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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
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      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Structural basis for ligand-mediated mouse GITR activation.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="18178614" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0711206105" refType="primary-reference" refTypeAc="MI:0358"/>
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            <secondaryRef db="imex" dbAc="MI:0670" id="IM-9047" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Structural basis for ligand-mediated mouse GITR activation.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Zhou Z.,  Tone Y.,  Song X.,  Furuuchi K.,  Lear JD.,  Waldmann H.,  Tone M.,  Greene MI.,  Murali R.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-9047" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-68205X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="2Q8O" refType="identity" refTypeAc="MI:0356"/>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="562">
            <names>
              <shortLabel>ecolx</shortLabel>
              <fullName>Escherichia coli</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Zhou Z., Tone Y., Song X., Furuuchi K., Lear JD., Waldmann H., Tone M., Greene MI., Murali R.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-68205X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Structural basis for ligand-mediated mouse GITR activation.</attribute>
        </attributeList>
      </experimentDescription>
      <experimentDescription id="2">
        <names>
          <fullName>Structural basis for ligand-mediated mouse GITR activation.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="18178614" refType="primary-reference" refTypeAc="MI:0358"/>
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            <secondaryRef db="imex" dbAc="MI:0670" id="IM-9047" refType="imex-primary" refTypeAc="MI:0662"/>
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          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Structural basis for ligand-mediated mouse GITR activation.</attribute>
            <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
            <attribute name="publication year" nameAc="MI:0886">2008</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Zhou Z.,  Tone Y.,  Song X.,  Furuuchi K.,  Lear JD.,  Waldmann H.,  Tone M.,  Greene MI.,  Murali R.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
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        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-9047" refType="imex-primary" refTypeAc="MI:0662"/>
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          <secondaryRef db="doi" dbAc="MI:0574" id="10.1073/pnas.0711206105" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="562">
            <names>
              <shortLabel>ecolx</shortLabel>
              <fullName>Escherichia coli</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>solution sedimentati</shortLabel>
            <fullName>cosedimentation in solution</fullName>
            <alias type="synonym" typeAc="MI:1041">solution sedimentati</alias>
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          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0028" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="pubmed" dbAc="MI:0446" id="10410796" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
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          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Zhou Z., Tone Y., Song X., Furuuchi K., Lear JD., Waldmann H., Tone M., Greene MI., Murali R.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-68206X</attribute>
          <attribute name="journal" nameAc="MI:0885">Proceedings of the National Academy of Sciences of the United States of America</attribute>
          <attribute name="publication year" nameAc="MI:0886">2008</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Structural basis for ligand-mediated mouse GITR activation.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>tnf18_mouse</shortLabel>
          <fullName>Tumor necrosis factor ligand superfamily member 18</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Gitrl</alias>
          <alias type="gene name" typeAc="MI:0301">Tnfsf18</alias>
          <alias type="gene name synonym" typeAc="MI:0302">GITR ligand</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Glucocorticoid-induced TNF-related ligand</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q7TS55" version="TrEMBL_22" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000083251" version="SP_116" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q7TNY2" version="SP_58" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q80YG2" version="SP_58" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-523345" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000066755" version="SP_116" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000086084" version="SP_116" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002250" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002309" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0002687" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005125" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005164" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010759" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032813" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0033209" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042129" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042531" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043254" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045785" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0050729" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0090026" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000329" version="SP_116"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000508" version="SP_116"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006052" version="SP_116"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008983" version="SP_116"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR042380" version="SP_116"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2Q8O" version="SP_116"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QDN" version="SP_116"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3B9I" version="SP_116"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3FC0" version="SP_116"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7KHX" version="SP_116"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5669034" version="SP_116"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_899247.3"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29663N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="10090">
          <names>
            <shortLabel>mouse</shortLabel>
            <fullName>Mus musculus</fullName>
            <alias type="synonym" typeAc="MI:1041">Mouse</alias>
          </names>
        </organism>
        <sequence>MEEMPLRESSPQRAERCKKSWLLCIVALLLMLLCSLGTLIYTSLKPTAIESCMVKFELSSSKWHMTSPKPHCVNTTSDGKLKILQSGTYLIYGQVIPVDKKYIKDNAPFVVQIYKKNDVLQTLMNDFQILPIGGVYELHAGDNIYLKFNSKDHIQKTNTYWGIILMPDLPFIS</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q7TS55 original sequence version: 24</attribute>
          <attribute name="crc64">0F08494CACF424D2</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-9047-1">
        <names>
          <shortLabel>tnfsf18-4</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-59150E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15678933" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="imex" dbAc="MI:0670" id="IM-9047-1" refType="imex-primary" refTypeAc="MI:0662"/>
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        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
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                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
            <experimentalRoleList>
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                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
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          </xref>
        </interactionType>
      </interaction>
      <interaction id="6" imexId="IM-9047-2">
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          <shortLabel>tnfsf18-5</shortLabel>
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          <primaryRef db="dip" dbAc="MI:0465" id="DIP-59150E" refType="identity" refTypeAc="MI:0356"/>
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        <experimentList>
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        </experimentList>
        <participantList>
          <participant id="7">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            </biologicalRole>
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                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
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                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
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      </interaction>
    </interactionList>
  </entry>
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