<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="17632546" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/nature06009" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15647587" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-21174" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.</attribute>
            <attribute name="journal" nameAc="MI:0885">Nature</attribute>
            <attribute name="publication year" nameAc="MI:0886">2007</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Martinez Molina D.,  Wetterholm A.,  Kohl A.,  McCarthy AA.,  Niegowski D.,  Ohlson E.,  Hammarberg T.,  Eshaghi S.,  Haeggström JZ.,  Nordlund P.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-21174" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="2UUH" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-253174X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="2UUI" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="17632546" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/nature06009" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="4922">
            <names>
              <shortLabel>picpa</shortLabel>
              <fullName>Pichia pastoris (Yeast)</fullName>
              <alias type="synonym" typeAc="MI:1041">Yeast</alias>
              <alias type="synonym" typeAc="MI:1041">Pichia pastoris</alias>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>x-ray diffraction</shortLabel>
            <fullName>x-ray crystallography</fullName>
            <alias type="go synonym" typeAc="MI:0303">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">X-ray</alias>
            <alias type="synonym" typeAc="MI:1041">x-ray diffraction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Martinez Molina D., Wetterholm A., Kohl A., McCarthy AA., Niegowski D., Ohlson E., Hammarberg T., Eshaghi S., Haeggström JZ., Nordlund P.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-253174X</attribute>
          <attribute name="journal" nameAc="MI:0885">Nature</attribute>
          <attribute name="publication year" nameAc="MI:0886">2007</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>ltc4s_human</shortLabel>
          <fullName>Leukotriene C4 synthase</fullName>
          <alias type="gene name" typeAc="MI:0301">LTC4S</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Leukotriene-C(4) synthase</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Glutathione S-transferase LTC4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Leukotriene-C4 synthase</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q16873" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000292596" version="SP_186" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000492334" version="SP_186" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8N6P0" version="SP_150" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UC73" version="SP_150" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UD18" version="SP_150" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-12241118" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000213316" version="SP_186" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000283887" version="SP_186" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000292596" version="SP_186" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000639087" version="SP_186" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004364" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004464" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004602" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005635" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005640" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005783" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005789" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006691" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008047" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008289" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019370" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031965" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042759" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_186"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001129" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001446" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018295" version="SP_186"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023352" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2PNO" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2UUH" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2UUI" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3B29" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HKK" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3LEO" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3PCV" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4J7T" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4J7Y" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JC7" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JCZ" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JRZ" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4WAB" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HV9" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6R7D" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2142688" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2142691" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2142700" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9026762" version="SP_186"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9026766" version="SP_186"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BPM" version="SP_186"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_665874.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-48473N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein Q16873 original sequence version: 91</attribute>
          <attribute name="remark-internal">DIP protein Q16873 original sequence version: 120</attribute>
          <attribute name="crc64">04E269B475063037</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-21174-1">
        <names>
          <shortLabel>ltc4s-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-102970E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15647608" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-21174-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="4922">
                <names>
                  <shortLabel>picpa</shortLabel>
                  <fullName>Pichia pastoris (Yeast)</fullName>
                  <alias type="synonym" typeAc="MI:1041">Yeast</alias>
                  <alias type="synonym" typeAc="MI:1041">Pichia pastoris</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>