 11.3 Nucleotide-binding oligomerization domain protein 26 Nucleotide-binding oligomerization domain protein 5 Nucleotide-binding oligomerization domain protein 9 protein protein human Homo sapiens Human MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGSSGS DIP protein Q86UT6 original sequence version: 98 mavs-nlrx1-1 4 6 unspecified role unspecified role bait bait human Homo sapiens Human 9 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association mavs-nlrx1-2 2 6 unspecified role unspecified role bait bait human Homo sapiens Human 8 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human physical association physical association mavs-ddx58-4 1 7 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 6 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association nlrx1-mavs-1 5 6 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 8 unspecified role unspecified role bait bait Region 1-556 Region 1-556 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human physical association physical association nlrx1-mavs-2 3 6 unspecified role unspecified role prey prey Region 10-77 Region 10-77 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 8 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human physical association physical association