DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Huang YJ., Huang Y., Baldassarre H., Wang B., Lazaris A., Leduc M., Bilodeau AS., Bellemare A., Côté M., Herskovits P., Touati M., Turcotte C., Valeanu L., Lemée N., Wilgus H., Bégin I., Bhatia B., Rao K., Neveu N., Brochu E., Pierson J., Hockley DK., Cerasoli DM., Lenz DE., Karatzas CN., Langermann S. Only protein-protein interactions goat Capra hircus Goat molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Huang YJ., Huang Y., Baldassarre H., Wang B., Lazaris A., Leduc M., Bilodeau AS., Bellemare A., Côté M., Herskovits P., Touati M., Turcotte C., Valeanu L., Lemée N., Wilgus H., Bégin I., Bhatia B., Rao K., Neveu N., Brochu E., Pierson J., Hockley DK., Cerasoli DM., Lenz DE., Karatzas CN., Langermann S. DIP original experiment: DIP-113933X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proceedings of the National Academy of Sciences of the United States of America 2007 imex curation Huang YJ., Huang Y., Baldassarre H., Wang B., Lazaris A., Leduc M., Bilodeau AS., Bellemare A., Côté M., Herskovits P., Touati M., Turcotte C., Valeanu L., Lemée N., Wilgus H., Bégin I., Bhatia B., Rao K., Neveu N., Brochu E., Pierson J., Hockley DK., Cerasoli DM., Lenz DE., Karatzas CN., Langermann S. Only protein-protein interactions goat Capra hircus Goat comig non denat gel comigration in non denaturing gel electrophoresis comig non denat gel predetermined predetermined participant predetermined Huang YJ., Huang Y., Baldassarre H., Wang B., Lazaris A., Leduc M., Bilodeau AS., Bellemare A., Côté M., Herskovits P., Touati M., Turcotte C., Valeanu L., Lemée N., Wilgus H., Bégin I., Bhatia B., Rao K., Neveu N., Brochu E., Pierson J., Hockley DK., Cerasoli DM., Lenz DE., Karatzas CN., Langermann S. DIP original experiment: DIP-113932X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. chle_human Cholinesterase BCHE CHE1 Acylcholine acylhydrolase Choline esterase II Butyrylcholine esterase Pseudocholinesterase protein protein human Homo sapiens Human MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL DIP protein P06276 original sequence version: 99 DIP protein P06276 original sequence version: 129 Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait mint C9836409D9057F27 bche-2 2 3 unspecified role unspecified role unspecified role unspecified role goat Capra hircus Goat direct interaction direct interaction bche-3 1 3 unspecified role unspecified role unspecified role unspecified role goat Capra hircus Goat direct interaction direct interaction