DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Sjöström M., Stenström K., Eneling K., Zwiller J., Katz AI., Takemori H., Bertorello AM. Only protein-protein interactions in vitro In vitro protein kinase assay protein kinase assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Sjöström M., Stenström K., Eneling K., Zwiller J., Katz AI., Takemori H., Bertorello AM. DIP original experiment: DIP-111387X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Sjöström M., Stenström K., Eneling K., Zwiller J., Katz AI., Takemori H., Bertorello AM. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Sjöström M., Stenström K., Eneling K., Zwiller J., Katz AI., Takemori H., Bertorello AM. DIP original experiment: DIP-111386X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. sik1_rat Serine/threonine-protein kinase SIK1 Sik1 Kid2 Sik Snf1lk Protein kinase KID2 Salt-inducible kinase 1 Serine/threonine-protein kinase SNF1-like kinase 1 protein protein rat Rattus norvegicus (Rat) Rat MVIMSEFSAVPTGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADPTLLQQDDPAFSMQGYTSNLGDYNEQVLGIMQALGIDRQRTVESLQNSSYNHFAAIYYLLLERLREHRSTQPSSRATPAPARQPQLRNSDLSSLEVPQEILPCDPFRPSLLCPQPQALAQSVLQAEIDCDLHSSLQPLFFPLDTNCSGVFRHRSISPSSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPPCIIVSSSAAVSPSEGTSSDSCLPFSASEGPAGLGGGLATPGLLGTSSPVRLASPFLGSQSATPVLQSQAGLGATVLPPVSFQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVCQSSIRGSRGGMSTFHTPAPSSGLQGCTASSREGRSLLEEVLHQQRLLQLQHHSAVSSDYQQAPQLSPVPYVLTPCDGLLVSGIPLLPTPLLQPGMSPVASAAQLLDAHLHISAGPVALPTGPLPQCLTRLSPSCDPAGLPQGDCEMEDLTSGQRGTFVLVQ DIP protein Q9R1U5 original sequence version: 68 ppme1_mouse Protein phosphatase methylesterase 1 Ppme1 Pme1 protein protein mouse Mus musculus Mouse MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVKNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGAIAVHTAAANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC DIP protein Q8BVQ5 original sequence version: 53 mint Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) 2BD07B588299DB6D at1a1_human Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1 Sodium pump subunit alpha-1 protein protein human Homo sapiens Human MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY DIP protein P05023 original sequence version: 111 F3C6FDE04FB3F667 atp1a1-ppme1-1 2 4 unspecified role unspecified role prey prey human Homo sapiens Human 5 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association ppme1-sik1-1 1 4 enzyme target enzyme target substrate substrate unspecified role unspecified role human Homo sapiens Human 3 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction