DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. DIP original experiment: DIP-111394X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. DIP original experiment: DIP-111390X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. DIP original experiment: DIP-111389X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. DIP original experiment: DIP-111391X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. DIP original experiment: DIP-111388X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. DIP original experiment: DIP-111393X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Irelan JT., Murphy TJ., DeJesus PD., Teo H., Xu D., Gomez-Ferreria MA., Zhou Y., Miraglia LJ., Rines DR., Verma IM., Sharp DJ., Tergaonkar V., Chanda SK. DIP original experiment: DIP-111392X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx A role for IkappaB kinase 2 in bipolar spindle assembly. ikka_human Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK IKKA TCF16 I-kappa-B kinase 1 Conserved helix-loop-helix ubiquitous kinase Nuclear factor NF-kappa-B inhibitor kinase alpha Transcription factor 16 protein protein human Homo sapiens Human MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE DIP protein O15111 original sequence version: 91 DIP protein O15111 original sequence version: 123 DIP protein O15111 original sequence version: 133 DIP protein O15111 original sequence version: 118 DIP protein O15111 original sequence version: 125 DIP protein O15111 original sequence version: 96 4EA55C6FFC66FA16 tpx2_human Targeting protein for Xklp2 TPX2 C20orf1 C20orf2 DIL2 HCA519 Restricted expression proliferation-associated protein 100 Differentially expressed in cancerous and non-cancerous lung cells 2 Protein fls353 Hepatocellular carcinoma-associated antigen 519 Hepatocellular carcinoma-associated antigen 90 protein protein human Homo sapiens Human MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC DIP protein Q9ULW0 original sequence version: 104 DIP protein Q9ULW0 original sequence version: 112 This sequence has been withdrawn from Uniprot. E028E0BB50BBCA0F nemo_human NF-kappa-B essential modulator IKBKG FIP3 NEMO NF-kappa-B essential modifier Inhibitor of nuclear factor kappa-B kinase subunit gamma IkB kinase-associated protein 1 FIP-3 protein protein human Homo sapiens Human MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE DIP protein Q9Y6K9 original sequence version: 85 DIP protein Q9Y6K9 original sequence version: 118 DIP protein Q9Y6K9 original sequence version: 123 DIP protein Q9Y6K9 original sequence version: 141 DIP protein Q9Y6K9 original sequence version: 125 DIP protein Q9Y6K9 original sequence version: 156 DIP protein Q9Y6K9 original sequence version: 83 DIP protein Q9Y6K9 original sequence version: 132 DIP protein Q9Y6K9 original sequence version: 124 DIP protein Q9Y6K9 original sequence version: 90 322D1037881447FF fbw1a_human F-box/WD repeat-containing protein 1A BTRC BTRCP FBW1A FBXW1A F-box and WD repeats protein beta-TrCP E3RSIkappaB pIkappaBalpha-E3 receptor subunit Epididymis tissue protein Li 2a protein protein human Homo sapiens Human MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR DIP protein Q9Y297 original sequence version: 142 DIP protein Q9Y297 original sequence version: 153 DIP protein Q9Y297 original sequence version: 144 DIP protein Q9Y297 original sequence version: 145 DIP protein Q9Y297 original sequence version: 106 DIP protein Q9Y297 original sequence version: 82 DIP protein Q9Y297 original sequence version: 111 DIP protein Q9Y297 original sequence version: 125 4C67F3B7E400FD37 ikkb_human Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB IKKB I-kappa-B kinase 2 Nuclear factor NF-kappa-B inhibitor kinase beta Serine/threonine protein kinase IKBKB protein protein human Homo sapiens Human MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS DIP protein O14920 original sequence version: 89 DIP protein O14920 original sequence version: 100 DIP protein O14920 original sequence version: 121 DIP protein O14920 original sequence version: 126 DIP protein O14920 original sequence version: 136 DIP protein O14920 original sequence version: 128 DIP protein O14920-1 original sequence version: 151 DIP protein O14920 original sequence version: 142 DIP protein O14920 original sequence version: 159 DIP protein O14920 original sequence version: 93 DIP protein O14920 original sequence version: 124 DIP protein O14920-1 original sequence version: 178 DIP protein O14920 original sequence version: 85 F9CADF671AE9E14E aurka_human Aurora kinase A AIRK1 Serine/threonine-protein kinase 15 Aurora/IPL1-related kinase 1 Breast tumor-amplified kinase STK6 AIK ARK1 AURA BTAK STK15 AURKA AYK1 IAK1 Aurora 2 Serine/threonine-protein kinase 6 Serine/threonine-protein kinase aurora-A protein protein human Homo sapiens Human MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS DIP protein O14965 original sequence version: 181 DIP protein O14965 original sequence version: 146 DIP protein O14965 original sequence version: 124 DIP protein O14965 original sequence version: 160 DIP protein O14965 original sequence version: 138 DIP protein O14965 original sequence version: 98 125F3594834CD157 chuk-aurka-1 5 8 unspecified role unspecified role bait bait human Homo sapiens Human 13 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association ikbkb-aurka-1 4 12 unspecified role unspecified role bait bait human Homo sapiens Human 13 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association aurka-ikbkb-1 1 12 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli 13 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction chuk-tpx2-1 3 8 unspecified role unspecified role bait bait human Homo sapiens Human 9 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association ikbkg-aurka-1 7 10 unspecified role unspecified role bait bait human Homo sapiens Human 13 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association aurka-btrc-1 2 11 unspecified role unspecified role prey prey human Homo sapiens Human 13 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association ikbkb-tpx2-1 6 12 unspecified role unspecified role bait bait human Homo sapiens Human 9 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association